Chimeg Erdenebat
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View article: Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB Open
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple pathways. Whether transcription blockage contributes to the toxicity of DPCs and how cells respond when RNA polymerases sta…
View article: DPC-seq enables genome-wide monitoring of DNA-protein crosslink induction and repair
DPC-seq enables genome-wide monitoring of DNA-protein crosslink induction and repair Open
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions arising from a variety of endogenous and exogenous genotoxins including chemotherapeutic drugs. DPCs can be enzymatic or non-enzymatic in nature, with non-enzymatic DPCs arising fr…
View article: <i>B. subtilis</i>MutS2 splits stalled ribosomes into subunits without mRNA cleavage
<i>B. subtilis</i>MutS2 splits stalled ribosomes into subunits without mRNA cleavage Open
Stalled ribosomes are rescued by pathways that recycle the ribosome and target the nascent polypeptide for degradation. In E. coli , these pathways are triggered by ribosome collisions through recruitment of SmrB, a nuclease that cleaves t…