Chixiang Sun
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View article: Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering
Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering Open
The electron transfer from NAD(P)H to heme is a rate‐limiting step in the redox partner‐mediated catalysis of P450 enzyme. However, due to the lack of efficient engineering strategies, it is difficult to improve the properties of redox par…
View article: Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering
Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering Open
The electron transfer from NAD(P)H to heme is a rate‐limiting step in the redox partner‐mediated catalysis of P450 enzyme. However, due to the lack of efficient engineering strategies, it is difficult to improve the properties of redox par…
View article: Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst
Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst Open
Deoxycholic acid (DCA) has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat. The hydroxylated product (6β-OH DCA) was developed to improve the solubility and pharmaceutic properties of DCA for fu…