Chloe E. Page
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View article: Natural vs. Surgical Postmenopause and Psychological Symptoms Confound the Effect of Menopause on Executive Functioning Domains of Cognitive Experience
Natural vs. Surgical Postmenopause and Psychological Symptoms Confound the Effect of Menopause on Executive Functioning Domains of Cognitive Experience Open
The type of menopause and psychological symptoms are important confounders of the relationship between the menopause transition and executive dysfunction, and help explain whether executive dysfunction persists or recovers in postmenopause…
View article: Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence
Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence Open
The human amygdala paralaminar nucleus (PL) contains immature excitatory neurons that exhibit protracted maturation into adolescence; however, whether a similar population exists in mice is unknown. We discovered a previously undescribed r…
View article: Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus Open
Adult hippocampal neurogenesis was originally discovered in rodents. Subsequent studies identified the adult neural stem cells and found important links between adult neurogenesis and plasticity, behavior, and disease. However, whether new…
View article: Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice
Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice Open
Reduced activity of the prefrontal cortex (PFC) is seen in mood disorders including depression and anxiety. The mechanisms of this hypofrontality remain unclear. Because of their specific physiological properties, parvalbumin-expressing (P…
View article: Reducing inhibition: A promising new strategy for the treatment of schizophrenia
Reducing inhibition: A promising new strategy for the treatment of schizophrenia Open
Schizophrenia is a complex neuropsychiatric disorder presenting with positive (hallucinations, delusions, psychomotor agitation), negative (flat affect, anhedonia), and cognitive (impaired executive functions) symptoms. Current therapeutic…
View article: Npas4 deficiency interacts with adolescent stress to disrupt prefrontal GABAergic maturation and adult cognitive flexibility
Npas4 deficiency interacts with adolescent stress to disrupt prefrontal GABAergic maturation and adult cognitive flexibility Open
Healthy cognitive and emotional functioning relies on a balance between excitatory and inhibitory neurotransmission in the prefrontal cortex (PFC). This balance is largely established during early postnatal and adolescent developmental per…
View article: Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome
Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome Open
miR-132 and miR-212 are structurally related microRNAs that have been found to exert powerful modulatory effects within the central nervous system (CNS). Notably, these microRNAs are tandomly processed from the same noncoding transcript, a…