Explanipedia

Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling Open

Moza M. Al‐Owais, Nishani T. Hettiarachchi, Mark Dallas, Jason L. Scragg, Jonathan D. Lippiat , et al. · 2023

The voltage-gated K + channel plays a key role in atrial excitability, conducting the ultra-rapid rectifier K + current (I Kur ) and contributing to the repolarization of the atrial action potential. In this study, we examine its regulatio…

The AMPK Activator A-769662 Inhibits Human TASK-3 Potassium Channels in an AMPK-Independent Manner Open

Esraa A. Said, Ryan W. Lewis, Mark Dallas, Chris Peers, Fiona A. Ross , et al. · 2023

Publisher Correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

Correction to: Communications Biology https://doi.org/10.1038/s42003-022-03583-7, published online 29 June 2022.

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

LKB1 is the gatekeeper of carotid body chemo-sensing and the hypoxic ventilatory response: deficiency precipitates Cheyne Stokes breathing Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to the body and is primarily mediated by the carotid bodies. Here we reveal that carotid body afferent discharge during hypoxia and hypercapnia is deter…

The AMPK activator A-769662 inhibits human TASK3 potassium channels in an AMPK-independent manner Open

Esraa A. Said, Ryan W. Lewis, Mark Dallas, Chris Peers, Fiona A. Ross , et al. · 2022

Heteromeric TASK1/3 channels play a fundamental role in oxygen-sensing by carotid body type 1 cells, where hypoxia-induced inhibition of TASK3 and/or TASK1/3 potassium currents leads to depolarisation, voltage-gated calcium entry, exocytot…

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1 Open

Mark Dallas, Moza M. Al‐Owais, Nishani T. Hettiarachchi, M. Scott Vandiver, Heledd Jarosz-Griffiths , et al. · 2021

Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism Open

Faye Louise Styles, Moza M. Al‐Owais, Jason L. Scragg, Eulashini Chuntharpursat‐Bon, Nishani T. Hettiarachchi , et al. · 2021

Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle Open

Yuan-Ming Tsai, Frederick Jones, Pierce Mullen, Karen E. Porter, Derek S. Steele , et al. · 2020

Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction cou…

Author Index Open

Abdel Galil, An Hai-Long, Anita Ayer, Bruno de Carvalho Barros, David G. Beer , et al. · 2020

Delineating an extracellular redox-sensitive module in T-type Ca2+ channels Open

Dongyang Huang, Sai Shi, Ce Liang, Xiaoyu Zhang, Xiaona Du , et al. · 2020

T-type (Cav3) Ca²⁺ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca²⁺ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using…

Carbon Monoxide Effects on Electrophysiological Mechanisms of Ventricular Arrhythmogenesis Open

Moza M. Al‐Owais, Arun V. Holden, Chris Peers, Derek S. Steele, Alan P. Benson · 2018

Increased dissolved carbon monoxide decreases ICa,L IK1 and IKr, and increases late INa currents in rat and guinea pig patch-clamped isolated ventricular myocytes.Action potentials are prolonged.These effects are reproduced by scaling the …

Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration Open

Lan Cheng, Moza M. Al‐Owais, Manuel Covarrubias, Walter J. Koch, David R. Manning , et al. · 2018

SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric G_i proteins in many cell types, including cardiomyocytes. In this study, we report that activation of SMO with SHH (Sonic Hedgehog) or …

The EPAC2 Inhibitor ESI-05 Prolongs the Action Potential and Increases Susceptibility to EAD Arrhythmias Open

Hannah M. Kirton, Moza M. Al‐Owais, Chris Peers, Derek S. Steele · 2018

Modulation of KCNQ Channels by Intracellular Zinc Open

Haixia Gao, Aurélien Boillat, Dongyang Huang, Ce Liang, Chris Peers , et al. · 2018

Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K Open

Lan Cheng, Moza M. Al‐Owais, Manuel Covarrubias, Walter J. Koch, David R. Manning , et al. · 2018

SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric Gi proteins in many cell types, including cardiomyocytes. In this study, we report that activation of SMO with SHH (Sonic Hedgehog) or a small ago…

Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5 Open

Moza M. Al‐Owais, Nishani T. Hettiarachchi, John P. Boyle, Jason L. Scragg, Jacobo Elíes , et al. · 2017

TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p Open

Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout , et al. · 2017

A key role for peroxynitrite‐mediated inhibition of cardiac ERG (Kv11.1) K + channels in carbon monoxide–induced proarrhythmic early afterdepolarizations Open

Moza M. Al‐Owais, Nishani T. Hettiarachchi, Hannah M. Kirton, M Hardy, John P. Boyle , et al. · 2017

Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the late Na + current. The purpose of the present study was to examine the basis for…

Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate Open

Haixia Gao, Aurélien Boillat, Dongyang Huang, Ce Liang, Chris Peers , et al. · 2017

Significance M-type (Kv7, KCNQ) potassium channels are powerful regulators of neuronal and muscular excitability and are validated drug targets for the treatment of excitability disorders. The plasma membrane phosphoinositide phosphatidyli…

Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes Open

Nishani T. Hettiarachchi, John P. Boyle, Mark Dallas, Moza M. Al‐Owais, Jason L. Scragg , et al. · 2017

Epac2-Rap1 Signaling Influences Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias Open

Zhaokang Yang, Hannah M. Kirton, Moza M. Al‐Owais, Chris Peers, Derek S. Steele · 2017

Astrocytic transporters in Alzheimer's disease Open

Chris Ugbode, Yuhan Hu, Benjamin J. Whalley, Chris Peers, Marcus Rattray , et al. · 2017

Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, …

Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. Open

Thomas J. Cahill, Vincenzo Leo, Matthew Kelly, Alexander Stockenhuber, Nolan W. Kennedy , et al. · 2016

Chunyan Liao's and Grazia M. Cereghetti's names were misspelled. The names have been corrected as shown above.

Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias Open

Zhaokang Yang, Hannah M. Kirton, Moza M. Al‐Owais, Jérôme Thireau, Sylvain Richard , et al. · 2016

Epac2-Rap1 signaling attenuates mitochondrial ROS production and reduces myocardial arrhythmia susceptibility. Antioxid. Redox Signal. 27, 117-132.

Redox-Dependent Modulation of T-Type Ca2+ Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P Open

Dongyang Huang, Sha Huang, Haixia Gao, Yani Liu, Jinlong Qi , et al. · 2016

SP modulates T-type channel activity in nociceptors by a redox-dependent tuning of channel sensitivity to zinc; this novel modulatory pathway contributes to the peripheral anti-nociceptive effect of SP. Antioxid. Redox Signal. 25, 233-251.

Person-Centered, Physical Activity for Patients with Low Back Pain: Piloting Service Delivery Open

Saul Bloxham, Phil Barter, Slafka Scragg, Chris Peers, Ben Jane , et al. · 2016

Low back pain (LBP) is one of the most common and costly conditions in industrialized countries. Exercise therapy has been used to treat LBP, although typically using only one mode of exercise. This paper describes the method and initial f…

Intracellular Zinc and Ascorbate Potentiate KCNQ Currents via Distinct Mechanisms Open

Aurélien Boillat, Haixia Gao, Chris Peers, Nikita Gamper · 2016

Intracellular Zinc Potentiates KCNQ Channels through Modulation of their Sensitivity to PIP2 Open

Haixia Gao, Aurélien Boillat, Chris Peers, Nikita Gamper · 2016

Regulation of the T‐type Ca2+channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2S in nociception Open

Jacobo Elíes, Jason L. Scragg, John P. Boyle, Nikita Gamper, Chris Peers · 2016

Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide. Indeed, many of the biological actions of these gas…

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