C.H. Chen
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View article: SLC38A1 as a novel therapeutic target in upper tract urothelial carcinoma via regulating cell proliferation and migration through suppressing Akt/mTOR signaling
SLC38A1 as a novel therapeutic target in upper tract urothelial carcinoma via regulating cell proliferation and migration through suppressing Akt/mTOR signaling Open
Upper tract urothelial carcinoma (UTUC) has specific high prevalence in Asian population and, compared to bladder cancer, there are unique etiologic and genomic factors contributing to its tumorigenesis. Although up-regulation of sodium-co…
View article: Combining serum inflammatory markers and clinical factors to predict survival in metastatic urothelial carcinoma patients treated with immune checkpoint inhibitors
Combining serum inflammatory markers and clinical factors to predict survival in metastatic urothelial carcinoma patients treated with immune checkpoint inhibitors Open
Background: Despite the revolutionary impact of immune checkpoint inhibitors (ICIs) on the treatment of metastatic urothelial carcinoma (mUC), the clinical utility of reliable prognostic biomarkers to foresee survival outcomes remains unde…
View article: Laparoendoscopic Single-Site Inguinal Herniorrhaphy: Experience of a Single Institute
Laparoendoscopic Single-Site Inguinal Herniorrhaphy: Experience of a Single Institute Open
Background: Minimally invasive techniques for inguinal herniorrhaphy have focused on developing the laparoendoscopic single-site (LESS) procedure to improve cosmesis. Outcomes of total extraperitoneal (TEP) herniorrhaphy vary considerably …
View article: Treatment outcomes with radium-223 in docetaxel-naïve versus docetaxel-treated metastatic castration-resistant prostate cancer patients: Real-world evidence from Taiwan
Treatment outcomes with radium-223 in docetaxel-naïve versus docetaxel-treated metastatic castration-resistant prostate cancer patients: Real-world evidence from Taiwan Open
While radium (Ra)-223 is among the multiple, known life-prolonging treatments in bone-predominant metastatic castration-resistant prostate cancer (mCRPC), optimal treatment sequencing has not been determined, particularly in the Asia-Pacif…
View article: Nanodiamonds Doped with Manganese for Applications in Magnetic Resonance Imaging
Nanodiamonds Doped with Manganese for Applications in Magnetic Resonance Imaging Open
Nanodiamonds (NDs) are emerging with great potential in biomedical applications like biomarking through fluorescence and magnetic resonance imaging (MRI), targeted drug delivery, and cancer therapy. The magnetic and optical properties of N…
View article: Proton FLASH irradiation platform for small animal setup at Chang Gung Memorial Hospital
Proton FLASH irradiation platform for small animal setup at Chang Gung Memorial Hospital Open
Background : Proton flash therapy is an emergency research topic in radiation therapy since the Varian announced the promising results from the first in human clinical trial of Flash therapy recently. However, it still needs a lot of resea…
View article: Totally X-ray-Free Ultrasound-Guided Mini-Percutaneous Nephrolithotomy in Galdakao-Modified Supine Valdivia Position: A Novel Combined Surgery
Totally X-ray-Free Ultrasound-Guided Mini-Percutaneous Nephrolithotomy in Galdakao-Modified Supine Valdivia Position: A Novel Combined Surgery Open
We introduced a novel surgery that combines ultrasound guidance, miniaturization and Galdakao-modified supine Valdivia (GMSV) position in percutaneous nephrolithotomy (PCNL) and evaluated the safety and efficacy. This retrospective, single…
View article: Convolutional Neural Networks to Classify Alzheimer’s Disease Severity Based on SPECT Images: A Comparative Study (Preprint)
Convolutional Neural Networks to Classify Alzheimer’s Disease Severity Based on SPECT Images: A Comparative Study (Preprint) Open
BACKGROUND Image-based recognition has become a long-term topic in the field of artificial intelligence, and neuroimaging has gradually become a beneficial way to understand the course of Alzheimer’s disease (AD). OBJECTIVE The goal of …
View article: Comparison of Robot-Assisted Laparoscopic Partial Nephrectomy with Laparoscopic Cryoablation in the Treatment of Localised Renal Tumours: A Propensity Score-Matched Comparison of Long-Term Outcomes
Comparison of Robot-Assisted Laparoscopic Partial Nephrectomy with Laparoscopic Cryoablation in the Treatment of Localised Renal Tumours: A Propensity Score-Matched Comparison of Long-Term Outcomes Open
Preserving renal function and controlling oncological outcomes are pertinent when managing renal neoplasms. Cryoablation is the recommended treatment only for clinical T1a stage renal tumour. Here, we compared the outcomes of robot-assiste…
View article: Promise and the Pharmacological Mechanism of Botulinum Toxin A in Chronic Prostatitis Syndrome
Promise and the Pharmacological Mechanism of Botulinum Toxin A in Chronic Prostatitis Syndrome Open
Chronic prostatitis/chronic pelvic pain syndrome (CP/ CPPS) has a negative impact on the quality of life, and its etiology still remains unknown. Although many treatment protocols have been evaluated in CP/CPPS, the outcomes have usually b…
View article: Process Verification of Magnetic Ion Embedded Nanodiamonds Using Secondary Ion Mass Spectroscopy
Process Verification of Magnetic Ion Embedded Nanodiamonds Using Secondary Ion Mass Spectroscopy Open
Ion implantation is used to create magnetic ion embedded nanodiamonds for use in a wide range of biological and medical applications; however, the effectiveness of this process depends heavily on separating magnetic nanodiamonds from non-m…
View article: High Resolution and High Precision Beam Profile Monitor for Particle Accelerator using linear contact image sensor
High Resolution and High Precision Beam Profile Monitor for Particle Accelerator using linear contact image sensor Open
A compact beam-profile monitor was constructed using a linear contact image sensor attached to a plastic scintillator and tested using a 230 MeV proton beam. The results indicate that the beam distribution can be obtained in real-time, and…
View article: Fluorescent <sup>10</sup>B embedded nanodiamonds as <sup>10</sup>B delivery agent for boron neutron capture therapy
Fluorescent <sup>10</sup>B embedded nanodiamonds as <sup>10</sup>B delivery agent for boron neutron capture therapy Open
Boron neutron capture therapy is a powerful anti-cancer treatment, the\nsuccess of which depends heavily on the boron delivery agent. Enabling the\nreal-time tracing of delivery agents as they move through the body is crucial\nto the furth…
View article: The extracellular domain of epithelial cell adhesion molecule (EpCAM) enhances multipotency of mesenchymal stem cells through EGFR–LIN28–LET7 signaling
The extracellular domain of epithelial cell adhesion molecule (EpCAM) enhances multipotency of mesenchymal stem cells through EGFR–LIN28–LET7 signaling Open
Mesenchymal stem cells (MSCs) are widely considered to be an attractive cell source for regenerative therapies, but maintaining multipotency and self-renewal in cultured MSCs is especially challenging. Hence, the development and mechanisti…
View article: Fluorescent Fe Embedded Magnetic Nanodiamonds Made by Ion Implantation
Fluorescent Fe Embedded Magnetic Nanodiamonds Made by Ion Implantation Open
We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after the implantation process. Aft…
View article: Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI Open
We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new co…