Chris D. Turnbull
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View article: Lack of awareness prevents the use of compost and biochar as soil amendments by Ghanaian cocoa farmers
Lack of awareness prevents the use of compost and biochar as soil amendments by Ghanaian cocoa farmers Open
Organic amendments can be used to reduce the environmental impact of cocoa farming, increase sustainability, and protect livelihoods. This study aimed to explore Ghanaian cocoa farmers' awareness and usage of compost and biochar on their f…
View article: Impact of GLP-1 receptor agonist-induced weight loss on 22 cancers in the next ten years using a Markov state-transition model – A UK weight and wellness cancer landscape analysis
Impact of GLP-1 receptor agonist-induced weight loss on 22 cancers in the next ten years using a Markov state-transition model – A UK weight and wellness cancer landscape analysis Open
Targeted weight control measures using GLP-1RAs could reduce new cancer cases. Based on our models, the potential risk of thyroid cancer is balanced by a reduction in other cancer types. This modelling study shows for the first time that i…
View article: The “TASK” of Breathing: Anesthetic Relevance of Background Two-Pore Domain Potassium Channels as Therapeutic Targets for Respiratory Control
The “TASK” of Breathing: Anesthetic Relevance of Background Two-Pore Domain Potassium Channels as Therapeutic Targets for Respiratory Control Open
Background (leak) potassium (K+) currents, the main contributors to resting membrane potential in excitable cells, are mediated by channels of the 2-pore domain (K2P) family. In the respiratory system, the TWIK-related acid-sensitive K+ ch…
View article: The effect of supplemental oxygen and continuous positive airway pressure withdrawal on endocan levels
The effect of supplemental oxygen and continuous positive airway pressure withdrawal on endocan levels Open
View article: Nocturnal oxygen therapy in obstructive sleep apnoea: a systematic review and meta-analysis
Nocturnal oxygen therapy in obstructive sleep apnoea: a systematic review and meta-analysis Open
Obstructive sleep apnoea is characterised by recurrent reduction of airflow during sleep leading to intermittent hypoxia. Continuous positive airway pressure is the first-line treatment but is limited by poor adherence. Nocturnal oxygen th…
View article: Mild obstructive sleep apnoea in females:<i>post hoc</i>analysis of the MERGE randomised controlled trial
Mild obstructive sleep apnoea in females:<i>post hoc</i>analysis of the MERGE randomised controlled trial Open
Background A post hoc analysis of the MERGE trial was conducted, to investigate whether sex differences are evident at the mildest end of the disease spectrum, for symptoms associated with obstructive sleep apnoea (OSA) and the response to…
View article: Impact of GLP Agonist Induced Weight Loss on 22 Cancers in the Next Ten Years Using a Markov State Transition Model - A UK Weight and Wellness Cancer Landscape Analysis
Impact of GLP Agonist Induced Weight Loss on 22 Cancers in the Next Ten Years Using a Markov State Transition Model - A UK Weight and Wellness Cancer Landscape Analysis Open
View article: Efficacy of vibrotactile positional therapy devices on patients with positional obstructive sleep apnoea: a systematic review and meta-analysis
Efficacy of vibrotactile positional therapy devices on patients with positional obstructive sleep apnoea: a systematic review and meta-analysis Open
Introduction Vibrotactile positional therapy (PT) devices are a new treatment modality for positional obstructive sleep apnoea (POSA). This review aimed to determine the effect of vibrotactile PT on the Apnoea Hypopnoea Index (AHI) and the…
View article: Seeking Precision
Seeking Precision Open
View article: Right ventricular responses to CPAP therapy in obstructive sleep apnea: CMR analysis of the MOSAIC randomized trial
Right ventricular responses to CPAP therapy in obstructive sleep apnea: CMR analysis of the MOSAIC randomized trial Open
Effects of continuous positive airway pressure (CPAP) on right ventricular (RV) function in patients with untreated mild‐to‐moderate obstructive sleep apnea (OSA) are unclear. In this exploratory analysis of cardiac magnetic resonance (CMR…
View article: Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence, Severity, and Treatment Response
Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence, Severity, and Treatment Response Open
Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, sever…
View article: THE ADDITIVE EFFECT OF AWAKE PRONE POSITIONING ON OXYGEN REQUIREMENTS AND SATURATIONS IN PATIENTS WITH COVID-19 ESTABLISHED ON CPAP
THE ADDITIVE EFFECT OF AWAKE PRONE POSITIONING ON OXYGEN REQUIREMENTS AND SATURATIONS IN PATIENTS WITH COVID-19 ESTABLISHED ON CPAP Open
View article: 0788 The effect of CPAP on quality of life in females with mild OSA: Post hoc analysis from the MERGE Randomised Trial
0788 The effect of CPAP on quality of life in females with mild OSA: Post hoc analysis from the MERGE Randomised Trial Open
Introduction The MERGE trial was a multi-centre, randomised, parallel study that showed the beneficial effect of continuous positive airway pressure (CPAP) on quality-of-life in patients with mild obstructive sleep apnea (OSA) (Wimms et al…
View article: Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial
Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial Open
View article: Improved COVID-19 outcomes in a large non-invasive respiratory support cohort despite emergence of the alpha variant
Improved COVID-19 outcomes in a large non-invasive respiratory support cohort despite emergence of the alpha variant Open
Introduction Respiratory high-dependency units (rHDUs) are used to manage respiratory failure in COVID-19 outside of the intensive care unit (ICU). The alpha variant of COVID-19 has been linked to increased rates of mortality and admission…
View article: BAY 2253651 for the treatment of obstructive sleep apnoea: a multicentre, double-blind, randomised controlled trial (SANDMAN)
BAY 2253651 for the treatment of obstructive sleep apnoea: a multicentre, double-blind, randomised controlled trial (SANDMAN) Open
BAY 2253651 is a nasally applied genioglossus muscle activator via pharyngeal mucosal receptor stimulation (potassium channel blocker) aimed to treat obstructive sleep apnoea. Although well-tolerated and safe, there was no significant ther…
View article: Smoothing Out the Peaks and Valleys of High-Altitude Sleep Apnea
Smoothing Out the Peaks and Valleys of High-Altitude Sleep Apnea Open
View article: Period-to-Period Variability of Moderate/Severe Obstructive Sleep Apnoea
Period-to-Period Variability of Moderate/Severe Obstructive Sleep Apnoea Open
View article: The Noninvasive Ventilation Outcomes (NIVO) score: prediction of in-hospital mortality in exacerbations of COPD requiring assisted ventilation
The Noninvasive Ventilation Outcomes (NIVO) score: prediction of in-hospital mortality in exacerbations of COPD requiring assisted ventilation Open
Introduction Acute exacerbations of COPD (AECOPD) complicated by acute (acidaemic) hypercapnic respiratory failure (AHRF) requiring ventilation are common. When applied appropriately, ventilation substantially reduces mortality. Despite th…
View article: A challenging case of hypercapnic respiratory failure during pregnancy
A challenging case of hypercapnic respiratory failure during pregnancy Open
We describe a 40-year-old female who presented with progressive breathlessness and hypercapnic respiratory failure during pregnancy secondary to undiagnosed muscle-specific kinase myasthenia gravis. Her presentation was progressive and pro…
View article: Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience
Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience Open
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospec…
View article: Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial Open
The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Car…
View article: COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study
COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study Open
View article: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study
COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study Open
View article: The NIVO Score: Admission and 90-Day Mortality Following Acute Non-Invasive Ventilation (NIV) for Exacerbations of COPD
The NIVO Score: Admission and 90-Day Mortality Following Acute Non-Invasive Ventilation (NIV) for Exacerbations of COPD Open
View article: Editorial on paper: The prevalence of sleep-disordered breathing in Northwest Russia – A problem worth knowing about?
Editorial on paper: The prevalence of sleep-disordered breathing in Northwest Russia – A problem worth knowing about? Open
View article: Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial
Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial Open
View article: Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea
Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea Open
View article: A simple ex vivo model of human renal allograft preservation using the gonadal vein
A simple ex vivo model of human renal allograft preservation using the gonadal vein Open
Introduction Hypothermic machine perfusion, an organ preservation modality, involves flow of chilled preservation fluid through an allograft’s vasculature. This study describes a simple, reproducible, human model that allows for interrogat…
View article: Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology
Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology Open
The 2018 European Respiratory Society (ERS) International Congress held in Paris, France, served as a platform to discover the latest research on respiratory diseases, the improvement in their treatments and patient care. Specifically, the…