Ya‐Wen Chang
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View article: A survey of regulatory recommendations for waivers of in vivo bioequivalence studies of generic products for certain dosage forms by participating regulators and organisations of the International Pharmaceutical Regulators Programme. Part 2
A survey of regulatory recommendations for waivers of in vivo bioequivalence studies of generic products for certain dosage forms by participating regulators and organisations of the International Pharmaceutical Regulators Programme. Part 2 Open
A biowaiver generally refers to the request to waive an in vivo bioequivalence study. A biowaiver may be granted not only based on the Biopharmaceutics Classifications System (BCS) but also for many immediate-release dosage forms based on …
View article: Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores
Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores Open
Type 2 diabetes (T2D) poses a significant global health burden. We developed a polygenic risk score (PRS) model based on genome-wide association study (GWAS) findings and integrated it with clinical data to predict T2D risk. This study ana…
View article: Leisure activities, self-reported health, anxiety, and depression in Chinese older adults: a structural equation model analysis
Leisure activities, self-reported health, anxiety, and depression in Chinese older adults: a structural equation model analysis Open
Objectives This study aimed to explore the interrelationships among leisure activities, self-reported health (SRH), anxiety, and depression in Chinese older adults using structural equation modeling (SEM). Methods Data from the 2018 Chines…
View article: Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real‐World Evidence From Regorafenib and Trifluridine/Tipiracil Use
Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real‐World Evidence From Regorafenib and Trifluridine/Tipiracil Use Open
Objective This study aims to evaluate the real‐world effectiveness and safety of sequential treatment with regorafenib and trifluridine/tipiracil (FTD‐TPI) in patients with metastatic colorectal cancer (mCRC) in Taiwan. Methods Data were o…
View article: Tracking Studies on the Effects of Qi Gong Fitness on Stress, Anxiety, and Depression Among Underprivileged Working Youth
Tracking Studies on the Effects of Qi Gong Fitness on Stress, Anxiety, and Depression Among Underprivileged Working Youth Open
The study indicates that Qi Gong fitness had a positive effect on reducing and alleviating stress, anxiety, and depression among young underprivileged professionals. This highlights the potential benefits of incorporating Qi Gong fitness i…
View article: Identification of Genetic Variants for Risk Prediction and Early Diagnosis of Age-Related Macular Degeneration in the Taiwanese Population
Identification of Genetic Variants for Risk Prediction and Early Diagnosis of Age-Related Macular Degeneration in the Taiwanese Population Open
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. The prevalence and phenotypes of AMD differ among populations, including between people in Taiwan and other regions. We performed a genome-w…
View article: <scp>Structure‐based</scp> development of a canine <scp>TNF‐α‐specific</scp> antibody using adalimumab as a template
<span>Structure‐based</span> development of a canine <span>TNF‐α‐specific</span> antibody using adalimumab as a template Open
The canine anti‐tumor necrosis factor‐alpha (TNF‐α) monoclonal antibody is a potential therapeutic option for treating canine arthritis. The current treatments for arthritis in dogs have limitations due to side effects, emphasizing the nee…
View article: Efficacy of a Smartphone Application to Promote Maternal Influenza Vaccination: A Randomized Controlled Trial
Efficacy of a Smartphone Application to Promote Maternal Influenza Vaccination: A Randomized Controlled Trial Open
The maternal vaccine coverage rate has been low in Taiwan. We developed an “Influenza Vaccination Reminder Application” and evaluated its efficacy in improving vaccination intention among pregnant women in Taiwan. A randomized controlled t…
View article: Causal Relationship between Adiponectin and Diabetic Retinopathy: A Mendelian Randomization Study in an Asian Population
Causal Relationship between Adiponectin and Diabetic Retinopathy: A Mendelian Randomization Study in an Asian Population Open
Adiponectin (APN) is suggested to be a potential biomarker for predicting diabetic retinopathy (DR) risk, but the association between APN and DR has been inconsistent in observational studies. We used a Mendelian randomization (MR) analysi…
View article: Neuroprotective Effects of Intraoperative Dexmedetomidine Infusion Combined With Goal-directed Hemodynamic Therapy for Patients Undergoing Cranial Surgery: A Double-blinded Randomized Controlled Trial
Neuroprotective Effects of Intraoperative Dexmedetomidine Infusion Combined With Goal-directed Hemodynamic Therapy for Patients Undergoing Cranial Surgery: A Double-blinded Randomized Controlled Trial Open
BackgroundDespite dexmedetomidine may be neuroprotective in patients undergoing cranial surgery by inhibiting neuroinflammation; however, it reduces cardiac output and cerebral blood flow. We proposed that dexmedetomidine infusion combined…
View article: A synthesized heterocyclic chalcone inhibits neutrophilic inflammation through K <sup>+</sup> ‐dependent pH regulation
A synthesized heterocyclic chalcone inhibits neutrophilic inflammation through K <sup>+</sup> ‐dependent pH regulation Open
Human neutrophils have a vital role in host defense and inflammatory responses in innate immune systems. Growing evidence shows that the overproduction of reactive oxygen species and granular proteolytic enzymes from activated neutrophils …
View article: Effect of adiponectin level and genetic variation of its receptors on diabetic retinopathy
Effect of adiponectin level and genetic variation of its receptors on diabetic retinopathy Open
Adiponectin (APN) and its receptors have been reported to be associated with metabolic phenotypes. To better understand the effects of APN levels and its receptors on diabetic retinopathy (DR), we investigated the association of the plasma…
View article: C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-onset Type 2 Diabetes Mellitus
C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-onset Type 2 Diabetes Mellitus Open
CRP gene variants may contribute to the risk of early-onset T2DM by affecting the serum CRP level.
View article: Urinary Proteomics for the Early Diagnosis of Diabetic Nephropathy in Taiwanese Patients
Urinary Proteomics for the Early Diagnosis of Diabetic Nephropathy in Taiwanese Patients Open
Diabetic nephropathy (DN) is a major complication in diabetic patients. Microalbuminuria testing is used to identify renal disease; however, its predictive value is questionable. We aimed to identify urinary biomarkers to early diagnosis n…
View article: The determining factors of public approval for city cycling path policy in Taiwan
The determining factors of public approval for city cycling path policy in Taiwan Open