Cho Hee Kim
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View article: STEM-02. MODULATING INTRACELLULAR RETINOIC ACID METABOLISM TO TARGET GLIOMA STEM CELLS
STEM-02. MODULATING INTRACELLULAR RETINOIC ACID METABOLISM TO TARGET GLIOMA STEM CELLS Open
To elucidate how undifferentiated cancer cells contribute to tumor aggressiveness and treatment failure, we investigated key regulators that preserve the stem-like state in glioblastoma. We identified dehydrogenase/reductase 13 (DHRS13) as…
View article: DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species
DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species Open
To elucidate the complex interplay of undifferentiated cancer cells in malignancy, we focus on the crucial mechanisms that maintain the undifferentiated state of cancer stem-like cells, which drive tumor growth and therapy resistance. Here…
View article: Horse Meat Hydrolysate Ameliorates Dexamethasone-Induced Muscle Atrophy in C57BL/6 Mice via the AKT/FoxO3a/mTOR Pathway
Horse Meat Hydrolysate Ameliorates Dexamethasone-Induced Muscle Atrophy in C57BL/6 Mice via the AKT/FoxO3a/mTOR Pathway Open
As life expectancy increases, muscle atrophy, characterized by a decline in muscle mass and strength that can impair mobility, has become a growing concern, highlighting the potential of protein supplementation as a promising intervention …
View article: A pediatric emergency prediction model using natural language process in the pediatric emergency department
A pediatric emergency prediction model using natural language process in the pediatric emergency department Open
This study developed a predictive model using deep learning (DL) and natural language processing (NLP) to identify emergency cases in pediatric emergency departments. It analyzed 87,759 pediatric cases from a South Korean tertiary hospital…
View article: Hypoxia-Regulated Proteins: Expression in Endometrial Cancer and Their Association with Clinicopathologic Features
Hypoxia-Regulated Proteins: Expression in Endometrial Cancer and Their Association with Clinicopathologic Features Open
Background: Hypoxia-regulated proteins (HIF-1α and GLUT-1) have been identified as prognostic markers in various cancers; however, their role in endometrial cancer remains unclear. This study aimed to evaluate HIF-1α and GLUT-1 expression …
View article: Amendment Proposals for the Act on Decisions on Life-Sustaining Treatment to Improve End-of-Life Care
Amendment Proposals for the Act on Decisions on Life-Sustaining Treatment to Improve End-of-Life Care Open
The Act on Hospice and Palliative Care and Decisions on Life-Sustaining Treatment for Patients at the End of Life (ELDA) was passed by the Korean National Assembly in 2016 and came into effect in 2018. Although the stated purpose of the ac…
View article: The impact of specialized pediatric palliative care on advance care planning and healthcare utilization in children and young adults: a retrospective analysis of medical records of in-hospital deaths
The impact of specialized pediatric palliative care on advance care planning and healthcare utilization in children and young adults: a retrospective analysis of medical records of in-hospital deaths Open
Background Pediatric palliative care supports children and young adults with life-limiting conditions and their families, seeking to minimize suffering and enhance quality of life. This study evaluates the impact of specialized palliative …
View article: FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features
FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features Open
Background: Endometrial cancer (EC) has robust molecular diagnostic evidence that correlates well with prognosis. In various types of cancers, FcRn has been identified as an early marker for prognosis. This study aims to assess FcRn expres…
View article: Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation
Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation Open
Given the clinical success of cytokine blockade in managing diverse inflammatory human conditions, this approach could be exploited for numerous refractory or uncontrolled inflammatory conditions by identifying novel targets for functional…
View article: Factors associated with healthcare utilization for infant falls in South Korea: a cross-sectional online survey
Factors associated with healthcare utilization for infant falls in South Korea: a cross-sectional online survey Open
Purpose: Falls are a common cause of unintentional injuries in infants. This study was conducted to examine the patterns of healthcare utilization following infant falls in South Korea.Methods: This cross-sectional descriptive study utiliz…
View article: Falls and healthcare use in infants under 12 months in South Korea: a cross-sectional online survey
Falls and healthcare use in infants under 12 months in South Korea: a cross-sectional online survey Open
Background:Falls are a common cause of unintentional injury in infants. This study investigated the mechanisms underlying infant falls and healthcare use, measured as hospital visits.Methods:This study used a cross-sectional descriptive de…
View article: Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation
Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation Open
Given the clinical success of cytokine blockade in managing diverse inflammatory human conditions, this approach could be exploited for numerous refractory or uncontrolled inflammatory conditions by identifying novel targets for functional…
View article: An Analysis of John Bowlby’s Mourning Stages in Family Art Therapy as a Way to Help the Family Mourning Process
An Analysis of John Bowlby’s Mourning Stages in Family Art Therapy as a Way to Help the Family Mourning Process Open
This study suggests that art therapy supports bereaved families in alleviating their psychological difficulties, engaging in a healthy mourning process, and functioning as members of society. Further research is needed to better understand…
View article: Supplementary Figure Legends 1-7, Table Legends 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Figure Legends 1-7, Table Legends 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 144K
View article: Supplementary Methods from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Methods from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 152K, File includes Western blotting, RT-PCR, real-time PCR, and nuclear fractionation
View article: Supplementary Tables 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Tables 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 373K, Supplemental Tables S1-S5 include shRNA target sequences (Table S1), primers for RT-PCR, real-time PCR, and ChIP assays (Table S2), regulation of COX subunits and assembly factors (Table S3), Snail binding site in promoter…
View article: Data from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Data from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
Wnt signaling plays a critical role in embryonic development, and its deregulation is closely linked to the occurrence of a number of malignant tumors, including breast and colon cancer. The pathway also induces Snail-dependent epithelial-…
View article: Supplementary Figure Legends 1-7, Table Legends 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Figure Legends 1-7, Table Legends 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 144K
View article: Supplementary Figures 1-7 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Figures 1-7 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 3.8MB, Supplemental Figures S1-S7 include the Induction of EMT in MCF-7 cells (Figure S1), the effects of Wnt on mitochondrial mass (Figure S2), Ponceau S staining corresponding to Figure 4A (Figure S3), ChIP assays using Wnt3a-…
View article: Data from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Data from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
Wnt signaling plays a critical role in embryonic development, and its deregulation is closely linked to the occurrence of a number of malignant tumors, including breast and colon cancer. The pathway also induces Snail-dependent epithelial-…
View article: Supplementary Figures 1-7 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Figures 1-7 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 3.8MB, Supplemental Figures S1-S7 include the Induction of EMT in MCF-7 cells (Figure S1), the effects of Wnt on mitochondrial mass (Figure S2), Ponceau S staining corresponding to Figure 4A (Figure S3), ChIP assays using Wnt3a-…
View article: Supplementary Tables 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Tables 1-5 from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 373K, Supplemental Tables S1-S5 include shRNA target sequences (Table S1), primers for RT-PCR, real-time PCR, and ChIP assays (Table S2), regulation of COX subunits and assembly factors (Table S3), Snail binding site in promoter…
View article: Supplementary Methods from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism
Supplementary Methods from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism Open
PDF file - 152K, File includes Western blotting, RT-PCR, real-time PCR, and nuclear fractionation
View article: A Case of Single-step Mutations at Two Short Tandem Repeat loci (D13S317 and DXS10148) among Three Generations of a Korean Family
A Case of Single-step Mutations at Two Short Tandem Repeat loci (D13S317 and DXS10148) among Three Generations of a Korean Family Open
The DNA profiling of short tandem repeat (STR) markers is a powerful tool for forensic identification and forensic paternity testing.However, STR loci are susceptible to mutation that cause mismatches between parents and children when pate…