Chitrasen Mohanty
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View article: Comprehensive Insights into Global Mineral Commodities: Analysis, Visualization, and Intelligent Assistance
Comprehensive Insights into Global Mineral Commodities: Analysis, Visualization, and Intelligent Assistance Open
With the growing emphasis on sustainability, criticality, and availability in materials research, providing actionable information about mineral commodities is crucial for informed decision-making and strategic planning by researchers, pol…
View article: CASSIA: a multi-agent large language model for reference free, interpretable, and automated cell annotation of single-cell RNA-sequencing data
CASSIA: a multi-agent large language model for reference free, interpretable, and automated cell annotation of single-cell RNA-sequencing data Open
Cell type annotation is an essential step in single-cell RNA-sequencing analysis, and numerous annotation methods are available. Most require a combination of computational and domain-specific expertise, and they frequently yield inconsist…
View article: Targeted inhibition of BET proteins in HPV16-positive head and neck squamous cell carcinoma reveals heterogeneous transcriptional responses
Targeted inhibition of BET proteins in HPV16-positive head and neck squamous cell carcinoma reveals heterogeneous transcriptional responses Open
Human papillomaviruses (HPV), most commonly HPV16, are associated with a subset of head and neck squamous cell carcinoma (HNSCC) tumors, primarily oropharyngeal carcinomas, with integration of viral genomes into host chromosomes associated…
View article: Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma
Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma Open
View article: Comprehensive Insights into Global Mineral Commodities: Analysis, Visualization and Intelligent Assistance
Comprehensive Insights into Global Mineral Commodities: Analysis, Visualization and Intelligent Assistance Open
With the growing emphasis on sustainability, criticality, and availability in materials research, our study introduces a comprehensive data analytics platform to provide country-specific insights into global elemental production and reserv…
View article: Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure
Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure Open
Stereotactic radiosurgery (SRS) has been shown to be efficacious for the treatment of limited brain metastasis (BM); however, the effects of SRS on human brain metastases have yet to be studied. We performed genomic analysis on resected br…
View article: SpatialView: an interactive web application for visualization of multiple samples in spatial transcriptomics experiments
SpatialView: an interactive web application for visualization of multiple samples in spatial transcriptomics experiments Open
Motivation Spatial transcriptomics (ST) experiments provide spatially localized measurements of genome-wide gene expression allowing for an unprecedented opportunity to investigate cellular heterogeneity and organization within a tissue. S…
View article: Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic susceptibility to childhood-onset asthma
Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic susceptibility to childhood-onset asthma Open
Asthma is a complex disease caused by genetic and environmental factors. Epidemiological studies have shown that in children, wheezing during rhinovirus infection (a cause of the common cold) is associated with asthma development during ch…
View article: CTNI-12. GENOMIC ANALYSIS OF HUMAN BRAIN METASTASES TREATED WITH STEREOTACTIC RADIOSURGERY UNDER THE PHASE-II CLINICAL TRIAL (NCT03398694) REVEALS DNA DAMAGE REPAIR AT THE PERIPHERAL TUMOR EDGE
CTNI-12. GENOMIC ANALYSIS OF HUMAN BRAIN METASTASES TREATED WITH STEREOTACTIC RADIOSURGERY UNDER THE PHASE-II CLINICAL TRIAL (NCT03398694) REVEALS DNA DAMAGE REPAIR AT THE PERIPHERAL TUMOR EDGE Open
Stereotactic Radiosurgery (SRS) is one of the leading treatment modalities for oligo brain metastasis (BM), however no comprehensive genomic data assessing the effect of radiation on BM in humans exist. Leveraging a unique opportunity, as …
View article: Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response
Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response Open
Integrated human papillomavirus (HPV-16) associated head and neck squamous cell carcinoma (HNSCC) tumors have worse survival outcomes compared to episomal HPV-16 HNSCC tumors. Therefore, there is a need to differentiate treatment for HPV-1…
View article: SpatialView: An interactive web application for visualization of multiple samples in spatial transcriptomics experiments
SpatialView: An interactive web application for visualization of multiple samples in spatial transcriptomics experiments Open
Spatial transcriptomics (ST) experiments provide spatially localized measurements of genome-wide gene expression allowing for an unprecedented opportunity to investigate cellular heterogeneity and organization within a tissue. Statistical …
View article: Rhinovirus C causes heterogeneous infection and gene expression in airway epithelial cell subsets
Rhinovirus C causes heterogeneous infection and gene expression in airway epithelial cell subsets Open
View article: SpatialCorr identifies gene sets with spatially varying correlation structure
SpatialCorr identifies gene sets with spatially varying correlation structure Open
Recent advances in spatially resolved transcriptomics technologies enable both the measurement of genome-wide gene expression profiles and their mapping to spatial locations within a tissue. A first step in spatial transcriptomics data ana…
View article: SpatialCorr: Identifying Gene Sets with Spatially Varying Correlation Structure
SpatialCorr: Identifying Gene Sets with Spatially Varying Correlation Structure Open
Recent advances in spatially resolved transcriptomics technologies enable both the measurement of genome-wide gene expression profiles and their mapping to spatial locations within a tissue. A first step in spatial transcriptomics data ana…
View article: Normalization by distributional resampling of high throughput single-cell RNA-sequencing data
Normalization by distributional resampling of high throughput single-cell RNA-sequencing data Open
Motivation Normalization to remove technical or experimental artifacts is critical in the analysis of single-cell RNA-sequencing experiments, even those for which unique molecular identifiers are available. The majority of methods for norm…
View article: Novel immortalized human vocal fold epithelial cell line: In vitro tool for mucosal biology
Novel immortalized human vocal fold epithelial cell line: In vitro tool for mucosal biology Open
Study of vocal fold (VF) mucosal biology requires essential human vocal fold epithelial cell (hVFE) lines for use in appropriate model systems. We steadily transfected a retroviral construct containing human telomerase reverse transcriptas…
View article: Normalization by distributional resampling of high throughput single-cell RNA-sequencing data
Normalization by distributional resampling of high throughput single-cell RNA-sequencing data Open
Motivation Normalization to remove technical or experimental artifacts is critical in the analysis of single-cell RNA-sequencing experiments, even those for which unique molecular identifiers (UMIs) are available. The majority of methods f…