Chris Hansell
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View article: Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge
Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge Open
Lung structural cells form barriers against pathogens and trigger immune responses following infections. This leads to the recruitment of innate and adaptive immune cells some of which remain within the lung and contribute to enhanced path…
View article: Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza Open
Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) ch…
View article: Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure
Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure Open
OBJECTIVES: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) have therapeutic effects in diabetes mellitus. Prior clinical studies suggest incretins are prognostic of adverse outcomes…
View article: Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza Open
Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) ch…
View article: Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy
Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy Open
Chemokines regulate leukocyte navigation to inflamed sites and specific tissue locales and may therefore be useful for ensuring accurate homing of cell therapeutic products. We, and others, have shown that atypical chemokine receptor 2 (AC…
View article: Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge
Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge Open
Lung structural cells, including epithelial cells and fibroblasts, form barriers against pathogens and trigger immune responses following infections such as influenza A virus. This response leads to the recruitment of innate and adaptive i…
View article: S112 Infection experienced lung stromal cells provide early immune protection that is independent of the adaptive immune response
S112 Infection experienced lung stromal cells provide early immune protection that is independent of the adaptive immune response Open
Introduction and Objectives Influenza A virus (IAV) infections contribute significantly to global mortality. Stromal cells may be permanently altered by inflammatory responses, a process known as trained immunity. We hypothesize that viral…
View article: DOP01 A multi-centre study to explore the prevalence of Inflammatory Bowel Disease indicators in patients with moderate- to- severe psoriasis: Baseline results from the EPIC study
DOP01 A multi-centre study to explore the prevalence of Inflammatory Bowel Disease indicators in patients with moderate- to- severe psoriasis: Baseline results from the EPIC study Open
Background Evidence suggests there is an increased incidence of inflammatory bowel disease (IBD) in the psoriasis (PsO) population. However prior studies may have underestimated the degree of this association, by not considering (pre-)clin…
View article: T4 Reinfection with influenza a virus leads to rapid changes in immunomodulatory molecules and inflammatory subtypes of lung fibroblasts and epithelial cells
T4 Reinfection with influenza a virus leads to rapid changes in immunomodulatory molecules and inflammatory subtypes of lung fibroblasts and epithelial cells Open
Introduction and Objectives Influenza A virus (IAV) induces respiratory infections resulting in significant global mortality. Stromal cells are essential sources of chemokines and growth factors that promote immune cell survival and anti-v…
View article: P165 Disease-related worries and concerns in UK patients with ulcerative colitis: 2-year data from ICONIC
P165 Disease-related worries and concerns in UK patients with ulcerative colitis: 2-year data from ICONIC Open
Introduction ICONIC is the largest prospective, multi-country observational study assessing cumulative disease-associated burden in adults with ulcerative colitis (UC) under routine care. This local subanalysis evaluated patient worries an…
View article: P164 Correlation between physician and patient disease assessments in ulcerative colitis: 2-Year UK data from ICONIC
P164 Correlation between physician and patient disease assessments in ulcerative colitis: 2-Year UK data from ICONIC Open
Introduction ICONIC is the largest prospective multi-country observational study assessing burden in adult ulcerative colitis (UC) patients under routine care. This local subanalysis evaluated the level of agreement between UK patients and…
View article: P135 Disease-related worries and concerns in UK patients with ulcerative colitis: 2-year data from ICONIC
P135 Disease-related worries and concerns in UK patients with ulcerative colitis: 2-year data from ICONIC Open
Background ICONIC is the largest ongoing, prospective, multi-country observational study assessing cumulative disease-associated burden in adults with ulcerative colitis (UC) under routine care. This local subanalysis evaluated patient wor…
View article: P208 Correlation between physician and patient disease assessments in ulcerative colitis: 2-year UK data from the ICONIC study
P208 Correlation between physician and patient disease assessments in ulcerative colitis: 2-year UK data from the ICONIC study Open
Background ICONIC is the largest prospective multi-country (n = 33) observational study assessing burden in adult ulcerative colitis (UC) patients under routine care. Both patient and physician assessments of disease severity, activity and…
View article: Role of innate immune responses in the effectiveness of oncolytic adenovirus as an anticancer agent
Role of innate immune responses in the effectiveness of oncolytic adenovirus as an anticancer agent Open