Chidambra Dhariwal Halari
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View article: Rosiglitazone-Mediated Activation of PPARγ Restores HO1 Expression in the Human Preeclamptic Placenta
Rosiglitazone-Mediated Activation of PPARγ Restores HO1 Expression in the Human Preeclamptic Placenta Open
BACKGROUND: Preeclampsia is a hypertensive disorder of pregnancy characterized by chronic placental ischemia and suppression of proangiogenic proteins, causing oxidative stress, hypertension, and maternal systemic organ damage. The transcr…
View article: Decorin–induced, preeclampsia-associated microRNA-512-3p restrains extravillous trophoblast functions by targeting USF2/PPP3R1 axis
Decorin–induced, preeclampsia-associated microRNA-512-3p restrains extravillous trophoblast functions by targeting USF2/PPP3R1 axis Open
Decorin (DCN) is a leucine-rich proteoglycan produced by chorionic villus mesenchymal cells anddecidual cells during human pregnancy. Studies from our laboratory demonstrated that decidua-derived DCN restrains multiple trophoblast function…
View article: Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases Open
Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In t…
View article: Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells
Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells Open
Insulin-like growth factor-1 (IGF-1) bioavailability in pregnancy is governed by IGF binding protein (IGFBP-1) and its phosphorylation, which enhances the affinity of IGFBP-1 for the growth factor. The decidua is the predominant source of …
View article: Decorin production by the human decidua: role in decidual cell maturation
Decorin production by the human decidua: role in decidual cell maturation Open
Decidualization involves the proliferation and differentiation of fibroblast-like endometrial stromal cells into epithelioid-shaped and secretory ‘decidual’ cells in response to steroid hormones. Human decidual cells produce insulin-like g…
View article: Oncoyeasti: a web-based application to translate data obtained from Saccharomyces cerevisiae high-throughput drug screens into cancer therapeutics
Oncoyeasti: a web-based application to translate data obtained from Saccharomyces cerevisiae high-throughput drug screens into cancer therapeutics Open
The budding yeast ( Saccharomyces cerevisiae ) gene deletion library consists of a collection of more than 6,000 gene-deletion mutants and is useful for high-throughput screening of anti-cancer drugs. Because of the shorter doubling time a…
View article: Association between Alcohol Consumption and Smoking to Predisposing Conditions: Health Fair Study in Dominica
Association between Alcohol Consumption and Smoking to Predisposing Conditions: Health Fair Study in Dominica Open
Alcohol consumption and cigarette smoking seems to be an accepted social practice in every community. Their consequence poses a rising concern on the health and functionality of young individuals. Besides being identified as potential risk…
View article: A Study of Blood Pressure and Blood Glucose among Participants Attending a Health Fair in Dominica
A Study of Blood Pressure and Blood Glucose among Participants Attending a Health Fair in Dominica Open
With an estimate of over 1 billion hypertensive individuals and approximately 366 million diabetic individuals, blood pressure and blood glucose tests have belonged to the group of one of the most examined parameters. Studies have also sho…
View article: Prevalence of Overweight and Obese Individuals Attending a Health Fair in Dominica
Prevalence of Overweight and Obese Individuals Attending a Health Fair in Dominica Open
Global research of overweight and obese individuals is excruciatingly high. Records show over 1 billion presently overweight while 400 million are obese. Among these figures 2.8 million die annually. This is because increase in body mass i…
View article: A Systematic Review of the Integration of Ultrasound into Medical School Curriculum
A Systematic Review of the Integration of Ultrasound into Medical School Curriculum Open
We identified different ways ultrasound was being taught in medical schools and the feedback of medical students concerning what was learnt. From the articles we reviewed, different teaching methods were identified and most institutions us…
View article: Congenital Absence of Uvula: Case Report
Congenital Absence of Uvula: Case Report Open
Traditional Uvulectomy has been an age-long practice throughout Africa and certain parts of the Middle East. It is performed as a treatment to prevent throat infections for centuries and is carried out usually during infancy and childhood.…
View article: Motivational Factors for Aspiring Doctors
Motivational Factors for Aspiring Doctors Open
Conclusion From the statistical analysis we were able to suggest “service to humanity” is the major reason why students endure the strenuous progression of medical school. Being compassionate becomes a primary incentive, making other moti…
View article: Prevalence of Hypertension and Diabetes Mellitus Among Individuals Attending a Health Fair in Dominica
Prevalence of Hypertension and Diabetes Mellitus Among Individuals Attending a Health Fair in Dominica Open
Hypertension and Diabetes mellitus stands out to be one of the major diseases recorded worldwide. This has led to various responses by several organisations aiming at reducing and managing the incidence of these illnesses. Despite active i…