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View article: MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens
MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens Open
Methylthioadenosine phosphorylase ( MTAP ) gene deletions are frequent in human cancers. Loss of MTAP leads to significantly increased cellular levels of methylthioadenosine (MTA), a cellular metabolite and specific inhibitor of the cell-e…
View article: Response of Atlantic salmon to long-term sustained aerobic training at suboptimum elevated temperature: Cardiac anatomy, aerobic performance, and growth implications
Response of Atlantic salmon to long-term sustained aerobic training at suboptimum elevated temperature: Cardiac anatomy, aerobic performance, and growth implications Open
Sustained aerobic training is suggested to enhance cardiac performance and growth in farmed salmonids, but its effects under suboptimum elevated temperatures remain unclear. This study examined whether continuous training at different temp…
View article: The Nutritional Aspects of Cannibalism in Crustacean Aquaculture: With Emphasis on Cultured Tropical Spiny Lobsters
The Nutritional Aspects of Cannibalism in Crustacean Aquaculture: With Emphasis on Cultured Tropical Spiny Lobsters Open
Cannibalism in high‐value crustacean species, such as mud crab, clawed lobster, and spiny lobster, is a major impediment to commercial aquaculture due to its significant impact on survival and, hence, production. Knowledge of the nutrition…
View article: Geometric stoichiometry model yields relevant insights for assessing nutrient-related environmental impacts of aquaculture
Geometric stoichiometry model yields relevant insights for assessing nutrient-related environmental impacts of aquaculture Open
Aquaculture plays a crucial role in global food security and is being increasingly used to aid species and ecosystem conservation. However, concerns over environmental impact of aquaculture expansion are driving research into ecosystem app…
View article: Dietary Protein Affects the Growth Response and Tissue Composition of Juvenile Slipper Lobster (Thenus australiensis)
Dietary Protein Affects the Growth Response and Tissue Composition of Juvenile Slipper Lobster (Thenus australiensis) Open
The effect of different dietary protein levels on apparent feed intake, apparent digestibility, body composition, nutrient retention, and growth efficiency of juvenile slipper lobster (Thenus australiensis) were evaluated for 74 days. Thre…
View article: Increasing primary care capacity by adding team members
Increasing primary care capacity by adding team members Open
CONTEXT: Over 6.5 million adults in Canada do not have a family doctor or nurse practitioner. Interprofessional team-based care can expand access to primary care, however, the relationship between interprofessional teams and their impact o…
View article: Transcriptomic and nutritional analysis of the hepatopancreas in cultured juvenile Panulirus ornatus throughout the moult cycle
Transcriptomic and nutritional analysis of the hepatopancreas in cultured juvenile Panulirus ornatus throughout the moult cycle Open
Juveniles of the ornate spiny lobster, Panulirus ornatus, grow rapidly through frequent moulting events, requiring them to accumulate sufficient nutrient reserves to fuel the energetically demanding process of ecdysis. As moulting events o…
View article: Functional morphology and ontogeny of mouthparts and mouth aperture of Panulirus ornatus and Sagmariasus verreauxi: Implications towards formulated feeds development
Functional morphology and ontogeny of mouthparts and mouth aperture of Panulirus ornatus and Sagmariasus verreauxi: Implications towards formulated feeds development Open
Development of formulated feed is now a focal point in advancing the aquaculture of spiny lobster species. This study investigated the functional morphology of two spiny lobsters, Panulirus ornatus and Sagmariasus verreauxi, by analysing m…
View article: Changes in the physiology and chitin metabolism in cultured juvenile Panulirus ornatus across the moult cycle
Changes in the physiology and chitin metabolism in cultured juvenile Panulirus ornatus across the moult cycle Open
Crustaceans undergo periodic moulting events to facilitate growth, this is a physiological and energetically demanding process. In an aquaculture environment, crustaceans are generally cultured in a defined space and often at high densitie…
View article: The problems with pin bones: Intermuscular bone development and function in salmonids and their implications for aquaculture
The problems with pin bones: Intermuscular bone development and function in salmonids and their implications for aquaculture Open
A healthy skeletal system is fundamental to fish welfare and performance and a key physiological feature of a robust fish. The presence of skeletal deformities in farmed salmonids is a persistent welfare problem in aquaculture, and one whi…
View article: Graduate instructors navigating the AI frontier: The role of ChatGPT in higher education
Graduate instructors navigating the AI frontier: The role of ChatGPT in higher education Open
This research study explores the use of artificial intelligence (AI) in undergraduate assessments, specifically focusing on the ability of graduate teaching assistants (GTAs) to identify AI-generated assessments and the performance of Chat…
View article: The mismatch between swimming speeds and flow regimes when optimising exercise regimes to improve Chinook salmon, Oncorhynchus tshawytscha, performance
The mismatch between swimming speeds and flow regimes when optimising exercise regimes to improve Chinook salmon, Oncorhynchus tshawytscha, performance Open
Exercise regimes provide a promising opportunity to enhance production performance during hatchery rearing, but exercise-enhanced traits are presently poorly understood in Chinook salmon. In addition, spinal health can be a concern in some…
View article: Effects of Bacillus subtilis as a single strain probiotic on growth, disease resistance and immune response of striped catfish (Pangasius hypophthalmus)
Effects of Bacillus subtilis as a single strain probiotic on growth, disease resistance and immune response of striped catfish (Pangasius hypophthalmus) Open
The present study investigated the potential role of Bacillus subtilis as probiotic in striped catfish ( Pangasius hypophthalmus ). Fish (initial weight = 150.00±2.63g n = 180) were stocked in circular tanks. Four isonitrogenous (30%) and …
View article: Real-world outcomes from a series of patients with late onset Pompe disease who switched from alglucosidase alfa to avalglucosidase alfa
Real-world outcomes from a series of patients with late onset Pompe disease who switched from alglucosidase alfa to avalglucosidase alfa Open
Introduction: Pompe disease is an inherited, progressive neuromuscular disorder caused by deficiency of lysosomal acid α-glucosidase and accumulation of glycogen in tissues, resulting in cellular dysfunction, muscle damage, and functional …
View article: Dietary replacement of soybean meal with black soldier fly larvae meal in juvenile Labeo rohita and Catla catla: Effects on growth, nutritional quality, oxidative stress biomarkers and disease resistance
Dietary replacement of soybean meal with black soldier fly larvae meal in juvenile Labeo rohita and Catla catla: Effects on growth, nutritional quality, oxidative stress biomarkers and disease resistance Open
This experiment aimed to investigate the effects of partial substitution of crude protein from soybean meal (SBM) with black soldier fly ( Hermetia illucens ) larvae meal (BSFLM) in juvenile rohu ( Labeo rohita ) and catla ( Catla catla ).…
View article: Effect of Feed Texture and Dimensions, on Feed Waste Type and Feeding Efficiency in Juvenile Sagmariasus verreauxi
Effect of Feed Texture and Dimensions, on Feed Waste Type and Feeding Efficiency in Juvenile Sagmariasus verreauxi Open
The “messy” feeding behaviour of spiny lobsters remains an obstacle for formulated feed development. This study examined the relationship between feeding efficiency and feed waste by juvenile spiny lobster, Sagmariasus verreauxi, fed diffe…
View article: Application of a stoichiometric bioenergetic approach and whole-body protein synthesis to the nutritional assessment of juvenile Thenus australiensis
Application of a stoichiometric bioenergetic approach and whole-body protein synthesis to the nutritional assessment of juvenile Thenus australiensis Open
The present study successfully combined a stoichiometric bioenergetic approach with an endpoint stochastic model to simultaneously determine specific dynamic action, metabolic substrate use and whole-body protein synthesis in juvenile slip…