Chongchang Zhou
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View article: Impact of ESRRG expression on proliferation and metastasis in laryngeal squamous cell carcinoma
Impact of ESRRG expression on proliferation and metastasis in laryngeal squamous cell carcinoma Open
Background: The estrogen-related receptor gamma ( ESRRG ) gene has been identified as a potential marker for favorable prognosis and a candidate therapeutic target in various cancer types. However, its role in laryngeal squamous cell carci…
View article: Development and validation of an immune-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization
Development and validation of an immune-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization Open
The IRG-related signature has been developed to predict survival results and immunological features of HNSCC. The model's robustness across various clinical subgroups, coupled with its capacity to predict responses to immunotherapy, highli…
View article: Machine learning-based identification of exosome-related biomarkers and drugs prediction in nasopharyngeal carcinoma
Machine learning-based identification of exosome-related biomarkers and drugs prediction in nasopharyngeal carcinoma Open
This study identifies five exosome-related key genes, utilizing machine learning approaches to develop a diagnostic model and uncover potential drug targets for NPC. These findings offer novel perspectives for both the diagnosis and therap…
View article: ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases
ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases Open
Anoctamin 1 (ANO1), also known as TMEM16A, is a multifunctional protein that serves as a calcium-activated chloride channel (CaCC). It is ubiquitously expressed across various tissues, including epithelial cells, smooth muscle cells, and n…
View article: Identification of a telomere-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization
Identification of a telomere-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization Open
Telomere-related genes (TRGs) are vital in diverse tumor types. Nevertheless, there is a notable lack of in-depth research concerning their significance in head and neck squamous cell carcinoma (HNSCC). In this context, the present study a…
View article: Identification of a disulfidptosis-related lncRNA signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma
Identification of a disulfidptosis-related lncRNA signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma Open
Purpose Disulfidptosis, a newly identified form of cell death, is triggered by disulfide stress. Herein, a unique signature was developed based on disulfidptosis-related lncRNAs (DRlncRNAs) for the prognostic and immune landscape predictio…
View article: SLC20A1 is a prospective prognostic and therapy response predictive biomarker in head and neck squamous cell carcinoma
SLC20A1 is a prospective prognostic and therapy response predictive biomarker in head and neck squamous cell carcinoma Open
SLC20A1 overexpression in HNSCC, characterized by increased cellular invasion, migration and proliferation, is a potential prognostic biomarker and therapeutic response indicator.
View article: Development of Chromatin Regulator-related Molecular Subtypes and aSignature to Predict Prognosis and Immunotherapeutic Response in Headand Neck Squamous Cell Carcinoma
Development of Chromatin Regulator-related Molecular Subtypes and aSignature to Predict Prognosis and Immunotherapeutic Response in Headand Neck Squamous Cell Carcinoma Open
Background: Chromatin regulators (CRs) serve as indispensable factors in tumor biological processes by influencing tumorigenesis and the immune microenvironment and have been identified in head and neck squamous cell carcinoma (HNSCC). Hen…
View article: Pancancer analysis reveals the role of disulfidptosis in predicting prognosis, immune infiltration and immunotherapy response in tumors
Pancancer analysis reveals the role of disulfidptosis in predicting prognosis, immune infiltration and immunotherapy response in tumors Open
Disulfidptosis has been reported as a novel cell death process, suggesting a therapeutic strategy for cancer treatment. Herein, we constructed a multiomics data analysis to reveal the effects of disulfidptosis in tumors. Data for 33 kinds …
View article: Identification and validation of a novel signature based on T cell marker genes to predict prognosis, immunotherapy response and chemotherapy sensitivity in head and neck squamous carcinoma by integrated analysis of single-cell and bulk RNA-sequencing
Identification and validation of a novel signature based on T cell marker genes to predict prognosis, immunotherapy response and chemotherapy sensitivity in head and neck squamous carcinoma by integrated analysis of single-cell and bulk RNA-sequencing Open
T cells are among the most potent anti-tumor cells that are found in humans. Our study sought to develop a reliable signature incorporating T cell marker genes (TMGs) for predicting the prognosis and therapy responsiveness of head and neck…
View article: Tumor-associated macrophages-related gene signature for prediction of prognosis and immunotherapy response in head and neck squamous carcinomas
Tumor-associated macrophages-related gene signature for prediction of prognosis and immunotherapy response in head and neck squamous carcinomas Open
Purpose The immune cells that infiltrate the tumor microenvironment most frequently are tumor-associated macrophages (TAMs). Increasing evidence has shown the positive correlation of TAMs with poor outcomes in human cancers. Yet, only a sm…
View article: Identification of a new anoikis-related gene signature for prognostic significance in head and neck squamous carcinomas
Identification of a new anoikis-related gene signature for prognostic significance in head and neck squamous carcinomas Open
Anoikis, a mode of programmed cell death, is essential for normal development and homeostasis in the organism and plays an important role in the onset and progression of cancers. The authors of this research sought to establish a gene sign…
View article: 5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma
5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma Open
Background 5-Methylcytosine (m 5 C) methylation is recognized as an mRNA modification that participates in biological progression by regulating related lncRNAs. In this research, we explored the relationship between m 5 C-related lncRNAs (…
View article: Additional file 2 of 5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma
Additional file 2 of 5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma Open
Additional file 2: Table S1. Results for ceRNA in tumor based on LncSEA database.
View article: High eukaryotic initiation factor <scp>5A2</scp> expression predicts poor prognosis and may participate in the <scp>SNHG16</scp>/<scp>miR</scp>‐10b‐5p/<scp>EIF5A2</scp> regulatory axis in head and neck squamous cell carcinoma
High eukaryotic initiation factor <span>5A2</span> expression predicts poor prognosis and may participate in the <span>SNHG16</span>/<span>miR</span>‐10b‐5p/<span>EIF5A2</span> regulatory axis in head and neck squamous cell carcinoma Open
Background This study attempted to investigate the significance of eukaryotic initiation factor 5A2 (EIF5A2) in the prognosis and regulatory network of head and neck squamous cell carcinoma (HNSCC). Methods EIF5A2 expression, prognostic in…
View article: Identification of a cuproptosis-related lncRNA signature to predict the prognosis and immune landscape of head and neck squamous cell carcinoma
Identification of a cuproptosis-related lncRNA signature to predict the prognosis and immune landscape of head and neck squamous cell carcinoma Open
Background Cuproptosis is considered a novel copper-induced cell death model regulated by targeting lipoylated TCA cycle proteins. In this study, we established a novel signature based on cuproptosis-related lncRNAs (crlncRNAs) to predict …
View article: Identification of cuproptosis‐related subtypes and characterization of the tumor microenvironment landscape in head and neck squamous cell carcinoma
Identification of cuproptosis‐related subtypes and characterization of the tumor microenvironment landscape in head and neck squamous cell carcinoma Open
Background Cuproptosis is considered a novel copper‐dependent cell death model. In this study, we established a novel scoring system based on 10 cuproptosis‐related genes (CRGs) to predict the prognosis and immune landscape of head and nec…
View article: <i>Arylsulfatase I</i> is a prognostic biomarker for head and neck squamous cell carcinoma and Pan‐cancer
<i>Arylsulfatase I</i> is a prognostic biomarker for head and neck squamous cell carcinoma and Pan‐cancer Open
Background Sulfatase gene family members mediate various biological functions in tumor stroma and tumor cell environments. However, the expressions and prognostic value of Arylsulfatase I ( ARSI ), a sulfatase gene family member, in head a…
View article: Identification of several senescence‐associated genes signature in head and neck squamous cell carcinoma
Identification of several senescence‐associated genes signature in head and neck squamous cell carcinoma Open
Background As one of the core aging processes, cellular senescence is associated with tumorigenesis, growth, and immune modulation in cancers. Nevertheless, the prognosis of senescence‐associated genes (SAGs) signature in head and neck squ…
View article: A 5’-tiRNA fragment that inhibits proliferation and migration of laryngeal squamous cell carcinoma by targeting PIK3CD
A 5’-tiRNA fragment that inhibits proliferation and migration of laryngeal squamous cell carcinoma by targeting PIK3CD Open
tRNA-derived small RNAs (tsRNAs) participate in several biological processes, including carcinogenesis. The correlations between tsRNAs and human cancers are attracting substantial attention. Nevertheless, the involvement of tsRNAs in lary…
View article: A novel Pyroptosis‐related long non‐coding<scp>RNA</scp>signature for predicting the prognosis and immune landscape of head and neck squamous cell carcinoma
A novel Pyroptosis‐related long non‐coding<span>RNA</span>signature for predicting the prognosis and immune landscape of head and neck squamous cell carcinoma Open
Background Pyroptosis plays an essential function in carcinogenesis and the antitumor immune response. Herein, we constructed a pyroptosis‐related long noncoding RNA (prLncRNA) signature to predict therapeutic effects and outcomes for head…
View article: Identification of immune‐related lncRNA panel for predicting immune checkpoint blockade and prognosis in head and neck squamous cell carcinoma
Identification of immune‐related lncRNA panel for predicting immune checkpoint blockade and prognosis in head and neck squamous cell carcinoma Open
Purpose Immunotherapy is changing head and neck squamous cell carcinoma (HNSCC) treatment pattern. According to the Chinese Society of Clinical Oncology (CSCO) guidelines, immunotherapy has been deemed as first‐line recommendation for recu…
View article: Construction of a necroptosis‐related lncRNA signature to predict the prognosis and immune microenvironment of head and neck squamous cell carcinoma
Construction of a necroptosis‐related lncRNA signature to predict the prognosis and immune microenvironment of head and neck squamous cell carcinoma Open
Background Previous studies have determined that necroptosis‐related genes are potential biomarkers in head and neck squamous cell carcinoma (HNSCC). Herein, we established a novel risk model based on necroptosis‐related lncRNAs (nrlncRNAs…
View article: <i>CD3D</i>: a prognostic biomarker associated with immune infiltration and immunotherapeutic response in head and neck squamous cell carcinoma
<i>CD3D</i>: a prognostic biomarker associated with immune infiltration and immunotherapeutic response in head and neck squamous cell carcinoma Open
Recent studies have demonstrated that CD3D activates T-cell-related signal transduction and is associated with the antitumor immune response in several cancers. This study explored the role of CD3D in head and neck squamous cell carcinoma …
View article: Construction of an algorithm based on oncosis‐related LncRNAs comprising the molecular subtypes and a risk assessment model in lung adenocarcinoma
Construction of an algorithm based on oncosis‐related LncRNAs comprising the molecular subtypes and a risk assessment model in lung adenocarcinoma Open
Background As an important non‐apoptotic cell death method, oncosis has been reported to be closely associated with tumors in recent years. However, few research reported the relationship between oncosis and lung cancer. Methods In this st…
View article: Construction of an Algorithm Based on Oncosis-Related LncRNAs Comprising the Molecular Subtypes and a Risk Assessment Model in Lung Adenocarcinoma
Construction of an Algorithm Based on Oncosis-Related LncRNAs Comprising the Molecular Subtypes and a Risk Assessment Model in Lung Adenocarcinoma Open
As an important non-apoptotic cell death method, oncosis has been reported to be closely associated with tumors in recent years. However, few researches have reported the relationship between oncosis and lung cancer. In this study, we esta…
View article: Pyroptosis patterns and immune infiltrates characterization in head and neck squamous cell carcinoma
Pyroptosis patterns and immune infiltrates characterization in head and neck squamous cell carcinoma Open
Background Pyroptosis plays an essential role in tumor immune responses and inflammation related to chemotherapy. Herein, we studied the characteristic patterns of pyroptosis in head and neck squamous cell carcinoma (HNSCC) to determine th…