Chidera Emeonye
YOU?
Author Swipe
View article: Necrotizing enterocolitis causes increased ileal goblet cell loss in<i>Wnt2b</i>KO mice
Necrotizing enterocolitis causes increased ileal goblet cell loss in<i>Wnt2b</i>KO mice Open
WNT2B is Wnt ligand which is able to support intestinal stem cells (ISC) in culture and support the intestinal epithelium in vivo. We have previously shown that WNT2B is critical for resistance to colitis, but not small intestinal injury, …
View article: WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans
WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans Open
Background and aims WNT2B is a canonical Wnt ligand previously thought to be fully redundant with other Wnts in the intestinal epithelium. However, humans with WNT2B deficiency have severe intestinal disease, highlighting a critical role f…