Explanipedia

Targeting immune microenvironment in cervical cancer: current research and advances Open

Zhen Zhang, Miao Liu, Yu An, Chongqing Gao, Tao Wang , et al. · 2025

Aurora B facilitates cholangiocarcinoma progression by stabilizing <span>c‐Myc</span> Open

Ke Liu, Xuxuan Zhou, Fei Huang, Lihao Liu, Zijian Xu , et al. · 2024

Background Cholangiocarcinoma (CCA), a malignancy that arises from biliary epithelial cells, has a dismal prognosis, and few targeted therapies are available. Aurora B, a key mitotic regulator, has been reported to be involved in the progr…

A DNA/RNA heteroduplex oligonucleotide coupling asparagine depletion restricts FGFR2 fusion-driven intrahepatic cholangiocarcinoma Open

Zhenzhen Chu, Baohuan Zhang, Xuxuan Zhou, Hui Yuan, Chongqing Gao , et al. · 2023

Pemigatinib, a pan-FGFR inhibitor, is approved to treat intrahepatic cholangiocarcinoma (ICC) harboring FGFR2 fusion mutations. Improving its targeting of FGFR2 fusions remains an unmet clinical need due to its pan selectivity and resistan…

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin Open

Chongqing Gao, Zhen-Zhen Chu, Di Zhang, Yang Xiao, Xing-Yan Zhou , et al. · 2023

Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis Open

Yang You, Chongqing Gao, Junru Wu, Hengdong Qu, Yang Xiao , et al. · 2022

AMPK-related protein kinase 5 (ARK5) is involved in a broad spectrum of physiological and cell events, and aberrant expression of ARK5 has been observed in a wide variety of solid tumors, including liver cancer. However, the role of ARK5 i…

Periplaneta americana extract alleviates steatohepatitis in a mouse model by modulating HMGB1-mediated inflammatory response Open

Yang Xiao, Chongqing Gao, Junru Wu, Jing Li, Lijuan Wang , et al. · 2022

Alcoholic abuse and obesity are the most common lifestyle implications of chronic liver injury, and always act synergistically to increase the risk of mortality. Periplaneta americana has a long history of being applied in medicine, includ…

NUSAP1, a novel stemness‐related protein, promotes early recurrence of hepatocellular carcinoma Open

Jinying Li, Ming Tang, Junru Wu, Hengdong Qu, Mengxian Tu , et al. · 2022

Early recurrence (within 2 years after resection) is the primary cause of poor outcomes among hepatocellular carcinoma (HCC) patients, and liver cancer stem cells are the main contributors to postsurgical HCC recurrence. Nucleolar and spin…

Serine/threonine kinase TBK1 promotes Intrahepatic cholangiocarcinoma progression via direct regulation of β-catenin Open

Chongqing Gao, Zhenzhen Chu, Xiao Yang, Xingyan Zhou, Junru Wu , et al. · 2022

Intrahepatic Cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy with limited therapeutic options. Metastasis is one of the main contributors to ICC progression and poor prognosis. However, the underlying mechanism of ICC …

Serine/threonine kinase TBK1 promotes Intrahepatic cholangiocarcinoma progression via direct regulation of β-catenin Open

Chongqing Gao, Zhen-Zhen Chu, Yang Xiao, Xing-Yan Zhou, Junru Wu , et al. · 2022

Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy with limited therapeutic options. Metastasis is one of the main contributors to ICC progression and poor prognosis. However, the underlying mechanism of ICC …

Downregulation of Circular RNA circPSD3 Promotes Metastasis by Modulating FBXW7 Expression in Clear Cell Renal Cell Carcinoma Open

Xuexia Xie, Haomin Li, Chongqing Gao, Yiqi Lai, Junjie Liang , et al. · 2022

Circular RNAs (circRNAs), a novel class of noncoding RNAs, have been shown to play critical regulatory roles in clear cell renal cell carcinoma (ccRCC). Metastasis is the main contributor to the poor prognosis of patients with ccRCC. Howev…

Surgical outcomes and survival for T4 gastric cancer extending to the transverse colon Open

Gangcheng Wang, Yingjun Liu, Chongqing Gao, Youcai Wang, Huifang Lv , et al. · 2020

Patients with T4 gastric cancer extending to the transverse colon might benefit from curative resection with acceptable morbidity and mortality.

Surgical outcomes and survival for T4 gastric cancer extending to the transverse colon Open

Gangcheng Wang, Chongqing Gao, You-cai Wang, Huifang Lv, Beibei Chen , et al. · 2020

Purpose Extended multi-organ resection for locally advanced (T4) gastric cancer remains controversial. Herein we aimed to evaluate the surgical outcomes and survival of patients with T4 gastric cancer extending to the transverse colon. Mat…

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