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View article: Full-view volumetric photoacoustic imaging using a hemispheric transducer array combined with an acoustic reflector
Full-view volumetric photoacoustic imaging using a hemispheric transducer array combined with an acoustic reflector Open
Photoacoustic computed tomography (PACT) has evoked extensive interest for applications in preclinical and clinical research. However, the current systems suffer from the limited view provided by detection setups, thus impeding the suffici…
View article: Time Series Forecasting for Sparse Ring-shaped Array Photoacoustic Imaging Reconstruction
Time Series Forecasting for Sparse Ring-shaped Array Photoacoustic Imaging Reconstruction Open
Photoacoustic computed tomography (PACT), which provides high optical absorption contrast and deep acoustic penetration, plays an important role in non-invasive biomedical imaging area. As the decrease of array elements, the reconstructed …
View article: Photoacoustic imaging with limited sampling: a review of machine learning approaches
Photoacoustic imaging with limited sampling: a review of machine learning approaches Open
Photoacoustic imaging combines high optical absorption contrast and deep acoustic penetration, and can reveal structural, molecular, and functional information about biological tissue non-invasively. Due to practical restrictions, photoaco…
View article: Absolute Grüneisen parameter measurement in deep tissue based on X-ray-induced acoustic computed tomography
Absolute Grüneisen parameter measurement in deep tissue based on X-ray-induced acoustic computed tomography Open
The Grüneisen parameter is a primary parameter of the initial sound pressure signal in the photoacoustic effect, which can provide unique biological information and is related to the temperature change information of an object. The accurat…
View article: Recent Advances in Flexible Ultrasonic Transducers: From Materials Optimization to Imaging Applications
Recent Advances in Flexible Ultrasonic Transducers: From Materials Optimization to Imaging Applications Open
Ultrasonic (US) transducers have been widely used in the field of ultrasonic and photoacoustic imaging system in recent years, to convert acoustic and electrical signals into each other. As the core part of imaging systems, US transducers …
View article: Cantilever-enhanced photoacoustic spectroscopy for gas sensing: A comparison of different displacement detection methods
Cantilever-enhanced photoacoustic spectroscopy for gas sensing: A comparison of different displacement detection methods Open
Photoacoustic spectroscopy (PAS) combines the advantages of high sensitivity, high specificity and zero background, which is very suitable for trace gas detection. Cantilever-enhanced photoacoustic spectroscopy (CEPAS) utilizes highly sens…
View article: Non-Invasive Monitoring of Human Health by Photoacoustic Spectroscopy
Non-Invasive Monitoring of Human Health by Photoacoustic Spectroscopy Open
For certain diseases, the continuous long-term monitoring of the physiological condition is crucial. Therefore, non-invasive monitoring methods have attracted widespread attention in health care. This review aims to discuss the non-invasiv…
View article: Transvaginal fast-scanning optical-resolution photoacoustic endoscopy
Transvaginal fast-scanning optical-resolution photoacoustic endoscopy Open
Photoacoustic endoscopy offers in vivo examination of the visceral tissue using endogenous contrast, but its typical B-scan rate is ∼10 Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present …
View article: In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.
In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra. Open
Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subj…
View article: Dry coupling for whole-body small-animal photoacoustic computed tomography
Dry coupling for whole-body small-animal photoacoustic computed tomography Open
We have enhanced photoacoustic computed tomography with dry acoustic coupling that eliminates water immersion anxiety and wrinkling of the animal and facilitates incorporating complementary modalities and procedures. The dry acoustic coupl…
View article: Time-of-flight compressed-sensing ultrafast photography for encrypted three-dimensional dynamic imaging
Time-of-flight compressed-sensing ultrafast photography for encrypted three-dimensional dynamic imaging Open
We applied compressed ultrafast photography (CUP), a computational imaging technique, to acquire three-dimensional (3D) images. The approach unites image encryption, compression, and acquisition in a single measurement, thereby allowing ef…
View article: Detecting both melanoma depth and volume <i>in vivo</i> with a handheld photoacoustic probe
Detecting both melanoma depth and volume <i>in vivo</i> with a handheld photoacoustic probe Open
We applied a linear-array-based photoacoustic probe to detect the tumor depth and volume of melanin-containing melanoma in nude mice in vivo. We demonstrated the ability of this linear-array-based system to measure both the depth and volum…
View article: Vascular elastic photoacoustic tomography in humans
Vascular elastic photoacoustic tomography in humans Open
Quantification of vascular elasticity can help detect thrombosis and prevent life-threatening conditions such as acute myocardial infarction or stroke. Here, we propose vascular elastic photoacoustic tomography (VE-PAT) to measure vascular…
View article: Photoacoustic elastography
Photoacoustic elastography Open
Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoa…
View article: Towards clinical photoacoustic imaging: developing next-generation endoscopy systems and exploring new contrast agents
Towards clinical photoacoustic imaging: developing next-generation endoscopy systems and exploring new contrast agents Open
Photoacoustic imaging holds great clinical promise because it achieves high-resolution tomographic imaging at depths. Moreover, its strong spectroscopic imaging capability provides a wealth of molecular and functional information based on.…
View article: Photoacoustic tomography of vascular compliance in humans
Photoacoustic tomography of vascular compliance in humans Open
Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed t…
View article: DMD-based spatially Fourier-encoded photoacoustic microscopy
DMD-based spatially Fourier-encoded photoacoustic microscopy Open
We present spatially Fourier-encoded photoacoustic microscopy using a digital micromirror device (DMD). The spatial fluence distribution of laser pulses is Fourier-encoded by the DMD, and a series of such encoded photoacoustic (PA) measure…
View article: Catheter-based photoacoustic endoscope for use in the instrument channel of a clinical video endoscope
Catheter-based photoacoustic endoscope for use in the instrument channel of a clinical video endoscope Open
We have successfully developed a fully-sheathed, flexible shaft-based, mechanical scanning photoacoustic endoscopy (PAE) system for imaging the human gastrointestinal tract via the instrument channel of a clinical video endoscope. The endo…
View article: Optical-resolution photoacoustic endomicroscopy in vivo
Optical-resolution photoacoustic endomicroscopy in vivo Open
Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all tabl…
View article: Handheld photoacoustic probe to detect both melanoma depth and volume at high speed <i>in vivo</i>
Handheld photoacoustic probe to detect both melanoma depth and volume at high speed <i>in vivo</i> Open
We applied a linear‐array‐based photoacoustic probe to detect melanin‐containing melanoma tumor depth and volume in nude mice in vivo . This system can image melanomas at five frames per second (fps), which is much faster than our previous…