Chin‐Chung Wu
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View article: To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization
To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization Open
G protein-coupled receptors (GPCRs) are key therapeutic targets for various diseases, such as the thrombin receptor protease-activated receptor 4 (PAR4) involved in thrombotic cardiovascular disorders. However, the structural complexity of…
View article: The Pontoon Design Optimization of a SWATH Vessel for Resistance Reduction
The Pontoon Design Optimization of a SWATH Vessel for Resistance Reduction Open
This study applies a deep neural network (DNN) to optimize the 22.5 m pontoon hull form of a small waterplane area twin hull (SWATH) vessel with fin stabilizers, aiming to reduce calm water resistance at a Froude number of 0.8 under even k…
View article: To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization
To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization Open
G protein-coupled receptors (GPCRs) are key therapeutic targets for various diseases, such as the thrombin receptor protease-activated receptor 4 (PAR4) in thrombotic cardiovascular disorders. The structural complexity of native GPCRs limi…
View article: Development and validation of a five-year cardiovascular risk assessment tool for Asian adults aged 75 years and older
Development and validation of a five-year cardiovascular risk assessment tool for Asian adults aged 75 years and older Open
This sex-specific CV risk assessment tool shows fair discriminative capability in estimating risk of cardiovascular disease among elderly Asians, potentially enabling targeted interventions in this vulnerable population.
View article: Long-term prognostic effect of serum albumin concentration in diabetic patients with stable coronary artery disease: A multicenter cohort study
Long-term prognostic effect of serum albumin concentration in diabetic patients with stable coronary artery disease: A multicenter cohort study Open
Background: Diabetes and insulin resistance alter the physiological state of serum albumin (SA), which is a prognostic marker for stable coronary artery disease (CAD). However, whether the SA concentration is associated with long-term card…
View article: Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition
Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition Open
In this study, a series of 2- and/or 3-substituted juglone derivatives were designed and synthesized. Among them, 9, 18, 22, 30, and 31 showed stronger inhibition activity against cell surface PDI or reco…
View article: Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 75KB.
View article: Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
DNA damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR)-dependent phosphorylation of Chk2 and Chk1 kinases, which are hallmarks of the DNA damage response (DDR).…
View article: Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 984KB.
View article: Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 75KB.
View article: Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 984KB.
View article: Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
DNA damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR)-dependent phosphorylation of Chk2 and Chk1 kinases, which are hallmarks of the DNA damage response (DDR).…
View article: Preparation and Evaluation of 6-Gingerol Derivatives as Novel Antioxidants and Antiplatelet Agents
Preparation and Evaluation of 6-Gingerol Derivatives as Novel Antioxidants and Antiplatelet Agents Open
Ginger (Zingiber officinale) is widely used as a spice and a traditional medicine. Many bioactivities have been reported for its extracts and the isolated compounds, including cardiovascular protective effects. Different pathways were sugg…
View article: The Impact of Urate‐Lowering Therapy in Post‐Myocardial Infarction Patients: Insights From a Population‐Based, Propensity Score‐Matched Analysis
The Impact of Urate‐Lowering Therapy in Post‐Myocardial Infarction Patients: Insights From a Population‐Based, Propensity Score‐Matched Analysis Open
The role of urate‐lowering therapy (ULT) for the primary prevention of cardiovascular (CV) events has been widely discussed, but its evidence for the secondary prevention of myocardial infarction (MI) is limited. Therefore, we conduct a po…
View article: Adherence to healthy lifestyle improved clinical outcomes in coronary artery disease patients after coronary intervention
Adherence to healthy lifestyle improved clinical outcomes in coronary artery disease patients after coronary intervention Open
Background: Lifestyle modification is suggested for patients with coronary artery disease (CAD), but the impact of adherence to a healthy lifestyle remains undetermined. The aim of this study is to investigate the association of adherence …
View article: Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells
Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells Open
View article: First Total Synthesis of Protoapigenone and Its Analogues as Potent Cytotoxic Agents
First Total Synthesis of Protoapigenone and Its Analogues as Potent Cytotoxic Agents Open
Protoapigenone (1), isolated from Thelypteris torresiana, previously showed significant cytotoxic activity against five human cancer cell lines. In a continued structure-activity relationship study, the first total synthesis and modificati…
View article: Antitumor Agents. 250. † Design and Synthesis of New Curcumin Analogues as Potential Anti-Prostate Cancer Agents
Antitumor Agents. 250. † Design and Synthesis of New Curcumin Analogues as Potential Anti-Prostate Cancer Agents Open
In a continuing study of curcumin analogs as potential drug candidates to treat prostate cancer at both androgen-dependent and androgen-refractory stages, we designed and synthesized over 40 new analogs classified into four series: monophe…
View article: 12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway
12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway Open
Prostratin, a non-tumor promoting 12-deoxyphorbol ester, has been reported as a protein kinase C (PKC) activator and is shown to have anti-proliferative activity in certain cancer cell types. Here we show that GRC-2, a prostratin analogue …
View article: Chemical constituents and anti-platelet aggregation activity from the root of Peucedanum formosanum
Chemical constituents and anti-platelet aggregation activity from the root of Peucedanum formosanum Open
Analysis of the root extract of Peucedanum formosanum (Taiwan Qian-Hu) led to the isolation of 32 known compounds. The structures of these isolates were determined by spectral data. Some of them displayed strong anti-platelet aggregation a…
View article: Identifying New Liver X Receptor Alpha Modulators and Distinguishing Between Agonists and Antagonists By Crystal Ligand Pocket Screening
Identifying New Liver X Receptor Alpha Modulators and Distinguishing Between Agonists and Antagonists By Crystal Ligand Pocket Screening Open
Background: Modulators of LXRα are of high pharmacological interest as LXRα regulates fatty acid metabolism, inflammatory processes and cancer. We aim to identify new LXRα modulators and to recognize a distinguishable feature of ago…
View article: Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery Disease
Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery Disease Open
Polyunsaturated fatty acids (PUFAs) have been suggested for cardiovascular health. This study was conducted to investigate the prognostic impacts of the PUFA metabolites, oxylipins, on clinical outcomes in coronary artery disease (CAD). A …
View article: Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from <i>Epicoccum sorghinum</i>: Toward an Understating of Its Biological Activities and Potential Applications
Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from <i>Epicoccum sorghinum</i>: Toward an Understating of Its Biological Activities and Potential Applications Open
The ethyl acetate extract of an endophyte Epicoccum sorghinum exhibited anti-inflammatory activity at a concentration of 1), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-triol (6), together with six …
View article: Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease
Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease Open
This study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) an…
View article: Age-Dependent Relationship Between Plasma Aβ40 and Aβ42 and Total Tau Levels in Cognitively Normal Subjects
Age-Dependent Relationship Between Plasma Aβ40 and Aβ42 and Total Tau Levels in Cognitively Normal Subjects Open
Both amyloid plaques and neurofibrillary tangles are pathological hallmarks in the brains of patients with Alzheimer's disease (AD). However, the constituents of these hallmarks, amyloid beta (Aβ) 40, Aβ42, and total Tau (t-Tau), have been…
View article: Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish
Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish Open
Safety is one of the most important and critical issues in drug development. Many drugs were abandoned in clinical trials and retracted from the market because of unknown side effects. Cardiotoxicity is one of the most common reasons for d…
View article: Author Correction: The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease
Author Correction: The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease Open
View article: YC-1 Prevents Tumor-Associated Tissue Factor Expression and Procoagulant Activity in Hypoxic Conditions by Inhibiting p38/NF-κB Signaling Pathway
YC-1 Prevents Tumor-Associated Tissue Factor Expression and Procoagulant Activity in Hypoxic Conditions by Inhibiting p38/NF-κB Signaling Pathway Open
Tissue factor (TF) expressed in cancer cells has been linked to tumor-associated thrombosis, a major cause of mortality in malignancy. Hypoxia is a common feature of solid tumors and can upregulate TF. In this study, the effect of YC-1, a …
View article: The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease
The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease Open
View article: Impact of type D personality on clinical outcomes in Asian patients with stable coronary artery disease
Impact of type D personality on clinical outcomes in Asian patients with stable coronary artery disease Open
Type D personality was an independent predictor of CV outcomes in an Asian cohort of stable CAD patients. This personality type may be identified in risk stratification for secondary prevention after PCI.