Chintan Chheda
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View article: Protein kinase D: A therapeutic target in experimental alcoholic pancreatitis
Protein kinase D: A therapeutic target in experimental alcoholic pancreatitis Open
View article: HDAC4 Mediates Smoking-Induced Pancreatic Cancer Metastasis
HDAC4 Mediates Smoking-Induced Pancreatic Cancer Metastasis Open
Objective Cigarette smoking is an established risk factor for pancreatic ductal adenocarcinoma (PDAC). In this project, we investigated the effect of smoking and the role of histone deacetylase 4 (HDAC4) in PDAC invasion and metastasis. Me…
View article: Co-Variation of Serum Osteoprotegerin and Pigment-Epithelial Derived Factor as Biomarker of Pancreatic Cancer
Co-Variation of Serum Osteoprotegerin and Pigment-Epithelial Derived Factor as Biomarker of Pancreatic Cancer Open
Pancreatic cancer is one the most lethal cancers. Currently, there are reliable predictive markers to assess cancer development. Widely used CA19- 9 molecular marker has been less effective in the diagnosis of early stages of cancer.
View article: Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis
Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis Open
View article: Abstract 2735: Targeting HDAC prevents smoking-induced pancreatic cancer metastasis
Abstract 2735: Targeting HDAC prevents smoking-induced pancreatic cancer metastasis Open
Background: Cigarette smoking is an established risk factor for pancreatic ductal adenocarcinoma (PDAC). Among patients with metastatic PDAC, 90% have liver and 50% have lung metastasis. In this project we investigated the effect of smokin…
View article: Protective effects of urocortin 2 against caerulein-induced acute pancreatitis
Protective effects of urocortin 2 against caerulein-induced acute pancreatitis Open
Because little is known about the role of corticotropin-releasing factor (CRF) agonists in regulating responses in pancreatitis, we evaluated the effects of urocortin 2 (UCN2) and stressin1 in caerulein-induced acute pancreatitis (AP) mode…
View article: Tu1448 – Alcohol-Induced Experimental Pancreatitis: Therapeutic Benefits by Targeting Protein Kinase D
Tu1448 – Alcohol-Induced Experimental Pancreatitis: Therapeutic Benefits by Targeting Protein Kinase D Open
View article: MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC)
MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC) Open
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies and remains difficult to treat. Pancreatic intraepithelial neoplasias (PanINs) represent the majority of the pre-cancer lesions in the pancreas. The PDA…
View article: Novel Small Molecule Inhibitors of Protein Kinase D Suppress NF-kappaB Activation and Attenuate the Severity of Rat Cerulein Pancreatitis
Novel Small Molecule Inhibitors of Protein Kinase D Suppress NF-kappaB Activation and Attenuate the Severity of Rat Cerulein Pancreatitis Open
Nuclear factor-kappa B (NF-κB) activation is a key early signal regulating inflammatory and cell death responses in acute pancreatitis. Our previous in vitro studies with molecular approaches on AR42J cell showed that protein kinase…
View article: Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration
Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration Open
View article: Essential Role of Lyn in Fibrosis
Essential Role of Lyn in Fibrosis Open
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ. The treatment options are inadequate and reflect the fact th…
View article: HDAC3 mediates smoking-induced pancreatic cancer
HDAC3 mediates smoking-induced pancreatic cancer Open
Smoking is a major risk factor for developing pancreatic adenocarcinoma (PDAC); however, little is known about the mechanisms involved. Here we employed a genetic animal model of early stages of PDAC that overexpresses oncogenic Kras in th…
View article: Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis
Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis Open
The results suggest that alcohol has independent effects on promotion of PDAC associated with fibrosis formed through a stellate cell-independent mechanism and that it further promotes early PDAC and M2 macrophage induction in the context …