Chie Takasu
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View article: Feasibility of Robotic Rectal Surgery Using the Hinotori Surgical Robot System
Feasibility of Robotic Rectal Surgery Using the Hinotori Surgical Robot System Open
Patients' characteristics in hinotori and dV cases.
View article: Mechanism of Lenvatinib Resistance via Exosomal <scp>miRNA</scp> ‐132/Nrf2 Axis in Hepatocellular Carcinoma
Mechanism of Lenvatinib Resistance via Exosomal <span>miRNA</span> ‐132/Nrf2 Axis in Hepatocellular Carcinoma Open
Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC). However, its efficacy is insufficient because of acquired resistance. We investigated the role o…
View article: Alteration of Apparent Diffusion Coefficient Measurements Predict Survival Outcomes During Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
Alteration of Apparent Diffusion Coefficient Measurements Predict Survival Outcomes During Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Open
We identified the clinical importance of changes in ADC values as a predictor of survival outcomes in patients with LARC. These results highlight the clinical importance of ADC values on improving the treatment strategies of patients.
View article: Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells
Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells Open
Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation. Epigenetic changes affecting glucose metabolism in cancer‐…
View article: Role of mast cell in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
Role of mast cell in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy Open
The pro-tumor effects of mast cell (MC) in the tumor microenvironment (TME) are becoming increasingly clear. Recently, MC were shown to contribute to tumor malignancy by supporting the migration of tumor-associated macrophages (TAMs), sugg…
View article: The number of teeth is a prognostic indicator for chemotherapy in colorectal cancer
The number of teeth is a prognostic indicator for chemotherapy in colorectal cancer Open
The number of teeth could be easily examined prognostic factor for chemotherapy in colorectal cancer. J. Med. Invest. 72 : 134-138, February, 2025.
View article: Impact of pure desmoplastic histological growth patterns in colorectal liver metastasis
Impact of pure desmoplastic histological growth patterns in colorectal liver metastasis Open
Pure desmoplastic HGP might be a good prognostic marker in CRLM.
View article: Blue light irradiation inhibits the activation of cancer-associated macrophages in colon cancer
Blue light irradiation inhibits the activation of cancer-associated macrophages in colon cancer Open
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy. However, the effects of blue light irradiation on cells in the tumor microenv…
View article: Long-term outcomes and prognostic factors of preoperative chemoradiotherapy with oral dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines in patients with locally advanced rectal cancer
Long-term outcomes and prognostic factors of preoperative chemoradiotherapy with oral dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines in patients with locally advanced rectal cancer Open
Background The purpose of this study was to determine long-term outcomes and prognostic factors in patients with locally advanced rectal cancer who received preoperative chemoradiotherapy with oral dihydropyrimidine dehydrogenase (DPD)-inh…
View article: Role of stromal PD-L1 expression in colorectal liver metastasis
Role of stromal PD-L1 expression in colorectal liver metastasis Open
Background and Aim The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we invest…
View article: Impact of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass
Impact of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass Open
DJB suppressed blood glucose during the early postoperative period. TU-100 may enhance the anti-diabetic effect of metabolic surgery by changing the gut microbiome and suppressing inflammation in the early postoperative period. J. Med. Inv…
View article: Feasibility of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor with tumor diameter of >5 cm
Feasibility of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor with tumor diameter of >5 cm Open
LECS is a feasible option for gastric GISTs with a tumor diameter of > 5 cm. J. Med. Invest. 71 : 148-153, February, 2024.
View article: Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma
Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma Open
Background Cancer-associated fibroblasts (CAFs) have been reported to exhibit protumorigenic effects. Among the well-known CAF markers such as smooth muscle actin (SMA) and fibroblast activation protein (FAP), high expression of SMA in the…
View article: Immune-nutritional indexes for predicting the response to nivolumab immunotherapy in gastric cancer
Immune-nutritional indexes for predicting the response to nivolumab immunotherapy in gastric cancer Open
Background: Immune checkpoint inhibitors reportedly improve survival outcomes in patients with gastric cancer (GC). However, most patients develop disease progression, for which treatment options are limited. Although research has shown so…
View article: Alteration of apparent diffusion coefficient measurements predict survival outcomes during neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Alteration of apparent diffusion coefficient measurements predict survival outcomes during neoadjuvant chemoradiotherapy in locally advanced rectal cancer Open
Background Neoadjuvant chemoradiation therapy (nCRT) followed by surgery is recommended for patients with locally advanced rectal cancer (LARC). However, because 30–40% of patients with LARC do not respond to nCRT, better prediction of tre…
View article: The application of enhanced recovery after surgery in total gastrectomy: a propensity score-matched analysis
The application of enhanced recovery after surgery in total gastrectomy: a propensity score-matched analysis Open
Background This study aimed to investigate the feasibility and safety of our enhanced recovery after surgery protocol including early oral intake and omitting nasogastric tube (NGT) placement after total gastrectomy. Methods We analyzed 18…
View article: Role of stromal PD-L1 expression in colorectal liver metastasis
Role of stromal PD-L1 expression in colorectal liver metastasis Open
Background and Aim The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we invest…
View article: The application of enhanced recovery after surgery in total gastrectomy: a propensity score matched analysis
The application of enhanced recovery after surgery in total gastrectomy: a propensity score matched analysis Open
Background This study aimed to investigate the feasibility and safety of our enhanced recovery after surgery protocol including early oral intake and omitting nasogastric tube (NGT) placement after total gastrectomy. Methods We analyzed 18…
View article: Number of healthy teeth can predict the response of rectal cancer to chemoradiotherapy
Number of healthy teeth can predict the response of rectal cancer to chemoradiotherapy Open
Background: It has been reported that the oral and gut microbiomes are associated with the prognosis in patients who undergo surgery, chemotherapy, and radiation for colorectal cancer. This study is the first to identify a correlation betw…
View article: Utility of robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: transhiatal robotic versus laparoscopic approach
Utility of robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: transhiatal robotic versus laparoscopic approach Open
Background Robotic surgery (RS) has been rapidly adopted for gastric cancer and adenocarcinoma of the esophagogastric junction (AEG). However, the utility of RS for Siewert type II/III AEG remains unclear. Methods Forty-one patients who un…
View article: Effect of duodenal-jejunal bypass on diabetes in the early postoperative period
Effect of duodenal-jejunal bypass on diabetes in the early postoperative period Open
Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative perio…
View article: Factors Correlated with Long-term Weight Loss and DM Remission after Laparoscopic Sleeve Gastrectomy
Factors Correlated with Long-term Weight Loss and DM Remission after Laparoscopic Sleeve Gastrectomy Open
Background The aim of this study is to investigate the factors correlated with long-term weight loss and diabetes mellitus (DM) remission after laparoscopic sleeve gastrectomy (LSG). Methods Sixteen obese patients who underwent LSG were en…
View article: Impact of L-type amino acid transporter 1 on intrahepatic cholangiocarcinoma
Impact of L-type amino acid transporter 1 on intrahepatic cholangiocarcinoma Open
LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023.