Chris Imray
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View article: Changes in metabolic energy measures for daily living activities and exercise in men and women following arduous activity in Antarctica
Changes in metabolic energy measures for daily living activities and exercise in men and women following arduous activity in Antarctica Open
This study reports pre- to post-expedition (pre|post) changes in energy expenditure and substrate utilisation during daily living activities (DLAs including rest, sleep, modest exercise, sedentary work and leisure) and maximum aerobic powe…
View article: A vein bypass first <i>versus</i> a best endovascular treatment first revascularization strategy for patients with chronic limb-threatening ischaemia who require an infra-popliteal, with or without an additional more proximal infra-inguinal, revascularization procedure to restore limb perfusion: the BASIL-2 within-trial health economic analysis
A vein bypass first <i>versus</i> a best endovascular treatment first revascularization strategy for patients with chronic limb-threatening ischaemia who require an infra-popliteal, with or without an additional more proximal infra-inguinal, revascularization procedure to restore limb perfusion: the BASIL-2 within-trial health economic analysis Open
Background Chronic limb-threatening ischaemia (CLTI) places a considerable socioeconomic burden health and social care systems worldwide. The objective of this health economic analysis was to investigate the cost-effectiveness (CEA) and co…
View article: Changes in body composition and average daily energy expenditure of men and women during arduous extended polar travel
Changes in body composition and average daily energy expenditure of men and women during arduous extended polar travel Open
Weight and skin-fold measurements were made at five-day intervals during a 47-day expedition by six men and three women from the edge of the sea ice to the South Pole. From these, together with detailed manual records of the nutrition for …
View article: REPAIRS Delphi: A UK and Ireland Consensus Statement on the Management of Infected Arterial Pseudoaneurysms Secondary to Groin Injecting Drug Use
REPAIRS Delphi: A UK and Ireland Consensus Statement on the Management of Infected Arterial Pseudoaneurysms Secondary to Groin Injecting Drug Use Open
This comprehensive consensus statement provides a strong insight into the standard of care for these patients.
View article: Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth
Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth Open
Background There is a clinical need for treatments that can slow or prevent the growth of an abdominal aortic aneurysm, not only to reduce the need for surgery, but to provide a means to treat those who cannot undergo surgery. Methods Anal…
View article: Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude
Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude Open
Berendsen, Remco R., Peter Bärtsch, Buddha Basnyat, Marc Moritz Berger, Peter Hackett, Andrew M. Luks, Jean-Paul Richalet, Ken Zafren, Bengt Kayser, and the STAK Plenary Group. Strengthening altitude knowledge: a Delphi study to define min…
View article: The Use of the PUlse oximeter in Limb Salvage. The Pulse study
The Use of the PUlse oximeter in Limb Salvage. The Pulse study Open
Purpose Does a non-invasive pulse oximeter probe accurately indicate limb ischaemia with inflation of a tourniquet? How are the pulse waveform, perfusion index and oxygen saturations affected? Does pulse oximetry return to normal with rest…
View article: 663 Potential for Prophylactic Antibiotics in Renal Transplantation: A Retrospective Study of Kidney Perfusion Fluid Cultures and Kidney Cold Ischaemic Time
663 Potential for Prophylactic Antibiotics in Renal Transplantation: A Retrospective Study of Kidney Perfusion Fluid Cultures and Kidney Cold Ischaemic Time Open
Aim Infection is a significant cause of morbidity in kidney transplantation, and it is believed that an increased cold ischemic time is an independent risk factor. Identification of common pathogens in perfusion fluids, as well as the safe…
View article: 407 Surgical Site Infection of Renal Transplant Patients Stratified by BMI
407 Surgical Site Infection of Renal Transplant Patients Stratified by BMI Open
Aim Surgical site infection increases with BMI with values ranging from 20% to greater than 40%. There are increasing numbers of obese patients (BMI >30) undergoing transplants and this audit aims to review the incidence and grade of su…
View article: Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial
Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial Open
Background: Patients with symptomatic internal carotid artery (ICA) stenosis are at high risk of recurrent ischemic stroke and require early interventional treatment and antiplatelet therapy. Increased bleeding rates might counterbalance t…
View article: HLA Antibody Incompatible Renal Transplantation: Long-term Outcomes Similar to Deceased Donor Transplantation
HLA Antibody Incompatible Renal Transplantation: Long-term Outcomes Similar to Deceased Donor Transplantation Open
Background. HLA incompatible renal transplantation still remains one of best therapeutic options for a subgroup of patients who are highly sensitized and difficult to match but not much is known about its long-term graft and patient surviv…
View article: Physiological responses during ascent to high altitude and the incidence of acute mountain sickness
Physiological responses during ascent to high altitude and the incidence of acute mountain sickness Open
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim of this study was to describe the relationship between physiological variables and the incidence of AMS during ascent to 5300 m. A tota…
View article: Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m)
Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m) Open
Objective Altitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. This study examined the antihypertensive…
View article: Identifying the research priorities of healthcare professionals in UK vascular surgery: modified Delphi approach
Identifying the research priorities of healthcare professionals in UK vascular surgery: modified Delphi approach Open
Background The Vascular Research Collaborative was established to develop a national research strategy for patients with vascular disease in the UK. This project aimed to establish national research priorities in this patient group. Method…
View article: A comparison of the metabolic effects of sustained strenuous activity in polar environments on men and women
A comparison of the metabolic effects of sustained strenuous activity in polar environments on men and women Open
This study investigates differences in pre- to post-expedition energy expenditure, substrate utilisation and body composition, between the all-male Spear17 (SP-17) and all-female Ice Maiden (IM) transantarctic expeditions (IM: N = 6, 61 da…
View article: C3d‐positive donor‐specific antibodies have a role in pretransplant risk stratification of cross‐match‐positive HLA‐incompatible renal transplantation: United Kingdom multicentre study
C3d‐positive donor‐specific antibodies have a role in pretransplant risk stratification of cross‐match‐positive HLA‐incompatible renal transplantation: United Kingdom multicentre study Open
Anti-HLA-antibody characteristics aid to risk-stratify patients and improve long-term renal graft outcomes. Complement activation by donor-specific antibody (DSA) is an important characteristic that may determine renal allograft outcome. T…
View article: Nonfreezing Cold Injuries Among Long-Distance Polar Rowers
Nonfreezing Cold Injuries Among Long-Distance Polar Rowers Open
Introduction Nonfreezing cold injury (NFCI) is a peripheral cold injury that occurs when the extremities are exposed to cold temperatures, at or near the freezing point, for sustained periods of time (48–96 h at temperatures of usually aro…
View article: Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria
Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria Open
Introduction Proteinuria increases at altitude and with exercise, potentially as a result of hypoxia. Using urinary alpha-1 acid glycoprotein (α1-AGP) levels as a sensitive marker of proteinuria, we examined the impact of relative hypoxia …
View article: Post-flight confusion: does flying affect the brain?
Post-flight confusion: does flying affect the brain? Open
This paper describes a condition termed post-flight confusion using anecdotal and clinical observations. It reviews research from the fields of aviation and altitude medicine and how this could apply to some physiological changes that happ…
View article: Multimodal analysis of the effects of dexamethasone on high-altitude cerebral oedema: protocol for a pilot study
Multimodal analysis of the effects of dexamethasone on high-altitude cerebral oedema: protocol for a pilot study Open
Background Acute mountain sickness (AMS) is a cluster of symptoms that commonly occur in those ascending to high altitudes. Symptoms can include headaches, nausea, insomnia and fatigue. Exposure to high altitude can also lead to high-altit…
View article: Metabolic rate and substrate utilisation resilience in men undertaking polar expeditionary travel
Metabolic rate and substrate utilisation resilience in men undertaking polar expeditionary travel Open
The energy expenditure and substrate utilisation were measured in 5 men pre- and post- a 67 day, 1750km unassisted Antarctic traverse from the Hercules Inlet to the Ross Sea Ice via the South pole pulling sledges weighing 120kg whilst expe…
View article: Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update
Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update Open
The Wilderness Medical Society convened an expert panel to develop a set of evidence-based guidelines for prevention and treatment of frostbite. We present a review of pertinent pathophysiology. We then discuss primary and secondary preven…