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View article: GLUTAMATE DEHYDROGENASE MUTATION REVEALS THE ROLE OF MEDIOBASAL HYPOTHALAMUS IN THE DEVELOPMENT OF SEIZURES
GLUTAMATE DEHYDROGENASE MUTATION REVEALS THE ROLE OF MEDIOBASAL HYPOTHALAMUS IN THE DEVELOPMENT OF SEIZURES Open
View article: The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system Open
Glial cells have emerged as key players in the central control of energy balance and etiology of obesity. Astrocytes play a central role in neural communication via the release of gliotransmitters. Acyl-CoA binding protein (ACBP)-derived e…
View article: Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice
Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice Open
Whereas leptin administration only has a negligible effect on the treatment of obesity, it has been demonstrated that its action can be improved by co-administration of leptin and one of its sensitizers. Considering that oxytocin treatment…
View article: Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing
Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing Open
A hypothalamic alteration of DRP1-induced fission and mROS signaling in response to glucose was observed in HGS-induced IS of rats exposed to a 3 week HFHS diet. Early hypothalamic modifications of the neuronal activity could participate i…
View article: Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection
Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection Open
The hypothalamus have been recognized for decades as one of the major brain centers for the control of energy homeostasis. This area contains specialized neurons able to detect changes in nutrients level. Among them, glucose-sensing neuron…
View article: Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis
Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis Open
The mediobasal hypothalamus (MBH) contains neurons capable of directly detecting metabolic signals such as glucose to control energy homeostasis. Among them, glucose-excited (GE) neurons increase their electrical activity when glucose rise…
View article: Un nouvel acteur dans la détection hypothalamique du glucose : les canaux Transient Receptor Potential Canonical (TRPC)
Un nouvel acteur dans la détection hypothalamique du glucose : les canaux Transient Receptor Potential Canonical (TRPC) Open
Hyperglycemia is detected and integrated by the mediobasal hypothalamus (MBH) which, in turn, inhibits food intake and triggers insulin secretion. The MBH houses specialized glucose-sensitive (GS) neurons, which directly or indirectly modu…
View article: A new actor involved in hypothalamic glucose detection : the Transient Receptor Potential Canonical (TRPC) channels
A new actor involved in hypothalamic glucose detection : the Transient Receptor Potential Canonical (TRPC) channels Open
L’hyperglycémie est détectée et intégrée au niveau de l’hypothalamus médio-basal (MBH) qui inhibe la prise alimentaire et déclenche la sécrétion d’insuline. Le MBH renferme des neurones spécialisés gluco-sensibles (GS) qui détectent direct…