Christopher B. Little
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View article: Reducing the burden of osteoarthritis in Australia: A 2024–2025 research priority-setting study
Reducing the burden of osteoarthritis in Australia: A 2024–2025 research priority-setting study Open
We determined key research priorities for OA. These can help guide research directions and funding to enhance outcomes for people with OA.
The Impact of the Ovine Annular Lesion Model on <span>IVD</span> Pathobiology and Utility of the Ovine Spinal Model in Patho‐Anatomical Studies: A Historical Perspective Open
This review documents the impact of the Osti ovine annular lesion model of intervertebral disc (IVD) degeneration on the elucidation of degenerative changes in the ovine IVD also seen in human IVD degeneration (IVDD). The degenerative path…
The utility of animal models in understanding osteoarthritis (OA) pathogenesis – an update on the impact of genetically modified mice Open
Osteoarthritis (OA) is one of the most common health conditions worldwide leading to immense individual and societal burden. Current treatments for OA are inadequate with no approved structural disease modifying therapies, and existing opt…
View article: Structural Variations of Tendons: A Systematic Search and Narrative Review of Histological Differences Between Tendons, Tendon Regions, Sex, and Age
Structural Variations of Tendons: A Systematic Search and Narrative Review of Histological Differences Between Tendons, Tendon Regions, Sex, and Age Open
Tendons are force‐transmitting structures which facilitate musculoskeletal functioning. Characterizing variations between different anatomical tendons, regions within tendons, as well as between the sexes and with age can improve understan…
View article: Tendon biomechanical properties are altered by storage duration but not freeze‐thaw temperatures or cycles
Tendon biomechanical properties are altered by storage duration but not freeze‐thaw temperatures or cycles Open
Tendon allograft and xenograft processing often involves one or more steps of freezing and thawing. As failure strength is an important graft consideration, this study aimed to evaluate effects on failure properties when varying freeze‐tha…
Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis Open
Background Synovial pathology has been linked to osteoarthritis (OA) pain in patients. Microscopic grading systems for synovial changes in human OA have been described, but a standardized approach for murine models of OA is needed. We soug…
View article: Streamlining quantitative joint-wide medial femoro-tibial histopathological scoring of mouse post-traumatic knee osteoarthritis models
Streamlining quantitative joint-wide medial femoro-tibial histopathological scoring of mouse post-traumatic knee osteoarthritis models Open
A single mid-sagittal slide reduced the time needed to score diverse histopathological changes by 87% without compromising the sensitivity or specificity of the analysis, across a variety of ptOA models and time-points.
Disease-modifying interactions between chronic kidney disease and osteoarthritis: a new comorbid mouse model Open
Objective The prevalence of comorbid chronic kidney disease (CKD) and osteoarthritis (OA) is increasing globally. While sharing common risk factors, the mechanism and consequences of concurrent CKD-OA are unclear. The aims of the study wer…
Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an in vitro co-culture model Open
Osteoarthritis (OA) is a leading cause of chronic pain and disability, for which there is no cure. Mesenchymal stromal cells (MSCs) have been used in clinical trials for treating OA due to their unique ability to generate paracrine anti-in…
View article: Dataset 1 for: "The biomechanical, biochemical and morphological properties of nineteen human cadaveric lower limb tendons and ligaments: an open access dataset."
Dataset 1 for: "The biomechanical, biochemical and morphological properties of nineteen human cadaveric lower limb tendons and ligaments: an open access dataset." Open
Dataset 1: This dataset provides the morphological, biomechanical and biochemical properties of human tendons and ligaments of the lower limb. It is the first instalment in the creation of a larger comprehensive dataset of a wide range of …
Loss of <i>Grem1</i> -articular cartilage progenitor cells causes osteoarthritis Open
SUMMARY Osteoarthritis (OA), which carries an enormous disease burden across the world, is characterised by irreversible degeneration of articular cartilage (AC), and subsequently bone. The cellular cause of OA is unknown. Here, using line…
View article: Challenging the Perceptions of Human Tendon Allografts: Influence of Donor Age, Sex, Height, and Tendon on Biomechanical Properties
Challenging the Perceptions of Human Tendon Allografts: Influence of Donor Age, Sex, Height, and Tendon on Biomechanical Properties Open
Background: The use of allograft tendons has increased for primary and revision anterior cruciate ligament reconstruction, but allograft supply is currently limited to a narrow range of tendons and donors up to the age of 65 years. Expandi…
View article: In Vitro Collagenase Degradation of Grafts Used Clinically for Anterior Cruciate Ligament Reconstruction: Human Tendon Data
In Vitro Collagenase Degradation of Grafts Used Clinically for Anterior Cruciate Ligament Reconstruction: Human Tendon Data Open
Increasing anterior cruciate ligament (ACL) rupture rates are driving the need for new graft materials which undergo testing to characterize material properties and function. The in vitro collagenase assay is routinely used to determine th…
Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an <i>in vitro</i> co-culture model Open
Osteoarthritis (OA) is a leading cause of chronic pain and disability, for which there is no cure. Mesenchymal stromal cells (MSCs) have been used in clinical trials for treating OA due to their unique functions to send paracrine anti-infl…
View article: Animal models of osteoarthritis
Animal models of osteoarthritis Open
Cite this article: Bone Joint Res 2022;11(8):514–517.
The Immunological Effect of Oxygen Carriers on Normothermic Ex Vivo Liver Perfusion Open
Introduction Normothermic ex vivo liver perfusion (NEVLP) is an organ preservation method that allows liver graft functional assessment prior to transplantation. One key component of normothermic perfusion solution is an oxygen carrier to …
Orthobiologics in orthopedic applications: a report from the TMI Havemeyer meeting on orthobiologics Open
Readily available and effective therapeutic approaches are increasingly required to overcome the growing demand for optimized management of musculoskeletal degenerative conditions. The use of biologic therapies has been gaining ground in t…
In vitro ascorbic acid sensitivity_FigShare_2022.xlsx Open
In vitro ascorbic acid senstivity of Macrophomina phaseolina isolates.
Soybean cut-stem assay Open
Influence of ascorbic acid treatment on Macrophomina phaseolina lesion lesion development in a cut-stem assay.
An Interdisciplinary Perspective on Greenland’s Changing Coastal Margins Open
Greenland’s coastal margins are influenced by the confluence of Arctic and Atlantic waters, sea ice, icebergs, and meltwater from the ice sheet. Hundreds of spectacular glacial fjords cut through the coastline and support thriving marine e…
Consensus for Statements Regarding a Definition for Spinal Osteoarthritis for Use in Research and Clinical Practice: A Delphi Study Open
Objective To determine consensus among an international, multidisciplinary group of experts regarding definitions of spinal osteoarthritis for research and for clinical practice. Methods A 15‐member, multidisciplinary steering committee ge…