Choon Han Heh
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View article: Comparative Molecular Dynamics Reveals How LRRK2 Inhibitors Distinguish G2019S from Wild-Type
Comparative Molecular Dynamics Reveals How LRRK2 Inhibitors Distinguish G2019S from Wild-Type Open
Leucine-rich repeat kinase 2 (LRRK2) has become a critical drug target in Parkinson’s disease, with mutation-selective inhibitors offering promising potential for precision medicine. However, the structural similarity between G2019S and wi…
View article: An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms
An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms Open
Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming. However, existing elapid antivenoms are known for their lo…
View article: Hit-to-Lead Short Peptides against Dengue Type 2 Envelope Protein: Computational and Experimental Investigations
Hit-to-Lead Short Peptides against Dengue Type 2 Envelope Protein: Computational and Experimental Investigations Open
Data from the World Health Organisation show that the global incidence of dengue infection has risen drastically, with an estimated 400 million cases of dengue infection occurring annually. Despite this worrying trend, there is still no th…
View article: Development of MTH1-Binding Nucleotide Analogs Based on 7,8-Dihalogenated 7-Deaza-dG Derivatives
Development of MTH1-Binding Nucleotide Analogs Based on 7,8-Dihalogenated 7-Deaza-dG Derivatives Open
MTH1 is an enzyme that hydrolyzes 8-oxo-dGTP, which is an oxidatively damaged nucleobase, into 8-oxo-dGMP in nucleotide pools to prevent its mis-incorporation into genomic DNA. Selective and potent MTH1-binding molecules have potential as …
View article: Docking, synthesis and bioassay studies of imine derivatives as potential inhibitors for dengue NS2B/ NS3 serine protease
Docking, synthesis and bioassay studies of imine derivatives as potential inhibitors for dengue NS2B/ NS3 serine protease Open
Objective: To search imine derivatives as new active agents against dengue type 2 NS2B/NS3 using molecular docking, since there is no effective vaccine against flaviviral infections.Methods: In this research, molecular docking was performe…
View article: Phosphodiesterase-5 inhibitors and their analogues as adulterants of herbal and food products: analysis of the Malaysian market, 2014–16
Phosphodiesterase-5 inhibitors and their analogues as adulterants of herbal and food products: analysis of the Malaysian market, 2014–16 Open
Adulteration of herbal health supplements with phosphodiesterase-5 (PDE-5) inhibitors and their analogues is becoming a worldwide problem. The aim of this study was to investigate herbal and food products sold in the Malaysian market for t…
View article: Prevalence of c.2268dup and detection of two novel alterations, c.670_672del and c.1186C>T, in the<i>TPO</i>gene in a cohort of Malaysian–Chinese with thyroid dyshormonogenesis
Prevalence of c.2268dup and detection of two novel alterations, c.670_672del and c.1186C>T, in the<i>TPO</i>gene in a cohort of Malaysian–Chinese with thyroid dyshormonogenesis Open
Objectives The c.2268dup mutation in the thyroid peroxidase ( TPO ) gene is the most common TPO alteration reported in Taiwanese patients with thyroid dyshormonogenesis. The ancestors of these patients are believed to originate from the so…