Yi Zhang
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View article: Clinical study of PLA2R epitope spreading for predicting proteinuria remission in primary membranous nephropathy
Clinical study of PLA2R epitope spreading for predicting proteinuria remission in primary membranous nephropathy Open
Introduction M-type phospholipase A2 receptor (PLA2R) is the predominant autoantigen in primary membranous nephropathy (PMN), accounting for approximately 70%–80% of cases. Circulating anti-PLA2R IgG is a widely used biomarker to monitor d…
View article: Engineering macrophage phenotype switching via nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome inhibition: A translational approach using antibiotic cement for diabetic foot ulcers
Engineering macrophage phenotype switching via nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome inhibition: A translational approach using antibiotic cement for diabetic foot ulcers Open
Diabetic foot ulcers (DFUs), a debilitating complication of diabetes, are exacerbated by persistent inflammation that disrupts wound repair. This study explores the therapeutic potential of antibiotic‐loaded bone cement (ALBC) in modulatin…
View article: Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution
Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution Open
Obesity and aging are major risk factors for diseases such as Type 2 diabetes mellitus, dementia, and osteoporosis. High‐fat diet (HFD) consumption is one of the most important factors contributing to obesity. To elucidate and provide reso…
View article: Two natural products from the seeds of Citrus reticulata Blanco (Rutaceae) inhibit estrogen biosynthesis by regulating the PI3K-aromatase pathway
Two natural products from the seeds of Citrus reticulata Blanco (Rutaceae) inhibit estrogen biosynthesis by regulating the PI3K-aromatase pathway Open
Introduction The seeds of Citrus reticulata Blanco (Rutaceae) (SCR), a traditional Chinese medicine derived from Citrus, is known for its diverse bioactivities, including potential anti-breast cancer effects, but the mechanism of action re…
View article: Modulation of Lipid Metabolism and Keap1–Nrf2 Pathway Activation in Macrophages by Targeting PPARγ Affects NAFLD Progression
Modulation of Lipid Metabolism and Keap1–Nrf2 Pathway Activation in Macrophages by Targeting PPARγ Affects NAFLD Progression Open
Background and Objectives Lipid metabolism reprogramming regulates cellular inflammatory and immune functions in macrophages. The effects of macrophage‐specific PPARγ on lipid metabolism and oxidative stress remain unclear. This study aime…
View article: Preliminary investigation of nicotinamide N-methyltransferase as an HBV-specific biomarker for hepatocellular carcinoma diagnosis
Preliminary investigation of nicotinamide N-methyltransferase as an HBV-specific biomarker for hepatocellular carcinoma diagnosis Open
Background Nicotinamide N-methyltransferase (NNMT), a metabolic enzyme in the liver, has been implicated in various biological processes, and its high expression in hepatocellular carcinoma has been linked to tumor metastasis and poor prog…
View article: In Vitro Anti-Inflammatory Terpenoid Glycosides from the Seeds of Dolichos lablab
In Vitro Anti-Inflammatory Terpenoid Glycosides from the Seeds of Dolichos lablab Open
To further explore the anti-inflammatory components of the seeds of Dolichos lablab L., a comprehensive phytochemical investigation was conducted using diverse chromatographic and spectrometric technologies, as well as chemical reactions. …
View article: Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial
Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial Open
Introduction: Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could pro…
View article: Research Progress on Exercise Interventions for Physical and Mental Health of Physically Disadvantaged University Students (2008-2024)
Research Progress on Exercise Interventions for Physical and Mental Health of Physically Disadvantaged University Students (2008-2024) Open
View article: Near-Infrared Spectroscopy Combined with Chemometrics for Quantitative Analysis of Anti-Inflammatory Active Ingredients in Relinqing Granule
Near-Infrared Spectroscopy Combined with Chemometrics for Quantitative Analysis of Anti-Inflammatory Active Ingredients in Relinqing Granule Open
View article: Differential metabolic biomarkers between coronary heart disease and diabetes mellitus
Differential metabolic biomarkers between coronary heart disease and diabetes mellitus Open
Background Coronary heart disease (CHD), the leading cause of death globally, is a complex disease often association with metabolic disorders, particularly when co-occurring with diabetes mellitus (DM). However, the mechanisms underlying t…
View article: Development and validation of a clinical prediction model for blastocyst formation during IVF/ICSI-ET
Development and validation of a clinical prediction model for blastocyst formation during IVF/ICSI-ET Open
Purpose This study aims to create and validate a clinical model that predict the probability of blastocyst formation in IVF/ICSI-ET cycles. Methods This study employed a retrospective methodology, gathering data from 4961 cleavage-stage em…
View article: The California collaborative network to promote data driven care and improve outcomes in early psychosis (EPI-CAL) project: rationale, background, design and methodology
The California collaborative network to promote data driven care and improve outcomes in early psychosis (EPI-CAL) project: rationale, background, design and methodology Open
View article: The role of brevican regulation in the antidepressant effects of electroacupuncture in a chronic stress rat model
The role of brevican regulation in the antidepressant effects of electroacupuncture in a chronic stress rat model Open
Objective: To investigate the mechanism of electroacupuncture (EA) for treating depression and to explore the role of brevican in the medial prefrontal cortex (mPFC) in modulating stress susceptibility and the antidepressant effects of EA …
View article: Constituents from Dolichos lablab L. Flowers and Their Anti-Inflammatory Effects via Inhibition of IL-1β Release
Constituents from Dolichos lablab L. Flowers and Their Anti-Inflammatory Effects via Inhibition of IL-1β Release Open
The occurrence of inflammation is closely related to the activation of the NLRP3 inflammasome. IL-1β produced during the activation of the NLRP3 inflammasome has strong pro-inflammatory activity and can also promote the release of inflamma…
View article: Pivotal roles of mitochondria in linking dopamine catabolism to axonal myelination: Implication for the pathogenesis and treatment of schizophrenia
Pivotal roles of mitochondria in linking dopamine catabolism to axonal myelination: Implication for the pathogenesis and treatment of schizophrenia Open
Schizophrenia is one of the most complex and debilitating brain diseases. Patients with schizophrenia may present various clinical manifestations that have been categorized into positive symptoms , negative symptoms, and cognitive deficits…
View article: Efficacy and safety of classical herbal formula Xiao-Yao-San in depression: A systematic review and meta-analysis
Efficacy and safety of classical herbal formula Xiao-Yao-San in depression: A systematic review and meta-analysis Open
Introduction: Xiao-Yao-San (XYS), also Hsiao-Yao-San, a traditional Chinese medicine formula, has been widely demonstrated to relieve depression effectively in clinical trials. However, the results aren’t conclusive. To evaluate the effica…
View article: An analysis of the influencing factors of false negative autoantibodies in patients with non-small cell lung cancer
An analysis of the influencing factors of false negative autoantibodies in patients with non-small cell lung cancer Open
Objectives To analyze the clinical significance of seven autoantibodies (P53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGE, and CAGE) in patients with non-small cell lung cancer (NSCLC) and the factors that influence false-negative results. Methods S…
View article: Predictive value of the domain specific PLA2R antibodies for clinical remission in patients with primary membranous nephropathy: A retrospective study
Predictive value of the domain specific PLA2R antibodies for clinical remission in patients with primary membranous nephropathy: A retrospective study Open
Background M-type phospholipase A2 receptor (PLA2R) is a major auto-antigen of primary membranous nephropathy(PMN). Anti-PLA2R antibody levels are closely associated with disease severity and therapeutic effectiveness. Analysis of PLA2R an…
View article: Mechanisms of Erzhi Pill in Treating Lupus Nephritis Explored by GEO Gene Chips Combined with Network Pharmacology and Molecular Docking
Mechanisms of Erzhi Pill in Treating Lupus Nephritis Explored by GEO Gene Chips Combined with Network Pharmacology and Molecular Docking Open
Background: The study focused on exploring Erzhi Pill's molecular mechanism in treating lupus nephritis (LN) for the first time by means of network pharmacology, combined with molecular docking (MD) and GEO database analysis. Materials and…
View article: Causal role of immune cells in major depressive disorder and bipolar disorder: Mendelian randomization (MR) study
Causal role of immune cells in major depressive disorder and bipolar disorder: Mendelian randomization (MR) study Open
Major depressive disorder (MDD) and bipolar disorder (BD) are prevalent psychiatric conditions linked to inflammatory processes. This study employs a two-sample Mendelian randomization (MR) approach to investigate the relationship between …
View article: The protective effect of fluoxetine on hippocampal oligodendrocytes in AD mice: a potential mechanism involving S100B
The protective effect of fluoxetine on hippocampal oligodendrocytes in AD mice: a potential mechanism involving S100B Open
Fluoxetine (FLX) plays a crucial role in delaying the progression of Alzheimer's disease (AD) and opens up new avenues for investigating the mechanisms of AD. Previous research has shown that FLX has a protective effect on oligodendrocytes…
View article: Apomorphine Sublingual Film Compared with Subcutaneous Apomorphine for OFF Episodes in Parkinson’s Disease: An Open-Label, Randomized, Crossover Study
Apomorphine Sublingual Film Compared with Subcutaneous Apomorphine for OFF Episodes in Parkinson’s Disease: An Open-Label, Randomized, Crossover Study Open
Background: Apomorphine sublingual film (SL-APO) and subcutaneous apomorphine (SC-APO) have been used for the treatment of OFF episodes in Parkinson’s disease (PD). No study has prospectively compared efficacy and safety of these formulati…
View article: Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation
Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation Open
View article: Cerebrospinal fluid biomarkers for the subtle differentiation of neurodegenerative diseases and psychiatric disorders: A systematic review with network meta-analysis
Cerebrospinal fluid biomarkers for the subtle differentiation of neurodegenerative diseases and psychiatric disorders: A systematic review with network meta-analysis Open
Background and purpose Cerebrospinal fluid (CSF) biomarkers are used to identify or detect the condition of multiple neurodegenerative diseases, even psychiatric disorders. However, discordant results between clinical trials failed to meet…
View article: Astragalus injection alters the pharmacokinetics of doxorubicin and affects the activity of CYP450 enzymes
Astragalus injection alters the pharmacokinetics of doxorubicin and affects the activity of CYP450 enzymes Open
Background Doxorubicin (DOX) is an antitumor antibiotic widely used in the treatment of breast cancer, liver cancer, lymphoma and other malignant tumors. However, its clinical application is limited by the side effects and drug resistance.…
View article: Connexin 43: An Interface Connecting Neuroinflammation to Depression
Connexin 43: An Interface Connecting Neuroinflammation to Depression Open
Major depressive disorder (MDD) is a leading chronic mental illness worldwide, characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43), mainly distributed in astrocytes of the brain, is by far the most widely a…
View article: Metamifop as an estrogen-like chemical affects the pituitary-hypothalamic-gonadal (HPG) axis of female rice field eels (Monopterus albus)
Metamifop as an estrogen-like chemical affects the pituitary-hypothalamic-gonadal (HPG) axis of female rice field eels (Monopterus albus) Open
Metamifop (MET) is a widely used herbicide. It is likely for it to enter water environment when utilized, thus potential impacts may be produced on aquatic animals. Little information is available about its effects on the endocrine system …
View article: Effect of <i>Lacticaseibacillus paracasei</i> strain Shirota supplementation on clinical responses and gut microbiome in Parkinson's disease
Effect of <i>Lacticaseibacillus paracasei</i> strain Shirota supplementation on clinical responses and gut microbiome in Parkinson's disease Open
The current randomized, double-blind, placebo-controlled trial showed that Lacticaseibacillus paracasei strain Shirota supplementation improved non-motor symptoms and specific gastrointestinal symptoms in Parkinson's disease patients.
View article: Strategy to Enhance Semicontinuous Anaerobic Digestion of Food Waste Via Exogenous Additives: Experimental and Machine Learning Approaches
Strategy to Enhance Semicontinuous Anaerobic Digestion of Food Waste Via Exogenous Additives: Experimental and Machine Learning Approaches Open