Chris M. Long
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View article: Reinforcement of Fibrillar Collagen Hydrogels with Bioorthogonal Covalent Crosslinks
Reinforcement of Fibrillar Collagen Hydrogels with Bioorthogonal Covalent Crosslinks Open
Bioorthogonal covalent crosslinking stabilizes collagen type I hydrogels, improving their structural integrity for tissue engineering applications with encapsulated living cells. The chemical modification required for crosslinking, however…
View article: Interpenetrating networks of fibrillar and amorphous collagen promote cell spreading and hydrogel stability
Interpenetrating networks of fibrillar and amorphous collagen promote cell spreading and hydrogel stability Open
Hydrogels composed of collagen, the most abundant protein in the human body, are widely used as scaffolds for tissue engineering due to their ability to support cellular activity. However, collagen hydrogels with encapsulated cells often e…
Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arrays Open
Preclinical methods are needed for screening potential Alzheimer’s disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease. This would require a phe…
View article: APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia Open
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells 1 . However, the relationship between lipid metabolism in glia and Alzheime…
View article: APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia Open
Several genetic risk factors for Alzheimer’s Disease (AD) implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pat…
Substrate-Independent Technique of III-V Heterogeneous Integration of Focal Plane Arrays and Lasers Open
We report on a two-step technique for post-bond III-V substrate removal involving precision mechanical milling and selective chemical etching. We show results on GaAs, GaSb, InP, and InAs substrates and from mm-scale chips to wafers.
Tuning Polymer Hydrophilicity to Regulate Gel Mechanics and Encapsulated Cell Morphology Open
Mechanically tunable hydrogels are attractive platforms for 3D cell culture, as hydrogel stiffness plays an important role in cell behavior. Traditionally, hydrogel stiffness has been controlled through altering either the polymer concentr…