Clare K. Fitzpatrick
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View article: A descriptive analysis of rural seniors with femur and pelvis fractures and the impact of morphine milliequivalents on inpatient rehabilitation
A descriptive analysis of rural seniors with femur and pelvis fractures and the impact of morphine milliequivalents on inpatient rehabilitation Open
A BSTRACT Background: The US population ≥65 years old is rapidly growing. Geriatric disorders including hip fractures are becoming more numerous and the medical cost is significant. Hip fractures increase the risk of mortality in geriatric…
View article: Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain
Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain Open
The cell’s mechanical environment is a fundamental determinant of its activity. Ostensibly, the cellular response is dependent on interactions between extracellular matrix deformations and the cell adhesome. Low-intensity vibration (LIV) i…
View article: Predicting Surgical Outcomes in Patients With Recurrent Patellar Dislocations
Predicting Surgical Outcomes in Patients With Recurrent Patellar Dislocations Open
Background: A lateral dislocation of the patella is a common injury in adolescents and young adults that is largely caused by underlying anatomic risk factors. Surgically managed patients have a significantly lower risk of recurrent disloc…
View article: Evaluation of machine learning techniques for real-time prediction of implanted lower limb mechanics
Evaluation of machine learning techniques for real-time prediction of implanted lower limb mechanics Open
Introduction Accurate prediction of knee biomechanics during total knee replacement (TKR) surgery is crucial for optimal outcomes. This study investigates the application of machine learning (ML) techniques for real-time prediction of knee…
View article: Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow
Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow Open
Aged individuals and astronauts experience bone loss despite rigorous physical activity. Bone mechanoresponse is in-part regulated by mesenchymal stem cells (MSCs) that respond to mechanical stimuli. Direct delivery of low intensity vibrat…
View article: Effects of Aging on Patellofemoral Joint Stress during Stair Negotiation on Challenging Surfaces
Effects of Aging on Patellofemoral Joint Stress during Stair Negotiation on Challenging Surfaces Open
This study examined the effect of age and surface on patellofemoral joint (PFJ) stress magnitude and waveform during stair ascent and descent tasks. A total of 12 young and 12 older adults had knee biomechanics quantified while they ascend…
View article: Computational Lower Limb Simulator Boundary Conditions to Reproduce Measured TKA Loading in a Cohort of Telemetric Implant Patients
Computational Lower Limb Simulator Boundary Conditions to Reproduce Measured TKA Loading in a Cohort of Telemetric Implant Patients Open
Recent advancements in computational modeling offer opportunities to refine total knee arthroplasty (TKA) design and treatment strategies. This study developed patient-specific simulator external boundary conditions (EBCs) using a PID-cont…
View article: Instantaneous Generation of Subject-Specific Finite Element Models of the Hip Capsule
Instantaneous Generation of Subject-Specific Finite Element Models of the Hip Capsule Open
Subject-specific hip capsule models could offer insights into impingement and dislocation risk when coupled with computer-aided surgery, but model calibration is time-consuming using traditional techniques. This study developed a framework…
View article: Surface, but Not Age, Impacts Lower Limb Joint Work during Walking and Stair Ascent
Surface, but Not Age, Impacts Lower Limb Joint Work during Walking and Stair Ascent Open
Older adults often suffer an accidental fall when navigating challenging surfaces during common locomotor tasks, such as walking and ascending stairs. This study examined the effect of slick and uneven surfaces on lower limb joint work in …
View article: Increased deformations are dispensable for cell mechanoresponse in engineered bone analogs mimicking aging bone marrow
Increased deformations are dispensable for cell mechanoresponse in engineered bone analogs mimicking aging bone marrow Open
Aged individuals and astronauts experience bone loss despite rigorous physical activity. Bone mechanoresponse is in-part regulated by mesenchymal stem cells (MSCs) that respond to mechanical stimuli. Direct delivery of low intensity vibrat…
View article: Modeling of active skeletal muscles: a 3D continuum approach incorporating multiple muscle interactions
Modeling of active skeletal muscles: a 3D continuum approach incorporating multiple muscle interactions Open
Skeletal muscles have a highly organized hierarchical structure, whose main function is to generate forces for movement and stability. To understand the complex heterogeneous behaviors of muscles, computational modeling has advanced as a n…
View article: Robust automatic hexahedral cartilage meshing framework enables population-based computational studies of the knee
Robust automatic hexahedral cartilage meshing framework enables population-based computational studies of the knee Open
Osteoarthritis of the knee is increasingly prevalent as our population ages, representing an increasing financial burden, and severely impacting quality of life. The invasiveness of in vivo procedures and the high cost of cadaveric studies…
View article: Integration of neural architecture within a finite element framework for improved neuromusculoskeletal modeling
Integration of neural architecture within a finite element framework for improved neuromusculoskeletal modeling Open
Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurod…
View article: ML Com Displacement for Older Adults During a Stair Descent on Challenging Surfaces
ML Com Displacement for Older Adults During a Stair Descent on Challenging Surfaces Open
Introduction: Older adults (OA) decreased neuromuscular function leads to compensatory strategies to reduce the likelihood of falling, including larger, more variable medio-lateral (ML) center of mass (COM) displacement than young adults (…
View article: Musculoskeletal Adaptations in Younger and Older Adults in Response to Challenging Conditions
Musculoskeletal Adaptations in Younger and Older Adults in Response to Challenging Conditions Open
Accidental falls are the leading cause of injury in adults 65 years and older. Previous research has identified significant fall factors including cognitive distractions, environmental conditions, and physical impairments while current res…
View article: Applying ASTM Standards to Tensile Tests of Musculoskeletal Soft Tissue: Methods to Reduce Grip Failures and Promote Reproducibility
Applying ASTM Standards to Tensile Tests of Musculoskeletal Soft Tissue: Methods to Reduce Grip Failures and Promote Reproducibility Open
Tensile testing is an essential experiment to assess the mechanical integrity of musculoskeletal soft tissues, yet standard test methods have not been developed to ensure the quality and reproducibility of these experiments. The ASTM Inter…
View article: Emerging Gene-Editing Modalities for Osteoarthritis
Emerging Gene-Editing Modalities for Osteoarthritis Open
Osteoarthritis (OA) is a pathological degenerative condition of the joints that is widely prevalent worldwide, resulting in significant pain, disability, and impaired quality of life. The diverse etiology and pathogenesis of OA can explain…
View article: Center of Biomedical Research Excellence in Matrix Biology: Building Research Infrastructure, Supporting Young Researchers, and Fostering Collaboration
Center of Biomedical Research Excellence in Matrix Biology: Building Research Infrastructure, Supporting Young Researchers, and Fostering Collaboration Open
The Center of Biomedical Research Excellence in Matrix Biology strives to improve our understanding of extracellular matrix at molecular, cellular, tissue, and organismal levels to generate new knowledge about pathophysiology, normal devel…
View article: "Miraculous and supernaturall effects" in the works of Henry More
"Miraculous and supernaturall effects" in the works of Henry More Open
Dr. Henry More [1614-1687], the prominent English theologian and philosopher, included hundreds of cases of “miraculous and supernaturall effects”, such as ghosts, witchcraft and divine intervention, throughout many of his works. Many hist…
View article: Computational evaluation of TKR stability using feedback‐controlled compressive loading
Computational evaluation of TKR stability using feedback‐controlled compressive loading Open
Pre‐clinical assessment of stability in total knee replacement is crucial for developing preferred implant performance. Current total knee replacement patients often experience joint instability that the human body addresses with compensat…
View article: A Combined Experimental and Computational Approach to Subject-Specific Analysis of Knee Joint Laxity
A Combined Experimental and Computational Approach to Subject-Specific Analysis of Knee Joint Laxity Open
Modeling complex knee biomechanics is a continual challenge, which has resulted in many models of varying levels of quality, complexity, and validation. Beyond modeling healthy knees, accurately mimicking pathologic knee mechanics, such as…
View article: Subject‐specific modeling of muscle force and knee contact in total knee arthroplasty
Subject‐specific modeling of muscle force and knee contact in total knee arthroplasty Open
Understanding the mechanical loading environment and resulting joint mechanics for activities of daily living in total knee arthroplasty is essential to continuous improvement in implant design. Although survivorship of these devices is go…