Chihiro Tani Sassa
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View article: Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases Open
Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly inv…
View article: Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution Open
View article: Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity Open
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononu…
View article: The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force Open
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dyna…
View article: Complete Genome Sequence of an Enterobacter roggenkampii Strain with Reduced Carbapenem Susceptibility Isolated from a Home-Visit Nursing Agency
Complete Genome Sequence of an Enterobacter roggenkampii Strain with Reduced Carbapenem Susceptibility Isolated from a Home-Visit Nursing Agency Open
Carbapenem-resistant bacteria represent an emerging threat to global health; nursing homes may be reservoirs for these isolates, which cause life-threatening infections. Here, we present the complete genome sequence of an Enterobacter rogg…
View article: DOCK2 is involved in the host genetics and biology of severe COVID-19
DOCK2 is involved in the host genetics and biology of severe COVID-19 Open
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1–5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during …
View article: Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan
Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan Open
To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (G…
View article: Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic <i>Escherichia coli</i> in Ghana
Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic <i>Escherichia coli</i> in Ghana Open
The emergence and spread of carbapenemase-producing bacteria are serious threats to public health. We characterized two OXA-181-producing Escherichia coli isolates from pediatric patients with diarrhea from Ghana. blaOXA…
View article: Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic <i>Escherichia coli</i> in Ghana
Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic <i>Escherichia coli</i> in Ghana Open
The emergence and spread of carbapenemase-producing bacteria are serious threats to public health. We characterized two OXA-181-producing Escherichia coli isolates from pediatric patients with diarrhea from Ghana. blaOXA…