Chia-Wen Tsai
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View article: Impact of Interleukin-12B Genotypes on Breast Cancer Risk
Impact of Interleukin-12B Genotypes on Breast Cancer Risk Open
IL-12B rs3212227 is not a major genetic determinant of overall BC susceptibility in this population but may exert age-dependent protective effects. Further studies integrating IL-12 expression profiling and additional IL-12 pathway …
View article: Contribution of <i>Xeroderma Pigmentosum</i> Complementation Group C Genotypes to Colorectal Cancer in Taiwanese
Contribution of <i>Xeroderma Pigmentosum</i> Complementation Group C Genotypes to Colorectal Cancer in Taiwanese Open
Although the investigated XPC polymorphisms were not associated with CRC susceptibility, the rs2228000 and rs2228001 variant genotypes may serve as novel prognostic biomarkers. Further large-scale studies across diverse populations …
View article: Insights from Tissue Inhibitor of Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Childhood Acute Lymphocytic Leukemia Risk
Insights from Tissue Inhibitor of Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Childhood Acute Lymphocytic Leukemia Risk Open
TIMP-2 rs8179090, particularly the CC genotype, may serve as a novel biomarker for childhood ALL susceptibility and prognosis, especially in younger and male patients. Genotyping of this polymorphism could support early risk assessm…
View article: Significant Contributions of Interleukin-13 Genotypes to Asthma Severity
Significant Contributions of Interleukin-13 Genotypes to Asthma Severity Open
While IL-13 rs1800925 and rs20541 polymorphisms were not significantly associated with overall asthma susceptibility, the rs1800925 TT genotype may confer increased risk in younger adults and is significantly linked to more severe a…
View article: Associations of Matrix Metalloproteinase-7 Promoter Genotypes With Asthma Risk in Taiwan
Associations of Matrix Metalloproteinase-7 Promoter Genotypes With Asthma Risk in Taiwan Open
MMP-7-181A>G is not a major susceptibility marker for asthma. However, the G allele may serve as a potential biomarker for younger-onset and more severe asthma phenotypes in Taiwanese individuals.
View article: Association of MMP-11 Genotypes With Colorectal Cancer in Taiwan
Association of MMP-11 Genotypes With Colorectal Cancer in Taiwan Open
Although the investigated MMP-11 polymorphisms were not associated with CRC susceptibility, the rs738791 and rs2267029 variant genotypes may serve as potential prognostic biomarkers.
View article: Impact of Vitamin D Receptor Genotypes on Taiwan Asthma Risk
Impact of Vitamin D Receptor Genotypes on Taiwan Asthma Risk Open
The variant A allele at VDR rs2228570 was associated with higher asthma susceptibility, and may serve as a predictor for asthma symptom severity. Our findings encouraged further validation in larger and diverse populations to furthe…
View article: Association of Interleukin-12A Genotypes With Nasopharyngeal Carcinoma Risk
Association of Interleukin-12A Genotypes With Nasopharyngeal Carcinoma Risk Open
IL-12A rs568408 may interact with tobacco and betel quid exposures to influence NPC susceptibility. These findings highlight the importance of integrating genetic and environmental factors in NPC risk assessment and warrant further …
View article: Association of Matrix Metalloproteinase-7 Genotypes With Nasopharyngeal Carcinoma Risk
Association of Matrix Metalloproteinase-7 Genotypes With Nasopharyngeal Carcinoma Risk Open
While MMP-7 rs11568818 does not directly influence NPC susceptibility in a Taiwanese population, its interaction with smoking may contribute to elevated NPC risk.
View article: Significant Association of Matrix Metalloproteinase-9 Polymorphisms With Triple Negative Breast Cancer Risk
Significant Association of Matrix Metalloproteinase-9 Polymorphisms With Triple Negative Breast Cancer Risk Open
The MMP-9 rs3918242 TT genotype may serve as a potential predictive biomarker for TNBC in the Taiwanese population.
View article: Impacts of Methylenetetrahydrofolate Reductase Genotypes on Hallux Valgus
Impacts of Methylenetetrahydrofolate Reductase Genotypes on Hallux Valgus Open
The TT genotype of MTHFR rs1801133 is associated with an increased risk of HV. Subgrouping HV patients based on their MTHFR genotypes and related comorbidities, such as rheumatoid arthritis, may offer a new approach to diagnosis.
View article: Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk
Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk Open
View article: The contributions of the tissue inhibitor of metalloproteinase-1 genotypes to triple negative breast cancer risk
The contributions of the tissue inhibitor of metalloproteinase-1 genotypes to triple negative breast cancer risk Open
View article: Diagnostic Impacts of Aldehyde Dehydrogenase 2 Genetic Variants on Hepatocellular Carcinoma Susceptibility
Diagnostic Impacts of Aldehyde Dehydrogenase 2 Genetic Variants on Hepatocellular Carcinoma Susceptibility Open
Background/Aim: The role of alcohol consumption and aldehyde dehydrogenase 2 (ALDH2) genotype in hepatocellular carcinoma (HCC) development remains uncertain. Materials and Methods: We conducted genotyping of the ALDH2 rs671 single nucleot…
View article: Impact of Matrix Metalloproteinase-8 Polymorphisms on Nasopharyngeal Carcinoma Risk
Impact of Matrix Metalloproteinase-8 Polymorphisms on Nasopharyngeal Carcinoma Risk Open
Upregulation of matrix metallo-proteinase-8 (MMP-8) serves as a protein-based indicator for predicting nasopharyngeal carcinoma (NPC) metastasis. Nevertheless, the role of MMP-8 genotypes in NPC has never been investigated. This study aime…
View article: The Significant Associations between Epigenetic Clocks and Bladder Cancer Risks
The Significant Associations between Epigenetic Clocks and Bladder Cancer Risks Open
Bladder cancer is an age-related disease, with over three-quarters of cases occurring in individuals aged 65 years and older. Accelerated biological aging has been linked to elevated cancer risks. Epigenetic clocks serve as excellent predi…
View article: Contribution of Matrix Metalloproteinase-7 Genotypes to Endometriosis Risk in Taiwan
Contribution of Matrix Metalloproteinase-7 Genotypes to Endometriosis Risk in Taiwan Open
MMP7 rs11568818 GG genotype was found to be a novel marker for endometriosis risk in Taiwanese.
View article: The Significant Impacts of Interleukin-8 Genotypes on the Risk of Colorectal Cancer in Taiwan
The Significant Impacts of Interleukin-8 Genotypes on the Risk of Colorectal Cancer in Taiwan Open
Interleukin-8 (IL-8), a pro-inflammatory cytokine, is upregulated in CRC and plays an important role in its development and progression. Genetic variants in the IL-8 gene may impact the risk of CRC by modulating IL-8 levels. Our primary ob…
View article: Non-Homologous End-Joining Pathway Genotypes Significantly Associated with Nasopharyngeal Carcinoma Susceptibility
Non-Homologous End-Joining Pathway Genotypes Significantly Associated with Nasopharyngeal Carcinoma Susceptibility Open
Defects in the non-homologous end-joining (NHEJ) DNA repair pathway lead to genomic instability and carcinogenesis. However, the roles of individual NHEJ genes in nasopharyngeal carcinoma (NPC) etiology are not well-understood. The aim of …
View article: Interaction of a Novel Alternatively Spliced Variant of HSD11B1L with Parkin Enhances the Carcinogenesis Potential of Glioblastoma: Peiminine Interferes with This Interaction
Interaction of a Novel Alternatively Spliced Variant of HSD11B1L with Parkin Enhances the Carcinogenesis Potential of Glioblastoma: Peiminine Interferes with This Interaction Open
Glioblastoma (GBM) is a primary brain tumor of unknown etiology. It is extremely aggressive, incurable and has a short average survival time for patients. Therefore, understanding the precise molecular mechanisms of this diseases is essent…
View article: Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk
Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk Open
rs11568818 and rs11568819 at MMP-2 promoter region played minor roles in determining individual PCa risk.
View article: C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect
C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect Open
Amyotrophic lateral sclerosis (ALS) is a fatal disease in which motor neurons gradually degenerate. The mutation of the C9orf72 gene is the main genetic cause of ALS (C9-ALS). One of its specific pathological features is the production of …
View article: A Novel Splice Variant of BCAS1 Inhibits β-Arrestin 2 to Promote the Proliferation and Migration of Glioblastoma Cells, and This Effect Was Blocked by Maackiain
A Novel Splice Variant of BCAS1 Inhibits β-Arrestin 2 to Promote the Proliferation and Migration of Glioblastoma Cells, and This Effect Was Blocked by Maackiain Open
Brain-enriched myelin-associated protein 1 (BCAS1) is frequently highly expressed in human cancer, but its detailed function is unclear. Here, we identified a novel splice variant of the BCAS1 gene in glioblastoma multiforme (GBM) named BC…
View article: Significant miR-145-a genotypes to serve as asthma predictors
Significant miR-145-a genotypes to serve as asthma predictors Open
Background: Asthma is a chronic airway inflammation disease and the diagnosis and treatment strategies remain difficult. The study and application of miRNAs have rapidly become one of the hot spots of translational medical sciences. There …
View article: Contribution of<i>5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase</i>Genotypes to Colorectal Cancer in Taiwan
Contribution of<i>5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase</i>Genotypes to Colorectal Cancer in Taiwan Open
MTRR rs1801394 GG genotype can be a protective marker for CRC risk in Taiwan.
View article: Protective Effects of Gamma-mangostin on Hydrogen Peroxideinduced Cytotoxicity in Human Retinal Pigment Epithelial Cells
Protective Effects of Gamma-mangostin on Hydrogen Peroxideinduced Cytotoxicity in Human Retinal Pigment Epithelial Cells Open
Gamma-mangostin may conduct its eye-protective effects against H2O2-induced oxidative damage via anti- apoptotic and antioxidant mechanisms in ARPE-19 cells.
View article: Contribution of Interleukin-12A Genotypes to Breast Cancer Risk
Contribution of Interleukin-12A Genotypes to Breast Cancer Risk Open
IL-12A rs568408 and rs2243115 genotypes may not serve as good predictors of breast cancer risk.
View article: Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells
Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells Open
The present study investigated the impact of carnosic acid (CA) from rosemary on the levodopa ( L -dopa)-induced dyskinesia (LID) in rats treated with 6-hydroxydopamine (6-OHDA). To establish the model of LID, 6-OHDA-lesioned rats were inj…
View article: The Association of <i>MMP9</i> Promoter Rs3918242 Genotype With Gastric Cancer
The Association of <i>MMP9</i> Promoter Rs3918242 Genotype With Gastric Cancer Open
Carrying a T allele for MMP9 rs3918242 may be predictive for higher gastric cancer risk, and as a predictor for higher risk of metastasis.
View article: Contribution of<i>Matrix Metalloproteinase-1</i>Genotypes to Colorectal Cancer in Taiwan
Contribution of<i>Matrix Metalloproteinase-1</i>Genotypes to Colorectal Cancer in Taiwan Open
The genotypes at MMP-1 rs1799705 play a role in determining susceptibility to CRC risk in Taiwan.