Chris T. Middleton
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View article: Pan-cancer Analysis of Homologous Recombination Deficiency in Cell Lines
Pan-cancer Analysis of Homologous Recombination Deficiency in Cell Lines Open
Homologous Recombination Deficiency (HRD) drives genomic instability in multiple cancer types and renders tumors vulnerable to certain DNA damaging agents such as PARP inhibitors. Thus, HRD is emerging as an attractive biomarker in oncolog…
View article: Breaking Barriers in Ultrafast Spectroscopy and Imaging Using 100 kHz Amplified Yb-Laser Systems
Breaking Barriers in Ultrafast Spectroscopy and Imaging Using 100 kHz Amplified Yb-Laser Systems Open
ConspectusUltrafast spectroscopy and imaging have become tools utilized by a broad range of scientists involved in materials, energy, biological, and chemical sciences. Commercialization of ultrafast spectrometers including transient absor…
View article: Breaking Barriers in Ultrafast Spectroscopy and Imaging Using 100 kHz Amplified Yb-Laser Systems
Breaking Barriers in Ultrafast Spectroscopy and Imaging Using 100 kHz Amplified Yb-Laser Systems Open
Ultrafast spectroscopy and imaging have become tools utilized by a broad range of scientists involved in materials, energy, biological, and chemical sciences. Commercialization of ultrafast spectrometers including transient absorption spec…
View article: Shot-to-shot 2D IR spectroscopy at 100 kHz using a Yb laser and custom-designed electronics
Shot-to-shot 2D IR spectroscopy at 100 kHz using a Yb laser and custom-designed electronics Open
The majority of 2D IR spectrometers operate at 1-10 kHz using Ti:Sapphire laser technology. We report a 2D IR spectrometer designed around Yb:KGW laser technology that operates shot-to-shot at 100 kHz. It includes a home-built OPA, a mid-I…
View article: Supplementary document for Shot-to-shot 2D IR spectroscopy at 100 kHz using a Yb laser and custom designed electronics - 4814481.pdf
Supplementary document for Shot-to-shot 2D IR spectroscopy at 100 kHz using a Yb laser and custom designed electronics - 4814481.pdf Open
Calculation of correlation matrix for referencing; Implementation of spectral baseline removal; MCT array and detector electronics configuration; OpAmp frequency response; Spectra of hIAPP; Laser and detector noise spectra
View article: Award Winners and Abstracts of the 30th Anniversary Symposium of The Protein Society, Baltimore, MD, July 16–19, 2016
Award Winners and Abstracts of the 30th Anniversary Symposium of The Protein Society, Baltimore, MD, July 16–19, 2016 Open
the combinatorial complexity of simultaneously occurring histone modifications, identifying thousands of uniquely modified histone H3 forms, the significance of which is the focus of current research interest (e.g.combinatorial Histone Cod…
View article: Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics Open
Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produce…
View article: Author response: Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Author response: Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics Open