Chris Arnatt
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View article: Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex
Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex Open
The mitochondrial pyruvate carrier (MPC) plays a role in numerous diseases including neurodegeneration, metabolically dependent cancers, and the development of insulin resistance. Several previous studies in genetic mouse models or with ex…
View article: Fluorescent human RPA to track assembly dynamics on DNA
Fluorescent human RPA to track assembly dynamics on DNA Open
View article: Fluorescent human RPA to track assembly dynamics on DNA
Fluorescent human RPA to track assembly dynamics on DNA Open
DNA metabolic processes including replication, repair, recombination, and telomere maintenance occur on single-stranded DNA (ssDNA). In each of these complex processes, dozens of proteins function together on the ssDNA template. However, w…