Christopher M. Morris
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View article: Variability of longitudinal sleep monitoring in amyloid‐negative and amyloid‐positive cognitively unimpaired and mildly impaired older adults
Variability of longitudinal sleep monitoring in amyloid‐negative and amyloid‐positive cognitively unimpaired and mildly impaired older adults Open
INTRODUCTION Sleep disturbances are associated with Alzheimer's disease (AD) pathology and cognitive symptoms, but few studies have longitudinally assessed sleep, AD biomarkers, and cognition. Understanding how sleep changes over time in o…
View article: Clinical progression on CDR‐SB©: Progression‐free time at each 0.5 unit level in dominantly inherited and sporadic Alzheimer's disease populations
Clinical progression on CDR‐SB©: Progression‐free time at each 0.5 unit level in dominantly inherited and sporadic Alzheimer's disease populations Open
INTRODUCTION Clinical Dementia Rating Sum of Boxes (CDR‐SB) is a reliable and clinically meaningful composite for assessing treatment effects in Alzheimer's disease (AD) clinical trials. Small CDR‐SB differences at the end of a trial often…
View article: Type‐Specific Single‐Neuron Analysis Reveals Mitochondrial <scp>DNA</scp> Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes
Type‐Specific Single‐Neuron Analysis Reveals Mitochondrial <span>DNA</span> Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes Open
The age‐associated neurodegenerative disorder, Lewy body dementia (LBD), encompasses neuropsychiatric symptom‐overlapping Dementia with Lewy bodies (DLB) and Parkinson's Disease with Dementia (PDD). We characterised how differential mitoch…
View article: Lecanemab Treatment in a Specialty Memory Clinic
Lecanemab Treatment in a Specialty Memory Clinic Open
Importance Two monoclonal antibodies targeting amyloid plaques, lecanemab and donanemab, have received traditional US Food and Drug Administration (FDA) approval for the treatment of early symptomatic Alzheimer disease (AD). The most signi…
View article: Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease
Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease Open
INTRODUCTION β‐synuclein is a promising blood marker to track synaptic degeneration in Alzheimer's disease (AD) but changes in preclinical AD are unclear. METHODS We investigated serum β‐synuclein in 69 cognitively unimpaired mutation non‐…
View article: A lipid-based delivery platform for pulsatile delivery of teriparatide
A lipid-based delivery platform for pulsatile delivery of teriparatide Open
Teriparatide (and analogue peptides) are the only FDA approved anabolic treatments for osteoporosis. Current therapies are administered as a daily subcutaneous injection, which limits patient adherence and clinical efficacy. To achieve the…
View article: Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra
Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra Open
Neuromelanin-pigmented neurons of the substantia nigra are selectively lost during the progression of Parkinson’s disease. These neurons accumulate iron in the disease state, and iron-mediated neuron damage is implicated in cell death. Ani…
View article: MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study Open
Wellcome Trust, Rotha Abraham Trust, Brain Research UK, the Dolby Fund, Dementia Research Institute (Medical Research Council), US National Institutes of Health, and the Mayo Clinic Foundation.
View article: Dopaminergic Changes in the Subgenual Cingulate Cortex in Dementia with Lewy Bodies Associates with Presence of Depression
Dopaminergic Changes in the Subgenual Cingulate Cortex in Dementia with Lewy Bodies Associates with Presence of Depression Open
In addition to the core clinical features of fluctuating cognition, visual hallucinations, and parkinsonism, individuals with dementia with Lewy bodies (DLB) frequently experience chronic and debilitating major depression. Treatment of dep…
View article: Dopaminergic Changes in the Subgenual Cingulate Cortex in Dementia with Lewy Bodies Associates with Presence of Depression
Dopaminergic Changes in the Subgenual Cingulate Cortex in Dementia with Lewy Bodies Associates with Presence of Depression Open
In addition to the core clinical features of fluctuating cognition, visual hallucinations, and parkinsonism, individuals with dementia with Lewy bodies (DLB) frequently experience chronic and debilitating major depression. Treatment of dep…
View article: Investigation of the genetic aetiology of Lewy body diseases with and without dementia
Investigation of the genetic aetiology of Lewy body diseases with and without dementia Open
Up to 80% of Parkinson's disease patients develop dementia, but time to dementia varies widely from motor symptom onset. Dementia with Lewy bodies presents with clinical features similar to Parkinson’s disease dementia, but cognitive impai…
View article: Association of cardiovascular disease management drugs with Lewy body dementia: a case–control study
Association of cardiovascular disease management drugs with Lewy body dementia: a case–control study Open
Lewy body dementia is the second most common neurodegenerative dementia after Alzheimer’s disease. Disease-modifying therapies for this disabling neuropsychiatric condition are critically needed. To identify drugs associated with the risk …
View article: Ubiquitin‐Proteasome System in Different Staging of Dominantly Inherited Alzheimer’s Disease
Ubiquitin‐Proteasome System in Different Staging of Dominantly Inherited Alzheimer’s Disease Open
Background Both sporadic and dominantly inherited Alzheimer’s disease (DIAD) present with similar pathobiology and symptoms. A loss of proteostasis in AD has been identified with recent studies highlighting the role of ubiquitin‐dependent …
View article: Neurodevelopmental outcomes in children and adults with Fetal Valproate Spectrum Disorder: A contribution from the ConcePTION project
Neurodevelopmental outcomes in children and adults with Fetal Valproate Spectrum Disorder: A contribution from the ConcePTION project Open
Children and young adults with a diagnosis of FVSD are at an increased risk of a range of altered neurodevelopmental outcomes, highlighting the need for a multidisciplinary approach to clinical management across the lifespan.
View article: Supplementary Figure 2 from TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis
Supplementary Figure 2 from TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis Open
Supplementary Figure 2 - PDF file 42K, The effect of myeloid specific deletion of Tgfbr2 on tumor growth and metastasis
View article: Supplementary Figure 10 from TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis
Supplementary Figure 10 from TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis Open
Supplementary Figure 10 - PDF file 82K, Time course study for in vivo cell trafficking; the expression of TGFbeta ligands and receptors in myeloid cells and subsets
View article: Ultrafast CMOS image sensors and data-enabled super-resolution for multimodal radiographic imaging and tomography
Ultrafast CMOS image sensors and data-enabled super-resolution for multimodal radiographic imaging and tomography Open
We summarize recent progress in ultrafast Complementary Metal Oxide\nSemiconductor (CMOS) image sensor development and the application of neural\nnetworks for post-processing of CMOS and charge-coupled device (CCD) image data\nto achieve s…
View article: Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina
Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina Open
Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific RP…
View article: Blood mRNA Expression in Alzheimer's Disease and Dementia With Lewy Bodies
Blood mRNA Expression in Alzheimer's Disease and Dementia With Lewy Bodies Open
OBJECTIVES: The objective of this study was to investigate the expression of genes in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), both at the mild cognitive impairment (MCI) and dementia stages, to improve our understandi…
View article: Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFβ signalling pathway.
Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFβ signalling pathway. Open
Cellular senescence is associated with aging but also impacts various physiological and pathological processes such as embryonic development and wound healing. Factors secreted by senescent cells can affect their microenvironment, includin…
View article: Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state Open
Idiopathic Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson’s disease research has mainly focused on nigral dopaminergic neurons…
View article: Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups
Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups Open
The APOE locus is strongly associated with risk for developing Alzheimer’s disease and dementia with Lewy bodies. In particular, the role of the APOE ε4 allele as a putative driver of α-synuclein pathology is a topic of intense debate. Her…
View article: Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations Open
Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long‐term disease control/cure. There are significant inter‐patient differences in response, both in terms of efficacy and toxicity (frequent…
View article: Forecasting stroke-like episodes and outcomes in mitochondrial disease
Forecasting stroke-like episodes and outcomes in mitochondrial disease Open
In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes and to identify associated risk pr…