Chloé Bourguignon
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View article: Psychological Stress and Venous Thromboembolism: A Narrative Overview
Psychological Stress and Venous Thromboembolism: A Narrative Overview Open
“There is a tendency among young men about hospitals to study the cases, not the patients and, in the interest they take in the disease, lose sight of the individual [...]
View article: Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells
Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells Open
Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development and chronic bronchial diseases. We generated a hiPSC line from a highly characterized healthy heavy smoker male donor free from emphysema or toba…
View article: Thrombosis in the coronary microvasculature may be responsible for impaired cardiac relaxation and diastolic dysfunction
Thrombosis in the coronary microvasculature may be responsible for impaired cardiac relaxation and diastolic dysfunction Open
Introduction Heart Failure with Preserved Ejection Fraction (HFpEF) is proposed to be caused by endothelial dysfunction in cardiac small vessels. We previously identified Hhipl1,as a gene upregulated in the coronary vasculature of Leptin r…
View article: Diastolic dysfunction is associated with cardiac small vessel disease in ovariectomized females but not in males
Diastolic dysfunction is associated with cardiac small vessel disease in ovariectomized females but not in males Open
Introduction Coronary microvascular disease has been proposed to be responsible for heart failure with preserved ejection fraction (HFpEF) about 10 years ago. However, to date the role and phenotype of the coronary microvasculature has sti…
View article: New erythrocyte parameters derived from the Coulter principle relate with red blood cell properties—A pilot study in diabetes mellitus
New erythrocyte parameters derived from the Coulter principle relate with red blood cell properties—A pilot study in diabetes mellitus Open
In routine hematological instruments, blood cells are counted and sized by monitoring the impedance signals induced during their passage through a Coulter orifice. However, only signals associated with centered paths in the aperture are co…
View article: Differentiation of Human Induced Pluripotent Stem Cells from Patients with Severe COPD into Functional Airway Epithelium
Differentiation of Human Induced Pluripotent Stem Cells from Patients with Severe COPD into Functional Airway Epithelium Open
Background: Chronic Obstructive Pulmonary Disease (COPD), a major cause of mortality and disability, is a complex disease with heterogeneous and ill-understood biological mechanisms. Human induced pluripotent stem cells (hiPSCs) are a prom…
View article: The Risk of Thrombosis Around Pregnancy: Where Do We Stand?
The Risk of Thrombosis Around Pregnancy: Where Do We Stand? Open
Pregnancy and puerperium increase the relative risk of venous thromboembolism (VTE) and the absolute risk remains low, around 1 per 1,000, with induced mortality of around 1 per 100,000. Analysis of large databases has helped specify the m…
View article: Pregnancy after Combined Oral Contraceptive-Associated Venous Thromboembolism: An International Retrospective Study of Outcomes
Pregnancy after Combined Oral Contraceptive-Associated Venous Thromboembolism: An International Retrospective Study of Outcomes Open
Background Few data are available on thrombotic outcomes during pregnancy and puerperium occurring after an initial provoked venous thromboembolic (VTE) event. Objectives To describe thrombotic outcomes during pregnancy after a first combi…
View article: Antiphospholipid syndrome in pregnancy: Neuro-psychiatric aspects
Antiphospholipid syndrome in pregnancy: Neuro-psychiatric aspects Open
Nonvascular neurological manifestations of antiphospholipid antibodies (aPLAbs) are emerging and, among these, several neuropsychiatric shymptoms. Psychiatric diseases are gradually being considered as organic illnesses of the brain. The r…
View article: Thrombosis and paroxysmal nocturnal haemoglobinuria
Thrombosis and paroxysmal nocturnal haemoglobinuria Open
Thrombosis is the most common, most feared complication of paroxysmal nocturnal haemoglobinuria (PNH), a striking example of the effect of uncontrolled complement activation and haemolysis on vascular biology and haemostasis. Uncontrolled …
View article: Targeted therapy in eosinophilic chronic obstructive pulmonary disease
Targeted therapy in eosinophilic chronic obstructive pulmonary disease Open
Chronic obstructive pulmonary disease (COPD) is a common and preventable airway disease causing significant worldwide mortality and morbidity. Lifetime exposure to tobacco smoking and environmental particles are the two major risk factors.…
View article: Differentiation of human induced pluripotent stem cells into functional airway epithelium
Differentiation of human induced pluripotent stem cells into functional airway epithelium Open
Rationale Highly reproducible in vitro generation of human bronchial epithelium from pluripotent stem cells is an unmet key goal for drug screening to treat lung diseases. The possibility of using induced pluripotent stem cells (hiPSC) to …
View article: Pipeline for the Generation and Characterization of Transgenic Human Pluripotent Stem Cells Using the CRISPR/Cas9 Technology
Pipeline for the Generation and Characterization of Transgenic Human Pluripotent Stem Cells Using the CRISPR/Cas9 Technology Open
Recent advances in genome engineering based on the CRISPR/Cas9 technology have revolutionized our ability to manipulate genomic DNA. Its use in human pluripotent stem cells (hPSCs) has allowed a wide range of mutant cell lines to be obtain…
View article: Recurrent genetic abnormalities in human pluripotent stem cells: definition and routine detection in culture supernatant by targeted droplet digital PCR
Recurrent genetic abnormalities in human pluripotent stem cells: definition and routine detection in culture supernatant by targeted droplet digital PCR Open
Summary Genomic integrity of human pluripotent stem cells (hPSCs) is essential for research and clinical applications. However, genetic abnormalities can accumulate during hPSC generation and routine culture and following gene editing. The…
View article: La Shigellose : une nouvelle IST ?
La Shigellose : une nouvelle IST ? Open
Objectives: sexual transmitted shigellosis among Men who have Sex with Men (MSM) and emergence of antibiotic resistances is a well-known issue worldwide but has never been described in France. Our first purpose was to confirm the circulati…
View article: Induced Pluripotent Stem Cells for Primary Ciliary Dyskinesia Modeling and Personalized Medicine
Induced Pluripotent Stem Cells for Primary Ciliary Dyskinesia Modeling and Personalized Medicine Open
Primary ciliary dyskinesia (PCD) is a rare and heterogeneous genetic disorder that affects the structure and function of motile cilia. In the airway epithelium, impaired ciliary motion results in reduced or absent mucociliary clearance tha…