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View article: Non-invasive assessment of activated renal macrophages by imaging of colony-stimulating factor 1 receptor in mouse model with ischemic acute kidney injury
Non-invasive assessment of activated renal macrophages by imaging of colony-stimulating factor 1 receptor in mouse model with ischemic acute kidney injury Open
Our findings provide the first evidence supporting the utility of 11C-CPPC-PET as a clinically-available tool for non-invasive detection of activated renal macrophages, predominantly of the M2 phenotype.
View article: Effects of Extended‐Release Methylphenidate on Dopamine and Norepinephrine Transporters in Adults With Attention‐Deficit/Hyperactivity Disorder: A Longitudinal Dual‐Tracer <scp>PET</scp> Study
Effects of Extended‐Release Methylphenidate on Dopamine and Norepinephrine Transporters in Adults With Attention‐Deficit/Hyperactivity Disorder: A Longitudinal Dual‐Tracer <span>PET</span> Study Open
Aim Attention‐deficit/hyperactivity disorder (ADHD) is associated with dysregulation of dopamine and norepinephrine neurotransmission. Extended‐release methylphenidate (MPH), a first‐line treatment for ADHD, modulates these systems. Howeve…
View article: Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain
Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain Open
Histone deacetylase 6 (HDAC6) is a crucial target for the development of pharmaceuticals used in the treatment of neurodegenerative disorders. Here, we identified 16a as a candidate of positron emission tomography (PET) tracer for HDAC6 im…
View article: Quantification of monoamine oxidase B expression with 11C-SL25.1188 for imaging reactive astrocytes in patients with Alzheimer’s disease
Quantification of monoamine oxidase B expression with 11C-SL25.1188 for imaging reactive astrocytes in patients with Alzheimer’s disease Open
MAO-B density in patients with MCI/AD can be accurately estimated by calculating DVRs using a simplified quantification method that does not require arterial blood sampling. The estimated MAO-B density shows an increase that peaks at the M…
View article: Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias
Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias Open
Epileptiform discharges and neuronal hyperexcitability are key pathophysiological features of Alzheimer’s disease and related tauopathies. We previously identified selective dynfuntion of parvalbumin-positive GABAergic interneurons (PV neu…
View article: 562. <i>IN VIVO</i> ASSESSMENTS OF TAU PATHOLOGIES IN PATIENTS WITH LATE-ONSET PSYCHOSIS: A PET STUDY
562. <i>IN VIVO</i> ASSESSMENTS OF TAU PATHOLOGIES IN PATIENTS WITH LATE-ONSET PSYCHOSIS: A PET STUDY Open
Background Late-onset psychosis (LOP) has distinct clinical features compared to younger-onset psychosis. While previous postmortem and epidemiological studies have suggested a link between the neural substrates of LOP and neurodegenerativ…
View article: <i>In Vivo</i> Topographic Associations Between Tau Pathology, Atrophy, and Symptom Domains in Progressive Supranuclear Palsy
<i>In Vivo</i> Topographic Associations Between Tau Pathology, Atrophy, and Symptom Domains in Progressive Supranuclear Palsy Open
Background and Objectives Progressive supranuclear palsy (PSP) is a four-repeat tauopathy characterized by subcortical atrophy and distinctive motor impairments. Although tau pathology is presumed to drive neuronal loss, the spatial relati…
View article: Prediction of tumour hypoxia status from the washout of positron emitters in beam-monitoring PET: carbon-ion irradiation to tumour rat models
Prediction of tumour hypoxia status from the washout of positron emitters in beam-monitoring PET: carbon-ion irradiation to tumour rat models Open
Background: The aim of this study was to identify a hypoxic area in tumour imaging without the use of radiopharmaceuticals. Since tumour hypoxia status is an important indicator to evaluate effects of the treatment, frequent monitoring of …
View article: Evaluation of in vivo and in vitro binding property of a novel candidate PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers
Evaluation of in vivo and in vitro binding property of a novel candidate PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers Open
Background Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging biomarker for neuroinflammation and tumor-associated macrophages. However, existing positron emission tomography (PET) tracers for CSF1R imaging often suffer fr…
View article: Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy
Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy Open
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterized by impaired movement and frontal cognitive dysfunctions. While motor symptoms have been linked with subcortical tau deposits, network mechanisms underlying …
View article: IN VIVO CLASSIFICATION OF TAU PATHOLOGIES BY POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH FRONTOTEMPORAL DEMENTIA
IN VIVO CLASSIFICATION OF TAU PATHOLOGIES BY POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH FRONTOTEMPORAL DEMENTIA Open
Background Frontotemporal dementia (FTD) is a group of neurodegenerative disorders with diverse clinical and neuropathological features. In vivo neuropathological assessments of FTD at an individual level have not hitherto been successful.…
View article: Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models
Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models Open
Non-invasive determination of amyloid-β peptide (Aβ) and tau deposition are important for early diagnosis and therapeutic intervention for Alzheimer's disease (AD) and non-AD tauopathies. In the present study, we investigated the capacity …
View article: Thoracoscopic closure of an H-type tracheoesophageal fistula: A case report
Thoracoscopic closure of an H-type tracheoesophageal fistula: A case report Open
Introduction: Isolated h-type tracheoesophageal fistula (H-TEF) without esophageal discontinuity is rare and poses challenges in selecting a surgical approach due to the height of the fistula within the thoracic cavity. Case presentation: …
View article: <i>In vivo</i> PET classification of tau pathologies in patients with frontotemporal dementia
<i>In vivo</i> PET classification of tau pathologies in patients with frontotemporal dementia Open
Frontotemporal dementia refers to a group of neurodegenerative disorders with diverse clinical and neuropathological features. In vivo neuropathological assessments of frontotemporal dementia at an individual level have hitherto not been s…
View article: The aftermath of boxing: Longitudinal changes of cerebral retention patterns of <sup>18</sup>F‐florzolotau (<sup>18</sup>F‐APN‐1607) in the former professional boxers
The aftermath of boxing: Longitudinal changes of cerebral retention patterns of <sup>18</sup>F‐florzolotau (<sup>18</sup>F‐APN‐1607) in the former professional boxers Open
Background Chronic traumatic encephalopathy (CTE), formerly known as “boxer’s encephalopathy” is a neurodegenerative disease associated with mild‐repetitive TBI. CTE is characterized by the deposition of hyperphosphorylated tau as neurofib…
View article: Involvement of differential tau pathologies in late‐onset bipolar disorder assessed by PET with <sup>18</sup>F‐florzolotau
Involvement of differential tau pathologies in late‐onset bipolar disorder assessed by PET with <sup>18</sup>F‐florzolotau Open
Background Neurodegenerative pathologies, including tau depositions, have been implicated in late‐onset depression (LOD), while there is a lack of in‐vivo evidence for the neuropathological basis of late‐onset bipolar disorder (LOBD) despi…
View article: Development and Comparison of a Novel Mid‐Region Directed p‐Tau 181 Assay with Tau Positron Emission Tomography in Alzheimer’s Disease
Development and Comparison of a Novel Mid‐Region Directed p‐Tau 181 Assay with Tau Positron Emission Tomography in Alzheimer’s Disease Open
Background Several blood‐based phosphorylated tau (p‐tau) assays that focus on the N‐terminus have been developed and established as non‐invasive biomarkers for detecting Alzheimer’s disease (AD) pathologies from their early stages. Howeve…
View article: <i>In vivo</i> characterization of tau accumulation in patients with frontotemporal dementia: A PET study with <sup>18</sup>F‐florzolotau
<i>In vivo</i> characterization of tau accumulation in patients with frontotemporal dementia: A PET study with <sup>18</sup>F‐florzolotau Open
Background Frontotemporal dementia (FTD) is a group of neurodegenerative disorders with diverse clinical and neuropathological features. However, in vivo neuropathological assessments of FTD at an individual level have not hitherto been su…
View article: Open-access database of kinetic parameters in the healthy human brain for existing CNS PET tracers
Open-access database of kinetic parameters in the healthy human brain for existing CNS PET tracers Open
Purpose Information about developed positron emission tomography (PET) tracers and obtained clinical PET images is publicly available in a database. However, findings regarding the kinetic parameters of PET tracers are yet to be summarized…
View article: Development and Performance Assessment of a Novel Plasma p-Tau181 Assay Reflecting Tau Tangle Pathology in Alzheimer’s Disease
Development and Performance Assessment of a Novel Plasma p-Tau181 Assay Reflecting Tau Tangle Pathology in Alzheimer’s Disease Open
Several blood-based assays for phosphorylated tau (p-tau) have been developed to detect brain tau pathologies in Alzheimer’s disease (AD). However, plasma p-tau measured by currently available assays is influenced by brain amyloid and, the…
View article: Tumour status prediction by means of carbon-ion beam irradiation: comparison of washout rates between in-beam PET and DCE-MRI in rats
Tumour status prediction by means of carbon-ion beam irradiation: comparison of washout rates between in-beam PET and DCE-MRI in rats Open
Objective. Tumour response to radiation therapy appears as changes in tumour vascular condition. There are several methods for analysing tumour blood circulatory changes one of which is dynamic contrast-enhanced magnetic resonance imaging …