Chieh-En Jane Tseng
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View article: Choroid plexus alterations in autism spectrum disorder: A PET-MRI study
Choroid plexus alterations in autism spectrum disorder: A PET-MRI study Open
The choroid plexus (CP), primarily known as the production site of cerebrospinal fluid (CSF), constitutes one of the sites of the blood-CSF barrier and plays a unique role in inflammation propagation, serving as a key regulator of immune r…
View article: Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces
Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the gray-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no
View article: Speech motor impairment in ALS is associated with multiregional cortical thinning beyond primary motor cortex
Speech motor impairment in ALS is associated with multiregional cortical thinning beyond primary motor cortex Open
Introduction Cortical thinning is well-documented in individuals with amyotrophic lateral sclerosis (ALS), yet its association with speech deterioration remains understudied. This study characterizes anatomical changes in the brain within …
View article: Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study
Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study Open
View article: Neural Network Correlates of Apathy, Disinhibition, and Executive Dysfunction in Active-Duty United States Special Operations Forces
Neural Network Correlates of Apathy, Disinhibition, and Executive Dysfunction in Active-Duty United States Special Operations Forces Open
United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 2…
View article: Neuroinflammation at the Grey-White Matter Interface in Active-Duty United States Special Operations Forces
Neuroinflammation at the Grey-White Matter Interface in Active-Duty United States Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the grey-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no ne…
View article: Impact of repeated blast exposure on active-duty United States Special Operations Forces
Impact of repeated blast exposure on active-duty United States Special Operations Forces Open
United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood. Furthermore, there is n…
View article: In vivo translocator protein in females with autism spectrum disorder: a pilot study
In vivo translocator protein in females with autism spectrum disorder: a pilot study Open
View article: Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation
Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation Open
View article: Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation
Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation Open
BACKGROUND: Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA, reward circui…
View article: Striatal Dopamine Binding in Anhedonia: A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation
Striatal Dopamine Binding in Anhedonia: A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation Open
Background Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA binding, reward…
View article: Long-Term Effects of Repeated Blast Exposure in United States Special Operations Forces Personnel: A Pilot Study Protocol
Long-Term Effects of Repeated Blast Exposure in United States Special Operations Forces Personnel: A Pilot Study Protocol Open
Emerging evidence suggests that repeated blast exposure (RBE) is associated with brain injury in military personnel. United States (U.S.) Special Operations Forces (SOF) personnel experience high rates of blast exposure during training and…
View article: The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic
The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic Open
View article: The Pandemic Brain: neuroinflammation in healthy, non-infected individuals during the COVID-19 pandemic
The Pandemic Brain: neuroinflammation in healthy, non-infected individuals during the COVID-19 pandemic Open
Summary Background The impact of COVID-19 on human health extends beyond the morbidity and death toll directly caused by the SARS-CoV-2 virus. In fact, accumulating evidence indicates a global increase in the incidence of fatigue, brain fo…
View article: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism
A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism Open
View article: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism
A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism Open
The social motivation hypothesis of autism posits that autism spectrum disorder (ASD) is characterized by impaired motivation to seek out social experience early in life that interferes with the development of social functioning. This fram…
View article: Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial
Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial Open
View article: A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation of Striatal Dopamine Binding in Autism
A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation of Striatal Dopamine Binding in Autism Open
Background The social motivation hypothesis of autism suggests that autism spectrum disorder (ASD) is characterized by impaired motivation to seek out social experience early in life that interferes with the development of social functioni…
View article: In vivo human brain expression of histone deacetylases in bipolar disorder
In vivo human brain expression of histone deacetylases in bipolar disorder Open
View article: Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands
Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands Open
Neuroinflammation has been implicated in amyotrophic lateral sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, TSPO radioligands…
View article: [11C]PBR28 MR–PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder
[11C]PBR28 MR–PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder Open
View article: Working Memory Training Is Associated with Changes in Resting State Functional Connectivity in Children Who Were Born Extremely Preterm: a Randomized Controlled Trial
Working Memory Training Is Associated with Changes in Resting State Functional Connectivity in Children Who Were Born Extremely Preterm: a Randomized Controlled Trial Open
Children born extremely preterm (EP; < 28 weeks of gestation) or extremely low birth weight (ELBW; < 1000 g) are at increased risk of working memory deficits compared with their term-born peers and may benefit from working memory training.…
View article: Neuroepigenetic signatures of age and sex in the living human brain
Neuroepigenetic signatures of age and sex in the living human brain Open
Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene transcription in the brain. Here, we measure in vivo expression of the …
View article: Verbal Fluency Is Affected by Altered Brain Lateralization in Adults Who Were Born Very Preterm
Verbal Fluency Is Affected by Altered Brain Lateralization in Adults Who Were Born Very Preterm Open
Language difficulties have been reported in children and adolescents who were born very preterm ( Rest and Hard > Rest conditions, compared to controls, in superior temporal gyrus (STG), insula, thalamus, and sensorimotor cortex, particula…
View article: A dimensional approach to assessing psychiatric risk in adults born very preterm
A dimensional approach to assessing psychiatric risk in adults born very preterm Open
Background Individuals who were born very preterm have higher rates of psychiatric diagnoses compared with term-born controls; however, it remains unclear whether they also display increased sub-clinical psychiatric symptomatology. Hence, …
View article: Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation
Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation Open
View article: A Dimensional Approach to Assessing Psychiatric Risk in Adults Born Very Preterm
A Dimensional Approach to Assessing Psychiatric Risk in Adults Born Very Preterm Open
Background Individuals who were born very preterm have higher rates of psychiatric diagnoses compared to term-born controls; however, it remains unclear whether they also display increased sub-clinical psychiatric symptomatology. Hence our…
View article: Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation
Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation Open
Previous research investigating structural neurodevelopmental alterations in individuals who were born very preterm demonstrated a complex pattern of grey matter changes that defy straightforward summary. Here we addressed this problem by …
View article: White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions
White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions Open
View article: Hippocampal Atrophy Is Associated with Altered Hippocampus–Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Hippocampal Atrophy Is Associated with Altered Hippocampus–Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis Open
In left mesial temporal lobe epilepsy with hippocampal sclerosis, the left inferior cingulum bundle undergoes degeneration in tandem with the left hippocampal volume, whereas intrinsic functional connectivity seems to react by compensating…