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View article: Cytokine levels in the severity of falciparum malaria: An umbrella review
Cytokine levels in the severity of falciparum malaria: An umbrella review Open
This study aimed to synthesise evidence comparing the levels of cytokines in severe falciparum malaria with those in uncomplicated malaria from available systematic reviews and meta- analyses. Relevant individual meta-analyses were searche…
View article: CagA toxin and risk of Helicobacter pylori-infected gastric phenotype: A meta-analysis of observational studies
CagA toxin and risk of Helicobacter pylori-infected gastric phenotype: A meta-analysis of observational studies Open
Background Helicobacter pylori ( H . pylori) is frequently associated with non-cardia type gastric cancer, and it is designated as a group I carcinogen. This study aimed to systematically review and meta-analyze the evidence on the prevale…
View article: Tamoxifen for adults with hepatocellular carcinoma
Tamoxifen for adults with hepatocellular carcinoma Open
Protocol available via DOI: 10.1002/14651858.CD014869.
View article: Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease: a Chocrane review
Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease: a Chocrane review Open
consultarse para obtener la versión más reciente de la revisión.
View article: Gene therapy for people with hepatocellular carcinoma
Gene therapy for people with hepatocellular carcinoma Open
The evidence is very uncertain about the effects of gene therapy on the studied outcomes because of high risk of bias and imprecision of outcome results. The trials were underpowered and lacked trial data on clinically important outcomes. …
View article: Endoscopic sphincterotomy for adults with biliary sphincter of Oddi dysfunction
Endoscopic sphincterotomy for adults with biliary sphincter of Oddi dysfunction Open
Based on very low-certainty evidence from the trials included in this review, we do not know if endoscopic sphincterotomy versus sham or versus dual endoscopic sphincterotomy increases, reduces, or makes no difference to the number of peop…
View article: Toll-like receptor 9 (-1237 T/C, -1486 T/C) and the risk of gastric cancer: a meta-analysis of genetic association studies
Toll-like receptor 9 (-1237 T/C, -1486 T/C) and the risk of gastric cancer: a meta-analysis of genetic association studies Open
Background Gastric cancer has a complex aetiology including genetic factors. Individual case-control studies of toll like receptor (TLR) 9 (-1237 T/C, -1486 T/C) polymorphisms in the gastric cancer risk were available, and they showed vari…
View article: Prevalence of zoonotic (brugian) filariasis in Asia: A proportional meta-analysis
Prevalence of zoonotic (brugian) filariasis in Asia: A proportional meta-analysis Open
Lymphatic filariasis is a public health problem and targeted for global elimination. WHO recommends mass drug administration to interrupt transmission of the parasites involved. There are concerns that transmission interruption may be diff…
View article: Facilitators and barriers to engaging communities in health service research on dengue control in Indo-Pacific region: a systematic review
Facilitators and barriers to engaging communities in health service research on dengue control in Indo-Pacific region: a systematic review Open
Background Dengue is a public health problem in the Indo-Pacific countries. There are concerns over the facilitators and barriers to community engagement in health service research aimed at dengue control. The objective of his study was to…
View article: Association between IL-10 gene polymorphisms (− 1082 A/G, -819 T/C, -592 A/C) and hepatocellular carcinoma: a meta-analysis and trial sequential analysis
Association between IL-10 gene polymorphisms (− 1082 A/G, -819 T/C, -592 A/C) and hepatocellular carcinoma: a meta-analysis and trial sequential analysis Open
Background The carcinogenesis of hepatocellular carcinoma is complicated, and genetic factor may have the role in the malignant transformation of liver cells. IL-10 gene polymorphisms have been investigated for their potential roles in hep…
View article: The effects of flipped classrooms to improve learning outcomes in undergraduate health professional education: A systematic review
The effects of flipped classrooms to improve learning outcomes in undergraduate health professional education: A systematic review Open
Background The ‘flipped classroom’ approach is an innovative approach in educational delivery systems. In a typical flipped class model, work that is typically done as homework in the didactic model is interactively undertaken in the class…
View article: Community engagement in health services research on soil-transmitted helminthiasis in Asia Pacific region: Systematic review
Community engagement in health services research on soil-transmitted helminthiasis in Asia Pacific region: Systematic review Open
The research question was what studies are available that have assessed community engagement in the health services research on soil-transmitted helminths? We aimed to synthesise evidence on how communities were engaged in health services …
View article: Community engagement in health services research on elimination of lymphatic filariasis: A systematic review
Community engagement in health services research on elimination of lymphatic filariasis: A systematic review Open
This study aimed to contextualize the extent, nature, and quality of community engagement in health services research on eliminating lymphatic filariasis in low-and middle-income countries of Southeast Asia and Pacific Region. We performed…
View article: A comparison of neoadjuvant therapies for gastroesophageal and gastric cancer on tumour resection rate: A network meta-analysis
A comparison of neoadjuvant therapies for gastroesophageal and gastric cancer on tumour resection rate: A network meta-analysis Open
Background Gastric cancer is one of the most common malignancies around the world, and a variety of neoadjuvant chemotherapies with different drug combinations are available for the treatment. R0 resection refers to a microscopically negat…
View article: Sphincterotomy for people with biliary sphincter of Oddi dysfunction
Sphincterotomy for people with biliary sphincter of Oddi dysfunction Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of any type of endoscopic sphincterotomy in people with biliary sphincter of Oddi dysfunction, compared to placebo; sh…
View article: Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease
Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease Open
We identified 11 RCTs (10 double-blind and 1 single-blind) with a total 762 participants. The mean age of participants ranged from 62 to 76 years. Trials were single- or two-centre trials conducted in Iran, New Zealand, Nepal, Turkey, the …
View article: Thymosin-ɑ1 for people with chronic hepatitis B
Thymosin-ɑ1 for people with chronic hepatitis B Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of thymosin‐α1 in people with chronic hepatitis B, regardless of their age, sex, and ethnicity
View article: Prognostic value of mean platelet volume in lung cancer: A meta-analysis
Prognostic value of mean platelet volume in lung cancer: A meta-analysis Open
Review question / Objective: This study aims to synthesize evidence on the role of mean platelet volume in the prognosis of patients with lung cancer using meta-analysis of data from eligible studies.Condition being studied: Lung cancer is…
View article: Toll-like receptor 9 and 4 gene polymorphisms in susceptibility and severity of malaria: a meta-analysis of genetic association studies
Toll-like receptor 9 and 4 gene polymorphisms in susceptibility and severity of malaria: a meta-analysis of genetic association studies Open
Background Malaria is still a major public health problem in sub-Saharan Africa and South-east Asia. The clinical presentations of malaria infection vary from a mild febrile illness to life-threatening severe malaria. Toll like receptors (…
View article: Tamoxifen for hepatocellular carcinoma
Tamoxifen for hepatocellular carcinoma Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of tamoxifen in people with hepatocellular carcinoma, irrespective of sex, administered dose, type of formulation, and…
View article: A meta-analysis of diagnostic test accuracy of Loop-mediated isothermal amplification (LAMP) test in detection of malaria in pregnancy
A meta-analysis of diagnostic test accuracy of Loop-mediated isothermal amplification (LAMP) test in detection of malaria in pregnancy Open
A meta-analysis of diagnostic test accuracy of Loop-mediated isothermal amplification (
View article: WITHDRAWN: Polymorphisms of Tumour necrosis factor-α-308 (rs 1800629) and gastric cancer susceptibility: A meta- analysis of associations studies with trial sequential analysis
WITHDRAWN: Polymorphisms of Tumour necrosis factor-α-308 (rs 1800629) and gastric cancer susceptibility: A meta- analysis of associations studies with trial sequential analysis Open
Background: Gastric cancer is globally the fifth most common cancer. Several studies have assessed the relationship between tumour necrosis factor-alpha (TNF-a- 308) and the risk of gastric cancer. These individual genetic association stud…
View article: The influence of climate factors on COVID-19 transmission in Malaysia: An autoregressive integrated moving average (ARIMA) model
The influence of climate factors on COVID-19 transmission in Malaysia: An autoregressive integrated moving average (ARIMA) model Open
Background A unique concern pertaining to the spread of COVID-19 across countries is the asymmetry of risk and the irrational fear of a new pandemic and its possible serious consequences. This study aimed to perform a time series analysis …
View article: Statins for asthma
Statins for asthma Open
The evidence was of very low certainty, so we are unable to draw conclusions about the effectiveness and safety of statins to treat asthma. High-quality RCTs are needed to assess the effect of statins on people with asthma. Well-designed m…
View article: Multisectoral Approach to Support Use of Insecticide-Treated Net for Malaria Prevention Among Mobile and Migrant Populations in Myanmar: A Systematic Review
Multisectoral Approach to Support Use of Insecticide-Treated Net for Malaria Prevention Among Mobile and Migrant Populations in Myanmar: A Systematic Review Open
Background Myanmar is a premalaria elimination country with artemisinin-resistant malaria. A strategy for transmission control is focused on vulnerable groups such as mobile and migrant populations (MMPs), and includes improving access to …
View article: Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease
Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease in adults.