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View article: Pinacolborane-assisted superacid organocatalysis enabled direct access to cytotoxic alkyl N-Cbz amines
Pinacolborane-assisted superacid organocatalysis enabled direct access to cytotoxic alkyl N-Cbz amines Open
α-Secondary alkyl amines are structural motifs frequently encountered in a wide variety of natural products and pharmaceuticals. The N-benzyloxycarbonyl (Cbz) compound is a widely used precursor, acknowledged for its efficacy in implementi…
View article: T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines
T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines Open
HVEM-targeting CAR T cells may be useful for the treatment of melanoma.
View article: Triterpenoids from the leaves of Abies koreana and their biological activities
Triterpenoids from the leaves of Abies koreana and their biological activities Open
View article: Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs
Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs Open
Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their ph…
View article: Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom<i>Chlorophyllum molybdites</i>, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom<i>Chlorophyllum molybdites</i>, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities Open
Three isoindolinone alkaloids (1-3), including one new isoindolinone-type alkaloid, meyeroguilline E (1), and six other known compounds (4-9) were isolated from the poisonous mushroom Chlorophyllum mol…
View article: Terpenoids from <i>Glechoma hederacea</i> var. <i>longituba</i> and their biological activities
Terpenoids from <i>Glechoma hederacea</i> var. <i>longituba</i> and their biological activities Open
Glechoma hederacea var. longituba (common name: ground ivy) has been used for the treatment of asthma, bronchitis, cholelithiasis, colds, and inflammation. In the present study, three new sesquiterpene glycosides ( 1 – 3 ), two new diterpe…
View article: Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica
Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica Open
Wasabi (Wasabia japonica (Miq.) Matsum.) is a pungent spice commonly consumed with sushi and sashimi. From the roots of this plant, a new 2-butenolide derivative (1) and 17 previously reported compounds (2–18) were isolated and structurall…
View article: Terpenoids from <i>Glechoma hederacea</i> var. <i>longituba</i> and Their Biological Activities
Terpenoids from <i>Glechoma hederacea</i> var. <i>longituba</i> and Their Biological Activities Open
Glechoma hederacea var. longituba (common name: ground-ivy) has been used for the treatment of asthma, bronchitis, cholelithiasis, colds, and inflammation. In the present study, three new sesquiterpene glycosides ( 1 – 3 ), two new diterpe…
View article: c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer
c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer Open
Chimeric antigen receptor (CAR) technology has been highlighted in recent years as a new therapeutic approach for cancer treatment. Although the impressive efficacy of CAR-based T cell adoptive immunotherapy has been observed in hematologi…
View article: Phenolic Constituents of Chinese Quince Twigs (Chaenomeles sinensis Koehne) and Their Anti-Neuroinflammatory, Neurotrophic, and Cytotoxic Activities
Phenolic Constituents of Chinese Quince Twigs (Chaenomeles sinensis Koehne) and Their Anti-Neuroinflammatory, Neurotrophic, and Cytotoxic Activities Open
Chaenomeles sinensis has been used as a food and traditional medicines. However, most of research on discovering bioactive constituents from this plant have been focused on its yellow fruit, Chinese quince, due to its wide usage. Here, we …
View article: Development of Antigen-specific Chimeric Antigen Receptor KHYG-1 Cells for Glioblastoma
Development of Antigen-specific Chimeric Antigen Receptor KHYG-1 Cells for Glioblastoma Open
Anti-c-Met and anti-AXL CAR NK or T cells could be effective in glioblastoma cells.
View article: Chemical constituents of <i>Chaenomeles sinensis</i> twigs and their biological activity
Chemical constituents of <i>Chaenomeles sinensis</i> twigs and their biological activity Open
A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside ( 1 ), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate …
View article: Identification of Potent CD19 scFv for CAR T Cells through scFv Screening with NK/T-Cell Line
Identification of Potent CD19 scFv for CAR T Cells through scFv Screening with NK/T-Cell Line Open
CD19 is the most promising target for developing chimeric-antigen receptor (CAR) T cells against B-cell leukemic cancer. Currently, two CAR-T-cell products, Kymriah and Yescarta, are approved for leukemia patients, and various anti-CD19 CA…
View article: Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1)
Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1) Open
In this article, we present a novel chemical scaffold that suppresses the activity of an IDH1 mutant.
View article: Three New Oleanane-Type Triterpenoidal Glycosides from Impatiens balsamina and Their Biological Activity
Three New Oleanane-Type Triterpenoidal Glycosides from Impatiens balsamina and Their Biological Activity Open
Three new oleanane-type triterpenoidal glycosides, imbalosides A–C (1–3), were isolated from the white flowers of Impatiens balsamina. The structures of these phytochemical constituents (1–3) were elucidated through 1D and 2D Nuclear Magne…
View article: Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines Open
Myrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh…
View article: Chemical constituents Anti-proliferative activity of resin of C. sphaerocarpa against four human cancer cell lines
Chemical constituents Anti-proliferative activity of resin of C. sphaerocarpa against four human cancer cell lines Open
Myrrh, a resin derived from the Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, stomach pains. In view of this widespread of traditional medicinal use of the m…
View article: Radiosensitizing Effect of Novel Phenylpyrimidine Derivatives on Human Lung Cancer Cells via Cell Cycle Perturbation
Radiosensitizing Effect of Novel Phenylpyrimidine Derivatives on Human Lung Cancer Cells via Cell Cycle Perturbation Open
Radiotherapy is one of the most common treatments for cancer, but radioresistance and injury to normal tissue are considered major obstacles to successful radiotherapy. Thus, there is an urgent need to develop radiosensitizers to improve t…
View article: Antiproliferative Effect of Sterols from Resin of Commiphora habessinica
Antiproliferative Effect of Sterols from Resin of Commiphora habessinica Open
Commiphora habessinica resin is used traditionally to treat various diseases in Ethiopia. In this study the cytotoxic effects of chloroform fraction and cholesterol and lathosterol isolated from the chloroform fraction of the resin of C. h…
View article: Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL
Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL Open
In response to genotoxic stress, the tumor suppressor protein p73 induces apoptosis and cell cycle arrest. Despite extensive studies on p73-mediated apoptosis, little is known about the cytoplasmic apoptotic function of p73. Here, using H1…
View article: Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations
Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations Open
Lespedeza cuneata (Fabaceae), known as Chinese bushclover, has been used in traditional medicines for the treatment of diseases including diabetes, hematuria, and insomnia. As part of a continuing search for bioactive constituents from Kor…
View article: Two New Phenolic Glycosides from <i>Sorbus commixta</i>
Two New Phenolic Glycosides from <i>Sorbus commixta</i> Open
From the stem bark of Sorbus commixta, two new phenolic glycosides, sorcomisides A and B (1 and 2), were isolated along with 10 known compounds. The structures of the isolates were determined by analysis of one-dimensional and two-dimensio…
Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer Open
View article: A New Phenolic Compound from Salix glandulosa
A New Phenolic Compound from Salix glandulosa Open
View article: Holophyllane A: A Triterpenoid Possessing an Unprecedented B-nor-3,4-seco-17,14-friedo-lanostane Architecture from Abies holophylla
Holophyllane A: A Triterpenoid Possessing an Unprecedented B-nor-3,4-seco-17,14-friedo-lanostane Architecture from Abies holophylla Open
A novel triterpenoid, holophyllane A ( 1 ), featuring a B-nor-3,4- seco -17,14- friedo -lanostane, along with its putative precursor, compound 2 were isolated from the methanol extract of the trunks of Abies holophylla . The 2D structure a…
View article: Secoiridoid Glucosides from the Twigs of <i>Syringa oblata</i> var. <i>dilatata</i> and Their Neuroprotective and Cytotoxic Activities
Secoiridoid Glucosides from the Twigs of <i>Syringa oblata</i> var. <i>dilatata</i> and Their Neuroprotective and Cytotoxic Activities Open
Phytochemical investigation of the twigs of Syringa oblata var. diatata led to the isolation of two new secoiridoid glucosides, dilatioside A-B (1-2), along with thirteen known ones (3-15). The structures were determined by spectroscopic m…
View article: Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening Open
View article: Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells
Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells Open
View article: Bioassay-guided Isolation of Antiproliferative Triterpenoids from <i>Euonymus alatus</i> Twigs
Bioassay-guided Isolation of Antiproliferative Triterpenoids from <i>Euonymus alatus</i> Twigs Open
Euonymus alatus (Celastraceae) has been used as an anticancer agent in Korean traditional medicine. However, the potential bioactive contributors to the anticancer effects have not been thoroughly studied. Our screening test revealed that …
View article: A new aliphatic alcohol and cytotoxic chemical constituents from <i>Acorus gramineus</i> rhizomes
A new aliphatic alcohol and cytotoxic chemical constituents from <i>Acorus gramineus</i> rhizomes Open
A new aliphatic alcohol, (2R,6R)-oct-7-ene-2,6-diol (1), and seven other known compounds (2-8) were isolated from Acorus gramineus rhizomes. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including …