Chongyu Tian
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View article: Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus
Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus Open
The global outbreak of monkeypox virus (MPXV), combined with the termination of smallpox vaccination and the lack of specific antiviral treatments, raises increasing concerns. The surface proteins M1R and B6R of MPXV are crucial for virus …
View article: An mRNA vaccine against monkeypox virus inhibits infection by co-activation of humoral and cellular immune responses
An mRNA vaccine against monkeypox virus inhibits infection by co-activation of humoral and cellular immune responses Open
The persistent monkeypox outbreaks intensify the demand for monkeypox vaccines. Based on the mRNA vaccine platform, we conduct a systematic screening of monkeypox virus (MPXV) surface proteins from two types of viral particles, extracellul…
View article: Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens
Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens Open
The vaccine developed in this study provides complete protection against divergent H5N1 AIV strains in chickens, offering a promising approach for the future development of mRNA vaccines against multivalent avian influenza subtypes.
View article: Lung-Selective Delivery of mRNA-Encoding Anti-MERS-CoV Nanobody Exhibits Neutralizing Activity Both In Vitro and In Vivo
Lung-Selective Delivery of mRNA-Encoding Anti-MERS-CoV Nanobody Exhibits Neutralizing Activity Both In Vitro and In Vivo Open
Background/Objectives: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a highly pathogenic virus causing severe respiratory illness, with limited treatment options that are mostly supportive. The success of mRNA technology i…
View article: A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection
A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection Open
View article: Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes
Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes Open
Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections in infants and children. Currently, no approved HMPV vaccine is available. We developed a novel recombinant influenza virus, which carried partial HMPV F…
View article: Purified immunoglobulin F(ab')2 could protect mice and rhesus monkeys from lethal ricin intoxication
Purified immunoglobulin F(ab')2 could protect mice and rhesus monkeys from lethal ricin intoxication Open
Objective: Ricin is a highly toxic ribosome-inactivation lectin derived from castor beans. So far, there has been no antidote to treat ricin-poisoned patients, and the development of a safe and effective antidote is urgently needed.
View article: Preparation of equine immunoglobulin F(ab′)2 against smallpox and evaluation of its immunoprotective effect
Preparation of equine immunoglobulin F(ab′)2 against smallpox and evaluation of its immunoprotective effect Open
Objective: Smallpox is a severe infectious disease caused by the smallpox virus, and the death rate is as high as 30% within 15–20 days post infection.
View article: Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes
Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes Open
Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections in infants and children. Currently, no approved HMPV vaccine is available. We developed a novel recombinant influenza virus, which carried partial HMPV F…
View article: Preparation of Equine Immunoglobulin F(ab′)2 against Smallpox and Evaluation of its Immunoprotective Effect
Preparation of Equine Immunoglobulin F(ab′)2 against Smallpox and Evaluation of its Immunoprotective Effect Open
Objective: Smallpox, a severe infectious disease caused by the smallpox virus, causes a death rate as high as 30% within 15-20 days after infection. Therefore, development of anti-Smallpox product as a strategic reserve is urgently needed.…
View article: Purified Immunoglobulin F(ab′)2 Protects Mice and Rhesus Monkeys against Lethal Ricin Intoxication
Purified Immunoglobulin F(ab′)2 Protects Mice and Rhesus Monkeys against Lethal Ricin Intoxication Open
Objective: Ricin is a highly toxic ribosome-inactivating lectin derived from castor beans. To date, no antidote is available to treat ricin-poisoned patients, and the development of a safe and effective antidote is urgently needed. Methods…
View article: NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection
NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection Open
(1) Background: With the resurgence of brucellosis epidemics in China in recent years, the chances of a brucella coinfection with other common respiratory pathogens, such as the influenza virus, have increased dramatically. However, little…
View article: Development and efficacy evaluation of a SP01-adjuvanted inactivated Escherichia coli mutant vaccine against bovine coliform mastitis
Development and efficacy evaluation of a SP01-adjuvanted inactivated Escherichia coli mutant vaccine against bovine coliform mastitis Open
Objective: Escherichia coli (E. coli) is one of the most common pathogens causing clinical mastitis in cattle, and there is no available vaccine to prevent this disease in China; therefore, there is an urgent need to develop an E. coli vac…
View article: Development and Efficacy Evaluation of an SP01-adjuvanted Inactivated Escherichia Coli Mutant Vaccine Against Bovine Coliform Mastitis
Development and Efficacy Evaluation of an SP01-adjuvanted Inactivated Escherichia Coli Mutant Vaccine Against Bovine Coliform Mastitis Open
Objective: Escherichia coli ( E. coli ) is one of the most common pathogens causing clinical mastitis in cattle, but no vaccine is available to prevent this disease in China. Therefore, development of an E. coli vaccine against bovine clin…
View article: Construction and Evaluation of the Brucella Double Gene Knock-out Vaccine Strain MB6 Δbp26ΔwboA (RM6)
Construction and Evaluation of the Brucella Double Gene Knock-out Vaccine Strain MB6 Δbp26ΔwboA (RM6) Open
Objective: Brucellosis is a serious zoonotic infection worldwide. To date, vaccination is the most effective measure against brucellosis. This study was aimed at obtaining a vaccine strain that has high protective efficacy and low toxicity…