Chieko Mishima
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View article: Targeting focal adhesion kinase inhibits cell migration and non-angiogenic vascularization in malignant breast cancer
Targeting focal adhesion kinase inhibits cell migration and non-angiogenic vascularization in malignant breast cancer Open
Background High-grade carcinomas, including breast cancer, are associated with angiogenesis and non-angiogenic vascularization. Non-angiogenic vascularization enhances blood flow, tumor growth, and metastasis. Although inhibition of focal …
View article: The Impact of Lymphoscintigraphy Visualization on the Prognosis of Early Breast Cancer Patients Undergoing Sentinel Node Biopsy: A 20-year, Single-center Experience.
The Impact of Lymphoscintigraphy Visualization on the Prognosis of Early Breast Cancer Patients Undergoing Sentinel Node Biopsy: A 20-year, Single-center Experience. Open
Lymphoscintigraphy visualization status was not significantly associated with OS and RFS in patients with early breast cancer undergoing SLNB. This suggests that nonvisualization does not indicate a greater tumor burden or poorer prognosis…
View article: High HER2 Intratumoral Heterogeneity Is Resistant to Anti-HER2 Neoadjuvant Chemotherapy in Early Stage and Locally Advanced HER2-Positive Breast Cancer
High HER2 Intratumoral Heterogeneity Is Resistant to Anti-HER2 Neoadjuvant Chemotherapy in Early Stage and Locally Advanced HER2-Positive Breast Cancer Open
Background/Objectives: Breast cancer tumors possess intratumoral heterogeneity (ITH), which is associated with therapeutic resistance. Tumors with high ITH exhibit human epidermal growth factor receptor 2 (HER2) heterogeneity, affecting th…
View article: P055: Rapid and Accurate Diagnosis of Breast Cancer by Fine-Needle Aspiration Biopsy Using the “Click-to-Sense” Method
P055: Rapid and Accurate Diagnosis of Breast Cancer by Fine-Needle Aspiration Biopsy Using the “Click-to-Sense” Method Open
View article: P035: Establishment of Newly Rapid and Accurate Intra-operative Examination of the Surgical Margin Status in Breast-Conserving Surgery by “Click-to-sense” Assay
P035: Establishment of Newly Rapid and Accurate Intra-operative Examination of the Surgical Margin Status in Breast-Conserving Surgery by “Click-to-sense” Assay Open
View article: Impact of Using Intraoperative Nomograms with One-Step Nucleic Acid Amplification to Omit Axillary Lymph Node Dissection in Patients with Breast Cancer Who Underwent Mastectomy
Impact of Using Intraoperative Nomograms with One-Step Nucleic Acid Amplification to Omit Axillary Lymph Node Dissection in Patients with Breast Cancer Who Underwent Mastectomy Open
View article: Evaluation of Targeted Alpha Therapy Using [211At]FAPI1 in Triple-Negative Breast Cancer Xenograft Models
Evaluation of Targeted Alpha Therapy Using [211At]FAPI1 in Triple-Negative Breast Cancer Xenograft Models Open
Triple-negative breast cancer (TNBC) presents limited therapeutic options and is associated with poor prognosis. Early detection and the development of novel therapeutic agents are therefore imperative. Fibroblast activation protein (FAP) …
View article: Rapid and Accurate Diagnosis of Breast Cancer by Fine-Needle Aspiration Biopsy Using the “Click-to-Sense” Method
Rapid and Accurate Diagnosis of Breast Cancer by Fine-Needle Aspiration Biopsy Using the “Click-to-Sense” Method Open
We have previously demonstrated the value of the “click-to-sense” (CTS) assay, in which a fluorescent probe targeting acrolein can detect cancer cells and differentiate between malignant and benign lesions in breast tissue. In this study, …
View article: Breast Cancer with IgA Vasculitis due to Endocrine Therapy in an Elderly Female Undergoing Postoperative—A Case Report—
Breast Cancer with IgA Vasculitis due to Endocrine Therapy in an Elderly Female Undergoing Postoperative—A Case Report— Open
症例は82歳，女性．右乳癌の診断で乳房部分切除術とセンチネルリンパ節生検を施行．術後病理学的診断でホルモン受容体陽性であったため，術後内分泌療法としてアナストロゾール（ANA）内服を開始した．内服開始後9カ月，両下腿浮腫，上気道炎症状に続き下肢紫斑，下腹部痛が出現したため，精査加療目的に当院へ入院となった．病歴より血管炎を疑い，下腿紫斑より皮膚生検を行ったところ，IgA，C3の沈着を伴う血管壁の炎症を認め，薬剤性のIgA血管炎と診断した．被疑薬であるANA中止後，速やかに紫…
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Table of Contents Open
View article: Mutational Analysis of AKT1 and PIK3CA in Intraductal Papillomas of the Breast with Special Reference to Cellular Components
Mutational Analysis of AKT1 and PIK3CA in Intraductal Papillomas of the Breast with Special Reference to Cellular Components Open
View article: LATS2 promoter hypermethylation and its effect on gene expression in human breast cancer
LATS2 promoter hypermethylation and its effect on gene expression in human breast cancer Open
Tumor-specific promoter hypermethylation of large tumor suppressor, homolog 2 (LATS2), a tumor suppressor gene, has been investigated using methylation-specific polymerase chain reaction (MSP) assays in different types of human canc…
View article: Methylation of the SEPT9_v2 promoter as a novel marker for the detection of circulating tumor DNA in breast cancer patients
Methylation of the SEPT9_v2 promoter as a novel marker for the detection of circulating tumor DNA in breast cancer patients Open
The aim of the present study was to evaluate the promoter methylation status of SEPT9_v2 in breast cancer and to detect this methylated gene in circulating tumor DNA (ctDNA) in plasma. Bisulfite sequencing was performed with a next generat…
View article: Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast
Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast Open
Loss of imprinting (LOI) of insulin-like growth factor 2 (IGF2) is thought to be implicated in the pathogenesis of some tumors by upregulating IGF2 mRNA but its role in the pathogenesis of fibroadenomas (FAs) and phyllodes tumors (PTs) of …
View article: Promoter methylation of TRIM9 as a marker for detection of circulating tumor DNA in breast cancer patients
Promoter methylation of TRIM9 as a marker for detection of circulating tumor DNA in breast cancer patients Open