Chris Pook
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View article: Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up
Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up Open
Faecal microbiota transplantation (FMT) has been explored as a potential treatment for obesity, but its long-term effects on metabolic health remain unclear. Here, we report 4-year follow-up findings from a double-blind, randomised, placeb…
View article: Complete genome sequence of <i>Escherichia marmotae</i> F12YCO47 isolated from a healthy human fecal sample
Complete genome sequence of <i>Escherichia marmotae</i> F12YCO47 isolated from a healthy human fecal sample Open
Escherichia marmotae has been found in animals and the environment. Here, we isolated it from a healthy human fecal sample. The 4.91 Mb circular genome (GC content = 50.34%) is associated with three plasmids: pF12YCO47-2 (89.9 kb, 50.2% GC…
View article: Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition
Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition Open
Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions. Survivors often suffer lasting neurocognitive consequences that impact academic performance and socioeconomic outcomes. Mechanist…
View article: Anti‐inflammatory effects of kawakawa (<i>Piper excelsum</i>): An integrative mRNA–miRNA approach
Anti‐inflammatory effects of kawakawa (<i>Piper excelsum</i>): An integrative mRNA–miRNA approach Open
Kawakawa ( Piper excelsum ) is an endemic medicinal plant widely consumed by Māori in New Zealand. Presence of diverse biologically active phytochemicals in kawakawa may underpin its putative therapeutic anti‐inflammatory properties. Howev…
View article: Polar metabolomics using trichloroacetic acid extraction and porous graphitic carbon stationary phase
Polar metabolomics using trichloroacetic acid extraction and porous graphitic carbon stationary phase Open
Introduction Accurately identifying and quantifying polar metabolites using untargeted metabolomics has proven challenging in comparison to mid to non-polar metabolites. Hydrophilic interaction chromatography and gas chromatography–mass sp…
View article: Alterations in gut microbiota composition, plasma lipids, and brain activity, suggest inter-connected pathways influencing malnutrition-associated cognitive and neurodevelopmental changes.
Alterations in gut microbiota composition, plasma lipids, and brain activity, suggest inter-connected pathways influencing malnutrition-associated cognitive and neurodevelopmental changes. Open
Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions, with nearly half of child deaths under five linked to malnutrition. Survivors face lasting consequences, including impaired neuro…
View article: Role of Extracellular Vesicles (EVs) in Mediating Antioxidant Response to a Glucoraphanin Rich Meal
Role of Extracellular Vesicles (EVs) in Mediating Antioxidant Response to a Glucoraphanin Rich Meal Open
Aging is associated with increasing oxidative stress and declining antioxidant defences, making the body susceptible to various chronic conditions. Cruciferous vegetables contain glucoraphanin, which is metabolised into sulforaphane (SFN) …
View article: Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis
Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis Open
Purpose Piper excelsum (kawakawa), a vascular plant endemic to Aotearoa, New Zealand, is of cultural and medicinal importance to Māori. Presence of biologically active compounds in kawakawa may underpin its putative beneficial health prope…
View article: Human Metabolism and Excretion of Kawakawa (<i>Piper excelsum</i>) Leaf Chemicals
Human Metabolism and Excretion of Kawakawa (<i>Piper excelsum</i>) Leaf Chemicals Open
Scope Piper excelsum (kawakawa) has a history of therapeutic use by Māori in Aotearoa New Zealand. It is currently widely consumed as a beverage and included as an ingredient in “functional” food product. Leaves contain compounds that are …
View article: Polar metabolomics using trichloroacetic acid extraction and porous graphitic carbon stationary phase.
Polar metabolomics using trichloroacetic acid extraction and porous graphitic carbon stationary phase. Open
Accurately identifying and quantifying polar metabolites using untargeted metabolomics has proven challenging in comparison to mid to non-polar metabolites. Hydrophilic interaction chromatography and gas chromatography-mass spectrometry ar…
View article: 4-Ethylphenol—fluxes, metabolism and excretion of a gut microbiome derived neuromodulator implicated in autism
4-Ethylphenol—fluxes, metabolism and excretion of a gut microbiome derived neuromodulator implicated in autism Open
Gut-microbiome-derived metabolites, such as 4-Ethylphenol [4EP], have been shown to modulate neurological health and function. Although the source of such metabolites is becoming better understood, knowledge gaps remain as to the mechanism…
View article: Exploring the Chemical Space of Kawakawa Leaf (Piper excelsum)
Exploring the Chemical Space of Kawakawa Leaf (Piper excelsum) Open
The chemical profiles of kawakawa (Piper excelsum) leaves were analysed through targeted and non-targeted LC-MS/MS. The phytochemical profile was obtained for both aqueous extracts representative of kawakawa tea and methanolic extracts. Si…
View article: Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children
Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children Open
Fat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights…
View article: Exploring the chemical space of kawakawa leaf (Piper excelsum)
Exploring the chemical space of kawakawa leaf (Piper excelsum) Open
Preprint of our manuscript on the chemical space of kawakawa.
View article: Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population
Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population Open
Background: Piper excelsum (kawakawa) is an endemic shrub of Aotearoa, New Zealand, of cultural and medicinal importance to Māori. Its fruits and leaves are often consumed. These tissues contain several compounds that have been shown to be…
View article: Simultaneous Quantification of Organic Acids in Tamarillo (Solanum betaceum) and Untargeted Chemotyping Using Methyl Chloroformate Derivatisation and GC-MS
Simultaneous Quantification of Organic Acids in Tamarillo (Solanum betaceum) and Untargeted Chemotyping Using Methyl Chloroformate Derivatisation and GC-MS Open
Sixteen organic acids were quantified in peel and pulp of Amber, Laird’s Large and Mulligan cultivars of tamarillo using GC-MS. Fourteen of these compounds had not previously been quantified in tamarillo. An untargeted metabolomics approac…
View article: Volatile Components and Preliminary Antibacterial Activity of Tamarillo (Solanum betaceum Cav.)
Volatile Components and Preliminary Antibacterial Activity of Tamarillo (Solanum betaceum Cav.) Open
Tamarillo is a nutrient-dense fruit with a unique aroma from its volatile compounds (VCs). In this study, we aimed to compare the volatile profiles: (i) of fresh and freeze-dried tamarillo; (ii) detected using Thermal Desorption–Gas Chroma…
View article: Absolute quantification of eleven A, D, E and K vitamers in human plasma using automated extraction and UHPLC-Orbitrap MS
Absolute quantification of eleven A, D, E and K vitamers in human plasma using automated extraction and UHPLC-Orbitrap MS Open
Fat-Soluble Vitamers [FSV] deficiencies and hypervitaminosis are associated with lifestyle diseases such as cardiovascular disease, diabetes, and cancer. Quantification of FSV and their metabolites in plasma has proved to be one of the mos…
View article: Odor-active volatile compounds in preterm breastmilk
Odor-active volatile compounds in preterm breastmilk Open
Background Volatile compounds in breastmilk (BM) likely influence flavor learning and, through the cephalic phase response, metabolism, and digestion. Little is known about the volatile compounds present in preterm BM. We investigated whet…
View article: Cortical Oxygenation Changes during Gastric Tube Feeding in Moderate- and Late-Preterm Babies: A NIRS Study
Cortical Oxygenation Changes during Gastric Tube Feeding in Moderate- and Late-Preterm Babies: A NIRS Study Open
Smell and taste of food can trigger physiological responses facilitating digestion and metabolism of nutrients. Controlled experimental studies in preterm babies have demonstrated that smell activates the orbitofrontal cortex (OFC) but non…
View article: Olfactory Cues in Infant Feeds: Volatile Profiles of Different Milks Fed to Preterm Infants
Olfactory Cues in Infant Feeds: Volatile Profiles of Different Milks Fed to Preterm Infants Open
Background: Smell is determined by odor-active volatile compounds that bind to specific olfactory receptors, allowing us to discriminate different smells. Olfactory stimulation may assist with digestion and metabolism of feeds in the neona…
View article: LC-MS/MS quantification of fat soluble vitamers – A systematic review
LC-MS/MS quantification of fat soluble vitamers – A systematic review Open
Fat soluble vitamers (FSV) are several biochemically diverse micronutrients essential for healthy development, growth, metabolism, and cell regulation. We cannot synthesize FSV completely or at the required concentrations. Deficiency or ex…
View article: Quantification of Carotenoids, α-Tocopherol, and Ascorbic Acid in Amber, Mulligan, and Laird’s Large Cultivars of New Zealand Tamarillos (Solanum betaceum Cav.)
Quantification of Carotenoids, α-Tocopherol, and Ascorbic Acid in Amber, Mulligan, and Laird’s Large Cultivars of New Zealand Tamarillos (Solanum betaceum Cav.) Open
Amber (yellow), Laird’s Large (red) and Mulligan (purple–red) cultivars of New Zealand tamarillo fruit were separated into pulp (endo- and mesocarp) and peel (exocarp), and analyzed by liquid chromatography-mass spectrometry/mass spectrome…
View article: Phenolic and Anthocyanin Compounds and Antioxidant Activity of Tamarillo (Solanum betaceum Cav.)
Phenolic and Anthocyanin Compounds and Antioxidant Activity of Tamarillo (Solanum betaceum Cav.) Open
This study examined phenolics and anthocyanins present in Amber, Laird’s Large and Mulligan cultivars of tamarillo that were cultivated in Whangarei, Northland of New Zealand. Samples were further separated by their tissue types, peel and …
View article: Water relations determine short time leaf growth patterns in the mangrove <scp><i>Avicennia marina</i></scp> (<scp>Forssk</scp>.) <scp>Vierh</scp>.
Water relations determine short time leaf growth patterns in the mangrove <span><i>Avicennia marina</i></span> (<span>Forssk</span>.) <span>Vierh</span>. Open
High‐resolution leaf growth is rarely studied despite its importance as a metric for plant performance and resource use efficiency. This is in part due to methodological challenges. Here, we present a method for in situ leaf growth measure…
View article: Neonicotinoid insecticide residues in New Zealand maize paddock soil
Neonicotinoid insecticide residues in New Zealand maize paddock soil Open
Neonicotinoid are the most commonly used class of insecticides. Between 2005 and 2010 neonicotinoid use in the USA and UK more than doubled. Anecdotal evidence suggests similar trends exist in New Zealand, where neonicotinoid seed coatings…
View article: Neonicotinoid insecticide residues in New Zealand maize paddock soil
Neonicotinoid insecticide residues in New Zealand maize paddock soil Open
Neonicotinoid are the most commonly used class of insecticides. Between 2005 and 2010 neonicotinoid use in the USA and UK more than doubled. Anecdotal evidence suggests similar trends exist in New Zealand, where neonicotinoid seed coatings…