Christopher M. Rose
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View article: Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera
Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera Open
The endoplasmic-reticulum (ER) transmembrane protein IRE1 mitigates ER stress through kinase-endoribonuclease and scaffolding activities. Cancer cells often co-opt IRE1 to facilitate growth. An IRE1-RNase inhibitor has entered clinical tri…
View article: A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917
A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917 Open
Bacteria that colonize the human gut must withstand a variety of stressors, including detergent-like compounds known as bile acids. Here, we investigated how bile acids found in the human cecum and colon impact the behavior of the probioti…
View article: Dissecting the antigen presentation pathway by mass spectrometry to elucidate HLA neoantigen presentation 9084
Dissecting the antigen presentation pathway by mass spectrometry to elucidate HLA neoantigen presentation 9084 Open
Description The HLA-peptide (HLAp) complex facilitates adaptive immune responses by presenting the intra- and extracellular protein content to T cells. Frequent somatic mutations presented as HLAp (shared neoantigens) are attractive target…
View article: Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review
Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review Open
Background and aim The HR-positive/HER2-negative (HR+/HER2-) advanced/metastatic breast cancer (a/mBC) treatment landscape has advanced with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i), yet outcome disparities persist, particularly am…
View article: Architecture and Function of Holocentric CENP-A-Independent Kinetochores
Architecture and Function of Holocentric CENP-A-Independent Kinetochores Open
Kinetochores are essential macromolecular complexes that anchor chromosomes to the mitotic spindle to ensure faithful cell division 1 . Despite their critical role, the structural organization of kinetochores assembled on centromeres with …
QT STAR: concomitant QTc-prolonging medication use among patients with HR+/HER2− metastatic breast cancer receiving a CDK4/6 inhibitor in first line Open
QTc-prolonging medication use was common in patients with HR+/HER2- mBC receiving 1L CDK4/6i plus AI treatment, highlighting the importance of reviewing concomitant medications to inform CDK4/6i selection and patient monitoring while on tr…
View article: Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion
Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion Open
Cancer dissemination by perineural invasion (PNI) is associated with poor outcomes in epithelial malignancies, yet the cellular interactions critical to this process are not fully defined. Single-cell transcriptomic analysis of cutaneous s…
View article: COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway
COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway Open
Aberrant activation of the mitogen-activated protein kinase (MAPK) cascade promotes oncogenic transcriptomes. Despite efforts to inhibit oncogenic kinases, such as BRAFV600E, tumor responses in patients can be heterogeneous and limited by …
View article: A microbiota-derived bile acid modulates biofilm formation by the probiotic strain <i>Escherichia coli</i> Nissle 1917
A microbiota-derived bile acid modulates biofilm formation by the probiotic strain <i>Escherichia coli</i> Nissle 1917 Open
Bacteria that colonize the human gut must withstand a variety of stressors, including detergent-like compounds known as bile acids. Here, we investigated how bile acids found in the human cecum and colon impact the behavior of the probioti…
View article: Nova: A library for rapid development of mass spectrometry software applications
Nova: A library for rapid development of mass spectrometry software applications Open
Nova is a software library for the reading, writing, and management of mass spectrometry data natively in the C# language. It complements similar software libraries ubiquitously used in application development for C++, Python, and Java. Fe…
View article: Offset Mass Carrier Proteome Improves Quantification of Multiplexed Single Cell Proteomics
Offset Mass Carrier Proteome Improves Quantification of Multiplexed Single Cell Proteomics Open
Multiplexed single cell proteomics by mass spectrometry (scpMS) approaches currently offer the highest throughput as measured by cells analyzed per day. These methods employ isobaric labels and typically a carrier proteome, a sample added …
View article: Cell-Type-Specific Surfaceome Profiling of 100-500 Isolated Cells using a Droplet-Based Magnetic Affinity Purification System
Cell-Type-Specific Surfaceome Profiling of 100-500 Isolated Cells using a Droplet-Based Magnetic Affinity Purification System Open
Cell surface proteins (CSPs) represent an important source of biomarkers and therapeutic targets. However, due to the inherent sensitivity limitations of existing technologies, tissue and cell-type-specific surfaceomes remain poorly charac…
View article: Near-instant prediction of short-term transfer functions for closed-loop boreholes in heterogeneous aquifers influenced by groundwater flow using wavelet decomposition and neural networks
Near-instant prediction of short-term transfer functions for closed-loop boreholes in heterogeneous aquifers influenced by groundwater flow using wavelet decomposition and neural networks Open
Accurate simulation of the heat pump inlet fluid temperature is critical to the design of an optimal, high performance ground source heat pump system. The closed-loop ground heat exchanger must be able to meet the heating and cooling deman…
View article: Real-world effectiveness of CDK4/6i in first-line treatment of HR+/HER2− advanced/metastatic breast cancer: updated systematic review
Real-world effectiveness of CDK4/6i in first-line treatment of HR+/HER2− advanced/metastatic breast cancer: updated systematic review Open
Aim Since 2021, additional real-world evidence (RWE) has emerged on the effectiveness of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) as first-line treatment of HR-positive/HER2-negative (HR+/HER2−) advanced/metastatic breast cancer (A…
View article: Impairment of DET1 causes neurological defects and lethality in mice and humans
Impairment of DET1 causes neurological defects and lethality in mice and humans Open
COP1 and DET1 are components of an E3 ubiquitin ligase that is conserved from plants to humans. Mammalian COP1 binds to DET1 and is a substrate adaptor for the CUL4A-DDB1-RBX1 RING E3 ligase. Transcription factor substrates, including c-Ju…
View article: Relative quantification of proteins and post-translational modifications in proteomic experiments with shared peptides: a weight-based approach
Relative quantification of proteins and post-translational modifications in proteomic experiments with shared peptides: a weight-based approach Open
Motivation Bottom-up mass spectrometry-based proteomics studies changes in protein abundance and structure across conditions. Since the currency of these experiments are peptides, i.e. subsets of protein sequences that carry the quantitati…
View article: Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation Open
The Hippo pathway is among the most frequently altered key signaling pathways in cancer. TEAD1-4 are essential transcription factors and key downstream effectors in the Hippo pathway in human cells. Here, we identified RNF146 as a ubiquiti…
Reactive oxygen species control protein degradation at the mitochondrial import gate Open
While reactive oxygen species (ROS) have long been known to drive aging and neurodegeneration, their persistent depletion below basal levels also disrupts organismal function. Cells counteract loss of basal ROS via the reductive stress res…
View article: An RNA damage response network mediates the lethality of 5-FU in colorectal cancer
An RNA damage response network mediates the lethality of 5-FU in colorectal cancer Open
5-fluorouracil (5-FU), a major anti-cancer therapeutic, is believed to function primarily by inhibiting thymidylate synthase, depleting deoxythymidine triphosphate (dTTP), and causing DNA damage. Here, we show that clinical combinations of…
View article: Supplementary Data from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma
Supplementary Data from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma Open
supplementary figures & legends
View article: Supplementary Data from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma
Supplementary Data from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma Open
supplementary figures & legends
View article: Supplementary Data Table 2 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma
Supplementary Data Table 2 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma Open
Supplementary table 2
View article: Supplementary Data Table1 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma
Supplementary Data Table1 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma Open
Supplementary Table 1
View article: Supplementary Data Table1 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma
Supplementary Data Table1 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma Open
Supplementary Table 1
View article: Supplementary Data Table 2 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma
Supplementary Data Table 2 from Driver mutations dictate the immunological landscape and response to checkpoint immunotherapy of glioblastoma Open
Supplementary table 2