Chie Aoki‐Utsubo
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View article: In vitro Immunomodulatory and Hepatoprotective Activities of Selected Indonesian Medicinal Plants
In vitro Immunomodulatory and Hepatoprotective Activities of Selected Indonesian Medicinal Plants Open
Bioactive compounds from plant extracts play a crucial role in drug discovery. These compounds can affect various physiological functions, including immunomodulation and hepatoprotection. This study sought to investigate the potential of s…
View article: Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents
Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents Open
Background: Medicinal plants have been demonstrated to possess various pharmacological effects including anti-hepatitis C virus. Acacia mangium is one of the Acacia genus that contain various metabolites. The metaboilites play an important…
View article: Identification of an Oligostilbene, Vaticanol B, from <i>Dryobalanops aromatica</i> Leaves as an Antiviral Compound against the Hepatitis C Virus
Identification of an Oligostilbene, Vaticanol B, from <i>Dryobalanops aromatica</i> Leaves as an Antiviral Compound against the Hepatitis C Virus Open
Chronic hepatitis C virus (HCV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Although current medications using direct-acting antivirals (DAAs) are highly effective and well-tolerated for treating patients with chron…
View article: Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents
Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents Open
Background: Medicinal plants have been demonstrated to possess various pharmacological effects including anti-hepatitis C virus. Acacia mangium is one of the Acacia genus that contain with various metabolites. The metaboilites play an imp…
View article: Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents
Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents Open
Background: Medicinal plants are potential resources for isolating drug candidates. Various plants have been reported to possess pharmacological effects including anti-hepatitis C activities. The current study examined the anti-hepatitis …
View article: Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin
Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin Open
Background: Hepatitis c virus infection is a global health problem which chronically infected 71 million people in the world. This infection has a risk of becoming liver cirrhosis and hepatocellular carcinoma. Since the current HCV therapy…
View article: Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus
Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus Open
Background: Hepatitis B virus (HBV) infects more than 300 million people globally and is a common cause of liver cancer. Current therapy using reverse transcriptase inhibitors require long-term treatment and the potential risk of developme…
View article: Antiviral Activity of Cananga odorata Against Hepatitis B Virus.
Antiviral Activity of Cananga odorata Against Hepatitis B Virus. Open
Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Current therapeutic drugs for chronic hepatitis B using pegylated interferons and nucleos(t)ide analogs have limited efficacy. Therefore, t…
View article: In Vitro study of Garcinia celebica L. Stem Barks against Hepatitis C virus and Hepatocellular Carcinoma
In Vitro study of Garcinia celebica L. Stem Barks against Hepatitis C virus and Hepatocellular Carcinoma Open
In this study, we are focused on Garcinia celebica as anti-HCV activity against JFH1 strain genotype 2a. The extraction process employed the use of maceration method. Starting from n-hexane solvent and another residue. The extracts were th…
View article: Antiviral Activities of <i>Curcuma</i> Genus against Hepatitis C Virus
Antiviral Activities of <i>Curcuma</i> Genus against Hepatitis C Virus Open
Hepatitis C virus (HCV) infection is one of the major public health problems in the world. Even though the new agents are shown to increase the sustained virology response, however, there are still many people who cannot access the therapy…
View article: Time-of-addition and Temperature-shift Assays to Determine Particular Step(s) in the Viral Life Cycle that is Blocked by Antiviral Substance(s)
Time-of-addition and Temperature-shift Assays to Determine Particular Step(s) in the Viral Life Cycle that is Blocked by Antiviral Substance(s) Open
Viruses infect their host cells to produce progeny virus particles through the sequential steps of the viral life cycle, such as viral attachment, entry, penetration and post-entry events. This protocol describes time-of-addition and tempe…
View article: Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies
Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies Open
In a narrow definition, virucidal activity represents the activity by which to interact with and physically disrupt viral particles. In a broad definition, it includes the activity by which to functionally inhibit (neutralize) viral infect…
View article: Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane
Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane Open
Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae . Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the…
View article: Antiviral activity of the dichloromethane extracts from Artocarpus heterophyllus leaves against hepatitis C virus
Antiviral activity of the dichloromethane extracts from Artocarpus heterophyllus leaves against hepatitis C virus Open
Objective: To determine anti-viral activities of three Artocarpus species: Artocarpus altilis, Artocarpus camansi, and Artocarpus heterophyllus (A. heterophyllus) against Hepatitis C Virus (HCV). Methods: Antiviral activities of the crude …