Chris McGlory
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View article: The impact of menstrual phase on lower limb microvascular function, ERα, eNOS, and p-eNOS protein in premenopausal females
The impact of menstrual phase on lower limb microvascular function, ERα, eNOS, and p-eNOS protein in premenopausal females Open
This study provides the first parallel assessments of microvascular function and estrogen-related protein content across the early to late follicular phases of the menstrual cycle in humans. Both microvascular function assessed via passive…
View article: The influence of biological sex on skeletal muscle phospholipid membrane composition in response to omega n-3 polyunsaturated fatty acid supplementation and washout in humans
The influence of biological sex on skeletal muscle phospholipid membrane composition in response to omega n-3 polyunsaturated fatty acid supplementation and washout in humans Open
Omega n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with reduced inflammation, protection against cardiovascular disease, and improved cognitive function. There is also evidence that n-3 PUFA intake impacts skeletal muscle…
View article: Hemoglobin synthesis rates in young trained and untrained males and females are not different
Hemoglobin synthesis rates in young trained and untrained males and females are not different Open
We employed deuterated water ( 2 H 2 O) to compare the fractional synthetic rate (FSR) of hemoglobin in trained ( n = 10) and untrained humans ( n = 10). Participants had a mean V̇O 2 max of 49.8 [SD: 10.9] mL/kg/min, hemoglobin mass of 775…
View article: Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle
Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle Open
The effect of biological sex on rates of skeletal muscle mitochondrial respiration supported by creatine‐dependent phosphate shuttling was previously unknown. The aim of this investigation was to test the hypothesis that females and males …
View article: Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?
Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here? Open
Understanding the turnover of proteins in tissues gives information as to how external stimuli result in phenotypic change. Nowhere is such phenotypic change more conspicuous than skeletal muscle, which can be effectively remodelled by inc…
View article: Memorial Symposium-3: Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth
Memorial Symposium-3: Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth Open
View article: Platelet bioenergetics correlate with skeletal muscle metabolism in C57BL/6J mice
Platelet bioenergetics correlate with skeletal muscle metabolism in C57BL/6J mice Open
Summary Skeletal muscle insulin resistance is a key step in progression of cardiometabolic disease, and impaired mitochondrial bioenergetics has been implicated. However, mitochondrial bioenergetic research in skeletal muscle is limited by…
View article: Nutritional intervention to enhance recovery after arthroscopic knee surgery in adults: a randomized controlled pilot trial
Nutritional intervention to enhance recovery after arthroscopic knee surgery in adults: a randomized controlled pilot trial Open
ClinicalTrials.gov, NCT06233825. Registered 31 January 2024. https://clinicaltrials.gov/study/NCT06233825?term=NCT06233825&rank=1.
View article: Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth
Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth Open
A human model of unilateral endurance versus resistance exercise, in conjunction with deep phosphoproteomic analyses, was used to identify exercise mode-specific phosphorylation events. Among the outcomes, a resistance exercise-specific cl…
View article: Plantar flexor strength and size decrease following single‐leg disuse in uninjured adults: A meta‐analysis
Plantar flexor strength and size decrease following single‐leg disuse in uninjured adults: A meta‐analysis Open
Introduction Plantar flexors play a pivotal role in human locomotion and balance. Several original research studies and systematic reviews have characterised the impact of single‐leg disuse on plantar flexor strength and size. However, no …
View article: Application of<sup>2</sup>H<sub>2</sub>O to quantify red blood cell protein synthesis rates in young trained and untrained males and females
Application of<sup>2</sup>H<sub>2</sub>O to quantify red blood cell protein synthesis rates in young trained and untrained males and females Open
Aim Compare the fractional synthetic rate (FSR) of hemoglobin in trained and untrained humans (Hb FSR). Methods We employed deuterated water ( 2 H 2 O) to measure Hb FSR in young males (n=10) and females (n=10) who were aerobically trained…
View article: Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling Open
A majority of human genes produce non-protein-coding RNA (ncRNA), and some have roles in development and disease. Neither ncRNA nor human skeletal muscle is ideally studied using short-read sequencing, so we used a customized RNA pipeline …
View article: Impact of exercise and fasting on mitochondrial regulators in human muscle
Impact of exercise and fasting on mitochondrial regulators in human muscle Open
Objectives To investigate the impact of acute energetic stress (acute HIIE and fasting) on ERRγ , PPARβ , NR1D1 , NR4A1 , and TFEB in human skeletal muscle. Methods The current study performed secondary analyses using muscle biopsy samples…
View article: Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling Open
A majority of human genes produce non-protein-coding RNA (ncRNA), and some have roles in development and disease. Neither ncRNA nor human skeletal muscle is ideally studied using short-read sequencing, so we used a customised RNA pipeline …
View article: Quantifying variability associated with high-resolution respirometry in human permeabilized skeletal muscle fibers
Quantifying variability associated with high-resolution respirometry in human permeabilized skeletal muscle fibers Open
Rates of skeletal muscle mitochondrial respiration are often measured using an Oroboros Oxygraph-2K (O2K) high-resolution respirometer. The purpose of this investigation was to determine the coefficients of variation (CV) and technical err…
View article: Low baseline ribosome‐related gene expression and resistance training‐induced declines in ribosome‐related gene expression are associated with skeletal muscle hypertrophy in young men and women
Low baseline ribosome‐related gene expression and resistance training‐induced declines in ribosome‐related gene expression are associated with skeletal muscle hypertrophy in young men and women Open
Ribosomes are essential cellular machinery for protein synthesis. It is hypothesised that ribosome content supports muscle growth and that individuals with more ribosomes have greater increases in muscle size following resistance training …
View article: Lipidomic studies reveal two specific circulating phosphatidylcholines as surrogate biomarkers of the omega-3 index
Lipidomic studies reveal two specific circulating phosphatidylcholines as surrogate biomarkers of the omega-3 index Open
Optimal dietary intake of omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFAs) is critical to human health across the lifespan. However, omega-3 index (O3I) determination is not routinely assessed due to complicated procedures for n…
View article: Single‐leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: A systematic review and meta‐analysis
Single‐leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: A systematic review and meta‐analysis Open
We aimed to quantify declines from baseline in lower limb skeletal muscle size and strength of uninjured adults following single‐leg disuse. We searched EMBASE, Medline, CINAHL, and CCRCT up to 30 January 2022. Studies were included in the…
View article: Does initial skeletal muscle size or sex affect the magnitude of muscle loss in response to 14 days immobilization?
Does initial skeletal muscle size or sex affect the magnitude of muscle loss in response to 14 days immobilization? Open
We aimed to determine whether there was a relationship between pre-immobilization skeletal muscle size and the magnitude of muscle atrophy following 14 days of unilateral lower limb immobilization. Our findings ( n = 30) show that pre-immo…
View article: Aerobic conditioning alters the satellite cell and ribosome response to acute eccentric contractions in young men and women
Aerobic conditioning alters the satellite cell and ribosome response to acute eccentric contractions in young men and women Open
Satellite cells (SCs) and ribosomes are key determinants of the skeletal muscle adaptive response. Both are thought to increase acutely after resistance exercise and chronically with resistance training. However, the acute SC and ribosome …
View article: Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown
Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown Open
Background We determined the short‐term (i.e. 4 days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted‐fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB]. Metho…
View article: Sex-Based Differences in the Myogenic Response and Inflammatory Gene Expression Following Eccentric Contractions in Humans
Sex-Based Differences in the Myogenic Response and Inflammatory Gene Expression Following Eccentric Contractions in Humans Open
After muscle injury, the interaction between muscle satellite cells (SC) and the immune response is instrumental for the repair and regeneration of skeletal muscle tissue. Studies have reported sex-based differences in the skeletal muscle …
View article: Fish Oil for Healthy Aging: Potential Application to Master Athletes
Fish Oil for Healthy Aging: Potential Application to Master Athletes Open
Master athletes perform high volumes of exercise training yet display lower levels of physical functioning and exercise performance when compared with younger athletes. Several reports in the clinical literature show that long chain n-3 po…
View article: Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short‐term disuse in healthy younger humans
Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short‐term disuse in healthy younger humans Open
Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular…
View article: An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training‐induced muscle fiber hypertrophy in younger men
An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training‐induced muscle fiber hypertrophy in younger men Open
We examined the association between genotype and resistance training‐induced changes (12 wk) in dual x‐ray energy absorptiometry (DXA)‐derived lean soft tissue mass (LSTM) as well as muscle fiber cross‐sectional area (fCSA; vastus laterali…
View article: Brief Vigorous Stair Climbing Effectively Improves Cardiorespiratory Fitness in Patients With Coronary Artery Disease: A Randomized Trial
Brief Vigorous Stair Climbing Effectively Improves Cardiorespiratory Fitness in Patients With Coronary Artery Disease: A Randomized Trial Open
Background: Cardiac rehabilitation exercise reduces the risk of secondary cardiovascular disease. Interval training is a time-efficient alternative to traditional cardiac rehabilitation exercise and stair climbing is an accessible means. W…
View article: Methodological considerations for and validation of the ultrasonographic determination of human skeletal muscle hypertrophy and atrophy
Methodological considerations for and validation of the ultrasonographic determination of human skeletal muscle hypertrophy and atrophy Open
Magnetic resonance imaging (MRI) is the current gold standard for measuring changes in muscle size (cross‐sectional area [CSA] and volume) but can be cost‐prohibitive and resource‐intensive. We evaluated the validity of B‐mode ultrasonogra…
View article: Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States Open
View article: Human skeletal muscle metabolic responses to 6 days of high‐fat overfeeding are associated with dietary n‐3PUFA content and muscle oxidative capacity
Human skeletal muscle metabolic responses to 6 days of high‐fat overfeeding are associated with dietary n‐3PUFA content and muscle oxidative capacity Open
Understanding human physiological responses to high-fat energy excess (HFEE) may help combat the development of metabolic disease. We aimed to investigate the impact of manipulating the n-3PUFA content of HFEE diets on whole-body and skele…
View article: Potato Protein Isolate Stimulates Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women
Potato Protein Isolate Stimulates Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women Open
Skeletal muscle myofibrillar protein synthesis (MPS) increases in response to protein feeding and to resistance exercise (RE), where each stimuli acts synergistically when combined. The efficacy of plant proteins such as potato protein (PP…