Yin‐Ching Chan
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View article: Lessons learned from physician-performed high-resolution esophageal manometries
Lessons learned from physician-performed high-resolution esophageal manometries Open
Summary High-resolution esophageal manometry (HRM) is the gold standard test for evaluation and diagnosis of esophageal motility disorders. While the Chicago Classification offers a standardized protocol for performing and interpreting HRM…
View article: Oligo fucoidan alleviates sarcopenia via attenuating muscle mass loss and function decline in senescence-accelerated mouse prone 8 mice
Oligo fucoidan alleviates sarcopenia via attenuating muscle mass loss and function decline in senescence-accelerated mouse prone 8 mice Open
Our findings show that OliFuco is a promising nutritional intervention for mitigating sarcopenia by preserving muscle mass and function in aging populations, offering a novel strategy to address age-related muscle decline.
View article: ETAS®, a Standardized Extract of Asparagus officinalis Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality
ETAS®, a Standardized Extract of Asparagus officinalis Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality Open
Background: ETAS®, a standardized extract of Asparagus officinalis stem, has been found to alleviate cognitive impairment in senescence-accelerated mice prone 8 (SAMP8) and is now considered a functional food in aging. The present study ai…
View article: Oligonol®, an Oligomerized Polyphenol from Litchi chinensis, Enhances Branched-Chain Amino Acid Transportation and Catabolism to Alleviate Sarcopenia
Oligonol®, an Oligomerized Polyphenol from Litchi chinensis, Enhances Branched-Chain Amino Acid Transportation and Catabolism to Alleviate Sarcopenia Open
Branched-chain amino acids (BCAAs) are essential for muscle protein synthesis and are widely acknowledged for mitigating sarcopenia. Oligonol® (Olg), a low-molecular-weight polyphenol from Litchi chinensis, has also been found to attenuate…
View article: Low brain-derived neurotrophic factor and high vascular cell adhesion molecule-1 levels are associated with chronic kidney disease in patients with type 2 diabetes mellitus
Low brain-derived neurotrophic factor and high vascular cell adhesion molecule-1 levels are associated with chronic kidney disease in patients with type 2 diabetes mellitus Open
Background Patients with type 2 diabetes mellitus (DM) have a high prevalence of chronic kidney disease (CKD). Energy imbalance and inflammation may be involved in the pathogenesis of CKD. We examined the effects of brain-derived neurotrop…
View article: Effects of erinacine A-enriched Hericium erinaceus on elderly hearing-impaired patients: A double-blind, randomized, placebo-controlled clinical trial
Effects of erinacine A-enriched Hericium erinaceus on elderly hearing-impaired patients: A double-blind, randomized, placebo-controlled clinical trial Open
We aimed to investigate the effects and mechanisms of Hericium erinaceus (HE) on hearing degeneration. By a double-blind, randomized, clinical trial, all 80 hearing-impaired patients aged 50–79 were randomly divided into the two groups, wh…
View article: Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model
Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model Open
Nonalcoholic fatty liver disease (NAFLD) shows extensive liver cell destruction with lipid accumulation, which is frequently accompanied by metabolic comorbidities and increases mortality. This study aimed to investigate the effects of cof…
View article: Spirulina Prevent Caspase-Independent Apoptosis in the Cochlea and Brainstem of Senescence-Accelerated Prone-8 Mice
Spirulina Prevent Caspase-Independent Apoptosis in the Cochlea and Brainstem of Senescence-Accelerated Prone-8 Mice Open
Background: Spirulina platensis water extract (SP) could decrease hearing degeneration via reducing oxidative stress damages in the auditory system of senescence-accelerated prone-8 (SAMP8) mice. This study aimed to investigate the effects…
View article: Food safety evaluation of papaya fruits resistant to papaya ring spot virus
Food safety evaluation of papaya fruits resistant to papaya ring spot virus Open
Genetically modified (GM) papaya plant resistant to infection by Papaya Ring Spot Virus (PRSV) was successfully generated by cloning the coat protein (CP) gene of the PRSV. However, the food safety of GM foods remains controversial. This s…
View article: A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2
A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2 Open
The prevalence of cognitive impairments and circadian disturbances increases in the elderly and Alzheimer’s disease (AD) patients. This study investigated the effects of a standardized extract of Asparagus officinalis stem, ETAS® on cognit…
View article: Correction: Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice
Correction: Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice Open
[This corrects the article DOI: 10.1371/journal.pone.0178916.].
View article: Effects of Nutritional Intervention on the Survival of Patients with Cardiopulmonary Failure Undergoing Extracorporeal Membrane Oxygenation Therapy
Effects of Nutritional Intervention on the Survival of Patients with Cardiopulmonary Failure Undergoing Extracorporeal Membrane Oxygenation Therapy Open
Early nutritional intervention could benefit patients undergoing ECMO, and those who reached the delivery goal of 80% had significantly better outcomes than other patients. Enteral feeding can begin early and was well tolerated by patients…
View article: Effect of Oligomeric Proanthocyanidin on the Antioxidant Status and Lung Function of Patients with Chronic Obstructive Pulmonary Disease
Effect of Oligomeric Proanthocyanidin on the Antioxidant Status and Lung Function of Patients with Chronic Obstructive Pulmonary Disease Open
OPC supplementation was effective in increasing the antioxidant capacity, in addition to improving the lipid profiles in patients with COPD.
View article: Effects of Spirulina on Expression of N-Methyl D-Aspartate Receptor-2B, Matrix Metalloproteinase-7, and Inflammatory Genes in Chronic Tinnitus
Effects of Spirulina on Expression of N-Methyl D-Aspartate Receptor-2B, Matrix Metalloproteinase-7, and Inflammatory Genes in Chronic Tinnitus Open
Background: The study about chronic tinnitus was seldom reported. We aimed to investigate the effects of Spirulina on the mRNA expressions of N-methyl D-aspartate receptor (NR)-2B, matrix metalloproteinase (MMP)-7, tumor necrosis factor (T…
View article: Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice
Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice Open
[This corrects the article DOI: 10.1371/journal.pone.0178916.].
View article: Complex Coacervation of Soy Proteins, Isoflavones and Chitosan
Complex Coacervation of Soy Proteins, Isoflavones and Chitosan Open
In this study, the chitosan-induced coacervation of soy protein-isoflavone complexes in soymilk was investigated. Most of the soymilk proteins, including β-conglycinin (7S), glycinin (11S), and isoflavones, were found to coacervate into th…
View article: Expressions of ion co-transporter genes in salicylate-induced tinnitus and treatment effects of spirulina
Expressions of ion co-transporter genes in salicylate-induced tinnitus and treatment effects of spirulina Open
Salicylate-induced tinnitus might be associated with increased mRNA expression of KCC2 gene, but not with mRNA expressions of NKCC1 gene in the cochlear and some tinnitus-related brain areas. Spirulina reduced the expression of KCC2 genes …
View article: Effects of tetrandrine and caffeine on cell viability and expression of mammalian target of rapamycin, phosphatase and tensin homolog, histone deacetylase 1, and histone acetyltransferase in glioma cells
Effects of tetrandrine and caffeine on cell viability and expression of mammalian target of rapamycin, phosphatase and tensin homolog, histone deacetylase 1, and histone acetyltransferase in glioma cells Open
Knowledge about the mechanisms underlying the cytotoxicity of tetrandrine and caffeine on glioma cells is limited. The primary objective of this study was to assess the expression of mammalian target of rapamycin (mTOR), phosphatase and te…