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View article: Activity-regulated micro-exon splicing programs underlie late-onset plasticity at the axon initial segment
Activity-regulated micro-exon splicing programs underlie late-onset plasticity at the axon initial segment Open
The axon initial segment (AIS) is a specialized neuronal compartment located at the proximal end of axons and initiates action potentials. AIS undergoes plastic changes with aging, disease, and activity levels; however, the molecular mecha…
View article: De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs
De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs Open
View article: De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells
De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells Open
Human pluripotent stem cells (hPSCs) have proven to be valuable tools for both drug discovery and the development of cell-based therapies. However, the long non-coding RNA XIST, which is essential for the establishment and maintenance of X…
View article: Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs
Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs Open
Female human pluripotent stem cells (hPSCs) regularly show erosion of X chromosome inactivation featured by the loss of the long non-coding (lnc) RNA XIST and the accumulation of lncXACT. Here, we report that a common mechanism for the ini…
View article: The De Novo DNA Methyltransferases <i>DNMT3A</i> and <i>DNMT3B</i> Initiate Erosion of Dosage Compensation in Human Pluripotent Stem Cells
The De Novo DNA Methyltransferases <i>DNMT3A</i> and <i>DNMT3B</i> Initiate Erosion of Dosage Compensation in Human Pluripotent Stem Cells Open
View article: Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer
Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer Open
Setanaxib caused mitochondrial ROS accumulation in a hypoxia-selective manner and evoked cancer cell cytotoxicity by inducing apoptosis. Thus, setanaxib has a great potential as a novel anticancer compound under hypoxic conditions.
View article: Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells
Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells Open
View article: Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B
Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B Open
The autophagy-endolysosomal pathway is an evolutionally conserved degradation system that is tightly linked to a wide variety of physiological processes. Dysfunction of this system is associated with many pathological conditions such as ca…
View article: Genetic Ablation of lncRNA <i>XACT</i> Does Not Change Expression Dosage of X-Linked 1 Genes But Impacts Differentiation Potential in Female Human Pluripotent Stem Cells
Genetic Ablation of lncRNA <i>XACT</i> Does Not Change Expression Dosage of X-Linked 1 Genes But Impacts Differentiation Potential in Female Human Pluripotent Stem Cells Open
View article: SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3′ UTR Isoforms in the Nervous System
SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3′ UTR Isoforms in the Nervous System Open
View article: Myocardial lipofuscin accumulation in ageing and sudden cardiac death
Myocardial lipofuscin accumulation in ageing and sudden cardiac death Open
View article: Regeneration-associated cells improve recovery from myocardial infarction through enhanced vasculogenesis, anti-inflammation, and cardiomyogenesis
Regeneration-associated cells improve recovery from myocardial infarction through enhanced vasculogenesis, anti-inflammation, and cardiomyogenesis Open
QQMNCs conferred potent angiogenic and anti-inflammatory properties to the regenerative microenvironment, enhancing myocardiogenesis and functional recovery of rat MI hearts.
View article: Regeneration-Associated Cells Improve Recovery from Myocardial Infarction through Enhanced Vasculogenesis, Anti-inflammation, and Cardiomyogenesis
Regeneration-Associated Cells Improve Recovery from Myocardial Infarction through Enhanced Vasculogenesis, Anti-inflammation, and Cardiomyogenesis Open
Background Considering the impaired function of regenerative cells in patients with comorbidities and associated risk factors, cell therapy to enhance the regenerative microenvironment was designed using regeneration-associated cells (RACs…
View article: Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target
Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target Open
Hepatocellular carcinoma has extremely poor prognosis. In cancerous liver tissues, aberrant proliferation of cancer cells leads to the creation of an area where an immature vascular network is formed. Since oxygen is supplied to cancer tis…
View article: An Adaptation System to Avoid Apoptosis via Autophagy Under Hypoxic Conditions in Pancreatic Cancer Cells
An Adaptation System to Avoid Apoptosis via Autophagy Under Hypoxic Conditions in Pancreatic Cancer Cells Open
The induced autophagy, dependent on the AMPK pathway, is a necessary survival strategy adopted by pancreatic cancer cells to adapt to hypoxic stress, and could be an attractive target for drug development.
View article: Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons
Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons Open
Alternative splicing is crucial for molecular diversification, which greatly contributes to the complexity and specificity of neural functions in the central nervous system (CNS). Neurofascin (NF) is a polymorphic cell surface protein that…