Christopher McCabe
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View article: Putting the substance in substantial evidence: an evidence-based approach to flexible drug regulation
Putting the substance in substantial evidence: an evidence-based approach to flexible drug regulation Open
For new drugs or indications, substantial evidence of clinical effectiveness is required for market authorization. In most jurisdictions, substantial evidence is not explicitly defined. Health regulators exercise discretion and are increas…
View article: Reducing ethyl chloride usage with innovative cool sticks
Reducing ethyl chloride usage with innovative cool sticks Open
Background: More than 90% of UK Caesarean sections are done with neuro-axial blockade.1 Until recently, the main ways of testing the level of neuro-axial blockade in anaesthesia has been through checking the modalities of coarse touch with…
View article: Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer
Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer Open
New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying alrea…
View article: UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings Open
Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying vari…
View article: Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke
Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke Open
Acute hyperglycaemia and chronic hypertension worsen stroke outcome but their impact on collateral perfusion, a determinant of penumbral life span, is poorly understood. Laser-speckle contrast imaging (LSCI) was used to determine the influ…
View article: Preclinical Validation of the Therapeutic Potential of Glasgow Oxygen Level Dependent (GOLD) Technology: a Theranostic for Acute Stroke
Preclinical Validation of the Therapeutic Potential of Glasgow Oxygen Level Dependent (GOLD) Technology: a Theranostic for Acute Stroke Open
In acute stroke patients, penumbral tissue is non-functioning but potentially salvageable within a time window of variable duration and represents target tissue for rescue. Reperfusion by thrombolysis and/or thrombectomy can rescue penumbr…
View article: Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies
Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies Open
Despite promising preclinical data, few novel stroke therapies have shown efficacy in man. Efforts to improve standards in conduct and reporting of preclinical research are ongoing. In clinical trials, inconsistency in outcome measures led…
View article: Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology Open
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-cli…
View article: The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) Open
Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic str…
View article: Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats
Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats Open
Photoperiod disruption, which occurs during shift work, is associated with changes in metabolism or physiology (e.g. hypertension and hyperglycaemia) that have the potential to adversely affect stroke outcome. We sought to investigate if p…
View article: MRI Variability in a Rat Model of Stroke
MRI Variability in a Rat Model of Stroke Open
This dataset contains T2-weighted MRI scans of 21 different Sprague-Dawley rats that were subjected to permanent middle cerebral artery occlusion, as part of a study assessing the influence of gender in the progression of ischaemic injury.…