Chih-Po Hsu
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View article: The impact of single-nucleotide variants of hepatitis B virus and antiviral on liver cancer in gray zone patients
The impact of single-nucleotide variants of hepatitis B virus and antiviral on liver cancer in gray zone patients Open
Objectives This study investigated the impact and related mechanisms of single-nucleotide variants (SNVs) in the HBV pre-S/S region on tumor development, and evaluated the role of antiviral therapy. Methods A retrospective analysis was con…
View article: Retrospective cohort analysis of low-molecular-weight heparin versus non-vitamin k antagonist oral anticoagulants for venous thromboembolism prophylaxis across racial groups in hospitalized trauma patients
Retrospective cohort analysis of low-molecular-weight heparin versus non-vitamin k antagonist oral anticoagulants for venous thromboembolism prophylaxis across racial groups in hospitalized trauma patients Open
Background: Venous thromboembolism (VTE) is a significant risk factor for trauma, and low-molecular-weight heparin (LMWH) is the standard prophylactic treatment. Although direct oral anticoagulants (DOACs) may be convenient, their comparat…
View article: Early laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage in acute cholecystitis is appropriate and safe: an inverse probability of treatment weighting analysis
Early laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage in acute cholecystitis is appropriate and safe: an inverse probability of treatment weighting analysis Open
Early LC after PTGBD during the same admission is a viable alternative to delayed LC, reducing hospital stay and complications. Immediate LC remains the preferred approach for eligible patients without prior PTGBD. Further prospective stud…
View article: Surgical stabilization of rib fractures improves survival in functionally dependent trauma patients
Surgical stabilization of rib fractures improves survival in functionally dependent trauma patients Open
SSRF in functionally dependent trauma patients with multiple rib fractures and significant chest wall injury (AIS ≥ 3) is associated with a significant reduction in in-hospital mortality compared to conservative management, despite a highe…
View article: Early Laparoscopic Cholecystectomy after Percutaneous Transhepatic Gallbladder Drainage in Acute Cholecystitis is Appropriate and Safe: An Inverse Probability of Treatment Weighting Analysis
Early Laparoscopic Cholecystectomy after Percutaneous Transhepatic Gallbladder Drainage in Acute Cholecystitis is Appropriate and Safe: An Inverse Probability of Treatment Weighting Analysis Open
Background: Acute cholecystitis (AC) is a common emergency requiring timely surgical intervention. While laparoscopic cholecystectomy (LC) is the standard treatment, the optimal timing for LC following percutaneous transhepatic gallbladder…
View article: Surgical Rib Fixation Improves Survival in Functionally Dependent Trauma Patients
Surgical Rib Fixation Improves Survival in Functionally Dependent Trauma Patients Open
Background Rib fractures are frequently encountered in trauma care and are particularly hazardous for functionally dependent patients, leading to increased morbidity and mortality rates. Surgical rib fixation (SRF) improves outcomes in sel…
View article: Comparative efficacy of venous thromboembolism prophylaxis in patients with blunt trauma: Direct thrombin inhibitors vs low-molecular-weight heparin
Comparative efficacy of venous thromboembolism prophylaxis in patients with blunt trauma: Direct thrombin inhibitors vs low-molecular-weight heparin Open
Background/objective: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE) and poses a risk to patients with trauma. This study compared the efficacy of direct thrombin inhibitors (DTIs) and low-mole…
View article: Total care of trauma patients from triage to discharge at Chang Gung Memorial Hospital: introducing the development of an iconic acute care surgery system in Taiwan
Total care of trauma patients from triage to discharge at Chang Gung Memorial Hospital: introducing the development of an iconic acute care surgery system in Taiwan Open
The emergence of the ACS model aims to reverse the decline in the trauma field that began decades ago. This model not only helps retain skilled professionals but also maintains the expertise of trauma surgeons, ensuring that trauma patient…
View article: Long-term follow-up of infection, malignancy, thromboembolism, and all-cause mortality risks after splenic artery embolization for blunt splenic injury: comparison with splenectomy and conservative management
Long-term follow-up of infection, malignancy, thromboembolism, and all-cause mortality risks after splenic artery embolization for blunt splenic injury: comparison with splenectomy and conservative management Open
Background Non-operative management, including splenic artery embolization, is preferred for blunt splenic injuries, but its long-term risks need further investigation. Long-term splenic functions were assessed in patients with blunt splen…
View article: Fixation of rib fractures is beneficial for patients with chronic obstructive pulmonary disease, a trauma quality improvement program study
Fixation of rib fractures is beneficial for patients with chronic obstructive pulmonary disease, a trauma quality improvement program study Open
View article: Evaluating the clinical impact of resuscitative endovascular balloon occlusion of the aorta in patients with blunt trauma with hemorrhagic shock and coexisting traumatic brain injuries: a retrospective cohort study
Evaluating the clinical impact of resuscitative endovascular balloon occlusion of the aorta in patients with blunt trauma with hemorrhagic shock and coexisting traumatic brain injuries: a retrospective cohort study Open
Background: The impact of resuscitative endovascular balloon occlusion of the aorta (REBOA) on traumatic brain injuries remains uncertain, with potential outcomes ranging from neuroprotection to exacerbation of the injury. The study aimed …
View article: Management of acute cholecystitis in patients older than the expected life expectancy: Is the Tokyo Guidelines 2018 still practical?
Management of acute cholecystitis in patients older than the expected life expectancy: Is the Tokyo Guidelines 2018 still practical? Open
Background As the global population ages, the incidence of acute cholecystitis is increasing. Tokyo Guidelines 2018 are established as the standard for managing this condition. However, the applicability in elderly patients, who often have…
View article: Deep Learning for Automated Detection and Localization of Traumatic Abdominal Solid Organ Injuries on CT Scans
Deep Learning for Automated Detection and Localization of Traumatic Abdominal Solid Organ Injuries on CT Scans Open
Computed tomography (CT) is the most commonly used diagnostic modality for blunt abdominal trauma (BAT), significantly influencing management approaches. Deep learning models (DLMs) have shown great promise in enhancing various aspects of …
View article: Low-molecular-weight heparin is associated with lower venous thromboembolism events than factor Xa inhibitors in patients with severe blunt trauma: a cohort study from the Trauma Quality Improvement Program
Low-molecular-weight heparin is associated with lower venous thromboembolism events than factor Xa inhibitors in patients with severe blunt trauma: a cohort study from the Trauma Quality Improvement Program Open
Background: Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is a common complication of major trauma. Pharmacological VTE prophylactics are widely used, and low-molecular-weight heparin (LM…
View article: Long-term survival after major trauma: a retrospective nationwide cohort study from the National Health Insurance Research Database
Long-term survival after major trauma: a retrospective nationwide cohort study from the National Health Insurance Research Database Open
Background: Most trauma-related studies are focused on short-term survival and complications within the index admission, and the long-term outcomes beyond discharge are mainly unknown. The purpose of this study was to analyze the data from…
View article: Identification and Clinical Significance of Pancreatic Cancer Stem Cells and Their Chemotherapeutic Drug Resistance
Identification and Clinical Significance of Pancreatic Cancer Stem Cells and Their Chemotherapeutic Drug Resistance Open
Pancreatic cancer ranks in the 10th–11th position among cancers affecting men in Taiwan, besides being a rather difficult-to-treat disease. The overall 5-year survival rate of pancreatic cancer is only 5–10%, while that of resectable pancr…
View article: Timely surgical fixation confers beneficial outcomes in patients’ concomitant flail chest with mild-to-moderate traumatic brain injury: a trauma quality improvement project analysis – a cohort study
Timely surgical fixation confers beneficial outcomes in patients’ concomitant flail chest with mild-to-moderate traumatic brain injury: a trauma quality improvement project analysis – a cohort study Open
Background: Traumatic flail chest results in respiratory distress and prolonged hospital stay. Timely surgical fixation of the flail chest reduces respiratory complications, decreases ventilator dependence, and shortens hospital stays. Con…
View article: The three-dimensional weakly supervised deep learning algorithm for traumatic splenic injury detection and sequential localization: an experimental study
The three-dimensional weakly supervised deep learning algorithm for traumatic splenic injury detection and sequential localization: an experimental study Open
Background: Splenic injury is the most common solid visceral injury in blunt abdominal trauma, and high-resolution abdominal computed tomography (CT) can adequately detect the injury. However, these lethal injuries sometimes have been over…
View article: Evaluation of ensemble strategy on the development of multiple view ankle fracture detection algorithm
Evaluation of ensemble strategy on the development of multiple view ankle fracture detection algorithm Open
Objective: To identify the feasibility and efficiency of deep convolutional neural networks (DCNNs) in the detection of ankle fractures and to explore ensemble strategies that applied multiple projections of radiographs. Ankle radiographs …
View article: Taiwan cobra envenoming: serum venom concentration before and after specific treatment and relationship with debridement of necrotic wound tissue
Taiwan cobra envenoming: serum venom concentration before and after specific treatment and relationship with debridement of necrotic wound tissue Open
Antivenom can efficiently eliminate the circulating cobra venom in limb swelling patients without wound necrosis. Early debridement of the bite site wound and wet dressing management are suggestions for preventing extended tissue necrosis …
View article: Taiwan cobra envenoming: serum venom concentration before and after specific treatment and relationship with debridement of necrotic wound tissue
Taiwan cobra envenoming: serum venom concentration before and after specific treatment and relationship with debridement of necrotic wound tissue Open
Background: Bivalent freeze-dried neurotoxic (FN) antivenom has been the primary treatment since the 1980s for Taiwan cobra (Naja atra) envenomation in Taiwan. However, envenomation-related wound necrosis is a significant problem after cob…
View article: Secure reconstruction after pancreaticoduodenectomy: Review and improved our continuous duct-to-mucosa anastomosis
Secure reconstruction after pancreaticoduodenectomy: Review and improved our continuous duct-to-mucosa anastomosis Open
Pancreatic anastomotic leakage is the most common major complication after pancreaticoduodenectomy (PD). The incidence of pancreatic anastomotic leak or fistula has declined to less than 20%, and mortality from this complication has decrea…
View article: The Clinical Application of Machine Learning-Based Models for Early Prediction of Hemorrhage in Trauma Intensive Care Units
The Clinical Application of Machine Learning-Based Models for Early Prediction of Hemorrhage in Trauma Intensive Care Units Open
Uncontrolled post-traumatic hemorrhage is an important cause of traumatic mortality that can be avoided. This study intends to use machine learning (ML) to build an algorithm based on data collected from an electronic health record (EHR) s…
View article: Validation of a five-level triage system in pediatric trauma and the effectiveness of triage nurse modification: A multi-center cohort analysis
Validation of a five-level triage system in pediatric trauma and the effectiveness of triage nurse modification: A multi-center cohort analysis Open
Introduction Triage is one of the most important tasks for nurses in a modern emergency department (ED) and it plays a critical role in pediatric trauma. An appropriate triage system can improve patient outcomes and decrease resource wasti…
View article: The Surgical Timing and Complications of Rib Fixation for Rib Fractures in Geriatric Patients
The Surgical Timing and Complications of Rib Fixation for Rib Fractures in Geriatric Patients Open
Rib fractures (RF) are a common injury that cause significant morbidity and mortality, especially in geriatric patients. RF fixation could shorten hospital stay and improve survival. The aim of this retrospective study was to evaluate the …
View article: A novel scoring system using easily assessible predictors of return of spontaneous circulation and mortality in traumatic out-of-hospital cardiac arrest patients: A retrospective cohort study
A novel scoring system using easily assessible predictors of return of spontaneous circulation and mortality in traumatic out-of-hospital cardiac arrest patients: A retrospective cohort study Open
Termination of CPR for TOHCA after 45 min is reasonable; a 30-min resuscitation is acceptable in case of insufficient medical staff or resources. The TOHCA score may be able to be used with caution for triage.
View article: Spleen size greater than 9.76 cm may impact the treatment strategy for blunt splenic injury in adults - A retrospective analysis of experience at a tertiary trauma center in Taiwan
Spleen size greater than 9.76 cm may impact the treatment strategy for blunt splenic injury in adults - A retrospective analysis of experience at a tertiary trauma center in Taiwan Open
Splenomegaly is an independent predictor for the requirement of hemostatic treatments in blunt splenic injury patients, especially transarterial embolization. Transarterial embolization is as effective for blunt splenic injury patients wit…
View article: The Impact on the Clinical Prognosis of Low Serum Selenium Level in Patients with Severe Trauma: Systematic Review and Meta-Analysis
The Impact on the Clinical Prognosis of Low Serum Selenium Level in Patients with Severe Trauma: Systematic Review and Meta-Analysis Open
This study was designed to examine the most up-to-date evidence about how low plasma selenium (Se) concentration affects clinical outcomes, such as mortality, infectious complications, and length of ICU or hospital stay, in patients with m…
View article: The Impact of Selenium Supplementation on Trauma Patients—Systematic Review and Meta-Analysis
The Impact of Selenium Supplementation on Trauma Patients—Systematic Review and Meta-Analysis Open
This study aimed to assess current evidence regarding the effect of selenium (Se) supplementation on the prognosis in patients sustaining trauma. MEDLINE, Embase, and Web of Science databases were searched with the following terms: “trace …
View article: The Severity of Postoperative Pancreatic Fistula Predicts 30-Day Unplanned Hospital Visit and Readmission after Pancreaticoduodenectomy: A Single-Center Retrospective Cohort Study
The Severity of Postoperative Pancreatic Fistula Predicts 30-Day Unplanned Hospital Visit and Readmission after Pancreaticoduodenectomy: A Single-Center Retrospective Cohort Study Open
Background: Unplanned hospital visits (UHV) and readmissions after pancreaticoduodenectomy (PD) impact patients’ postoperative recovery and are associated with increased financial burden and morbidity. The aim of this study is to identify …