Ching Kit Chen
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View article: CTCF Mediates the Cis-Regulatory Hubs in Mouse Hearts
CTCF Mediates the Cis-Regulatory Hubs in Mouse Hearts Open
The 3D chromatin architecture establishes a complex network of genes and regulatory elements necessary for transcriptomic regulation in development and disease. This network can be modeled by cis-regulatory hubs (CRH), which underscore the…
View article: Systematic review and network meta-analysis of outcomes of transcatheter strategies and surgical shunts for treatment of duct-dependent cyanotic congenital heart disease
Systematic review and network meta-analysis of outcomes of transcatheter strategies and surgical shunts for treatment of duct-dependent cyanotic congenital heart disease Open
Introduction Cyanotic congenital heart disease with duct-dependent pulmonary blood flow requires initial palliation before definitive repair. Traditionally, these were surgical systemic-to-pulmonary shunts (SPS) such as the modified Blaloc…
View article: Expert consensus on the burden of respiratory syncytial virus disease and the utility of nirsevimab for disease prevention and protection of infants
Expert consensus on the burden of respiratory syncytial virus disease and the utility of nirsevimab for disease prevention and protection of infants Open
Background Respiratory syncytial virus (RSV) is the most common cause of pediatric acute lower respiratory tract infection worldwide. In Singapore, RSV substantially contributes to the morbidity and mortality of children aged < 5 years, pa…
View article: Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology
Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology Open
Subclinical atherosclerosis underlies most cardiovascular diseases, manifesting before clinical symptoms and representing a key focus for early prevention strategies. Recent advancements highlight the importance of early detection and mana…
View article: Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial
Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial Open
BACKGROUND: Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is an established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared with angiotensin…
View article: The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key
The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key Open
Kawasaki disease (KD) is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels, which commonly occurs in young children. Although self-limiting, there is a risk of developing coronary artery lesi…
View article: The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key
The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key Open
Kawasaki disease is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels which commonly occurs in young children. Although self-limiting, there is a risk of developing coronary artery lesions as…
View article: Regional changes in cellular and molecular pathology in children with end-stage dilated cardiomyopathy: Correlation with regional and global cardiac performance
Regional changes in cellular and molecular pathology in children with end-stage dilated cardiomyopathy: Correlation with regional and global cardiac performance Open
Background Paediatric dilated cardiomyopathy (DCM) carries a poor prognosis. We previously identified regional heterogeneity and patterns of left ventricular (LV) dysfunction that correlated with outcomes. In this project, we aimed to desc…
View article: Analysis of the hospitalization costs of surgical patients with congenital heart disease in the plateau region of western China, 2010–2019
Analysis of the hospitalization costs of surgical patients with congenital heart disease in the plateau region of western China, 2010–2019 Open
The financial burden of patients with CHD in the Chinese western highland region is high. Independent of inflation, CHD hospitalization costs are increasing. Measures taken by medical institutions to control the increase in drug costs, and…
View article: Fetal congenital heart diseases: Diagnosis by anatomical scans, echocardiography and genetic tests
Fetal congenital heart diseases: Diagnosis by anatomical scans, echocardiography and genetic tests Open
Objective: To determine the distribution of major fetal congenital heart diseases (CHDs) diagnosed antenatally during routine second-trimester obstetric anatomical scans in an unselected population at a single tertiary centre and to charac…
View article: Primary prevention of cardiotoxicity in paediatric cancer patients receiving anthracyclines: systematic review and meta-analysis of efficacy and safety profiles
Primary prevention of cardiotoxicity in paediatric cancer patients receiving anthracyclines: systematic review and meta-analysis of efficacy and safety profiles Open
Aims: This review aims to evaluate prospective controlled trials of primary prevention of anthracycline cardiotoxicity in paediatric cancer patients. Methods and Results: Prospective controlled trials in which any cardioprotective agent wa…
View article: CTCF mediates the Activity-by-contact derived cis-regulatory hubs
CTCF mediates the Activity-by-contact derived cis-regulatory hubs Open
The 3D chromatin architecture establishes a complex network of genes and regulatory elements necessary for transcriptomic regulation in development and disease. This network can be modeled by cis-regulatory hubs (CRH) which underscore the …
View article: The Associations Between Preoperative Anthropometry and Postoperative Outcomes in Infants Undergoing Congenital Heart Surgery
The Associations Between Preoperative Anthropometry and Postoperative Outcomes in Infants Undergoing Congenital Heart Surgery Open
Aim: We explored the association between preoperative anthropometry and biochemistry, and postoperative outcomes in infants with CHD after cardiac surgery, as infants with congenital heart disease (CHD) often have feeding difficulties and …
View article: Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort
Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort Open
Background: Variable penetrance and late-onset phenotypes are key challenges for classifying causal as well as incidental findings in inherited cardiac conditions. Allele frequencies of variants in ancestry-specific populations, along with…
View article: 8‐Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin‐Induced Cardiac Dysfunction
8‐Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin‐Induced Cardiac Dysfunction Open
Doxorubicin is an anthracycline widely used for the treatment of various cancers; however, the drug has a common deleterious side effect, namely a dose‐dependent cardiotoxicity. Doxorubicin treatment increases the generation of reactive ox…
View article: The impact of COVID-19 on the practice of pediatric cardiology: a narrative review
The impact of COVID-19 on the practice of pediatric cardiology: a narrative review Open
Background and Objective: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome virus 2 (SARS-CoV-2), is a global pandemic evolving in real time and affecting persons of all ages. Contemporary pediatric data …
View article: Effects of extended pharmacological disruption of zebrafish embryonic heart biomechanical environment on cardiac function, morphology, and gene expression
Effects of extended pharmacological disruption of zebrafish embryonic heart biomechanical environment on cardiac function, morphology, and gene expression Open
Background Biomechanical stimuli are known to be important to cardiac development, but the mechanisms are not fully understood. Here, we pharmacologically disrupted the biomechanical environment of wild‐type zebrafish embryonic hearts for …
View article: The Role of Epigenetics in Congenital Heart Disease
The Role of Epigenetics in Congenital Heart Disease Open
Congenital heart disease (CHD) is the most common birth defect among newborns worldwide and contributes to significant infant morbidity and mortality. Owing to major advances in medical and surgical management, as well as improved prenatal…
View article: Mending a broken heart: <i>In vitro</i>, <i>in vivo</i> and <i>in silico</i> models of congenital heart disease
Mending a broken heart: <i>In vitro</i>, <i>in vivo</i> and <i>in silico</i> models of congenital heart disease Open
Birth defects contribute to ∼0.3% of global infant mortality in the first month of life, and congenital heart disease (CHD) is the most common birth defect among newborns worldwide. Despite the significant impact on human health, most trea…
View article: Cardiotoxicity After Anthracycline Chemotherapy for Childhood Cancer in a Multiethnic Asian Population
Cardiotoxicity After Anthracycline Chemotherapy for Childhood Cancer in a Multiethnic Asian Population Open
Background: Anthracyclines are widely used to treat childhood cancers; however, they cause cardiotoxicity. To address the paucity of clinical data from Asian populations, this study investigated the epidemiology of pediatric anthracycline-…
View article: Changes in Near-Infrared Spectroscopy After Congenital Cyanotic Heart Surgery
Changes in Near-Infrared Spectroscopy After Congenital Cyanotic Heart Surgery Open
CrO2 and SrO2 did not increase after corrective surgery of cyanotic CHD even up to hospital discharge. Future larger studies are required to validate these findings. (This study is registered with ClinicalTrials.gov ID: NCT02417259.).
View article: Diagnostic Dilemma of Constrictive Pericarditis with Concomitant Mitral Stenosis: A Case Report
Diagnostic Dilemma of Constrictive Pericarditis with Concomitant Mitral Stenosis: A Case Report Open
Dear Editor, Constrictive pericarditis (CP) is due to impediment of cardiac diastolic filling secondary to an inelastic and fibrotic pericardium [1]. Observation of this phenomenon is paramount in the understanding of the pathophysiology t…