Chris Van Dijk
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View article: Impaired cardiac mitochondrial bioenergetics contribute to loss of cardiac function, in a porcine multiple risk factor model
Impaired cardiac mitochondrial bioenergetics contribute to loss of cardiac function, in a porcine multiple risk factor model Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dutch CardioVascular Alliance (an initiative with support of the Dutch Heart Foundation) Grant 2020B008 RECONNEXT, and the Ge…
View article: Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem-Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel
Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem-Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel Open
Introduction: Vascular smooth muscle cells (VSMCs) play a pivotal role in vascular homeostasis, with dysregulation leading to vascular complications. Human-induced pluripotent stem-cell (hiPSC)-derived VSMCs offer prospects for personalize…
View article: Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethral stricture disease
Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethral stricture disease Open
The urogenital tract is a target for many congenital and acquired diseases, both benign and oncogenic. In males, the urethra that transports urine and semen can be obstructed by a fibrotic disease called urethral stricture disease (USD). I…
View article: Mapping individual cardiac cell types and their contribution in the development of heart failure in a multiple comorbidity porcine model
Mapping individual cardiac cell types and their contribution in the development of heart failure in a multiple comorbidity porcine model Open
Background Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired left ventricular (LV) relaxation and filling due to increased myocardial stiffness and hypertrophy. The development of HFpEF is associated with …
View article: Impaired cardiac BCAA catabolism associated with impaired myocardial efficiency during exercise in a porcine model with multiple risk factors
Impaired cardiac BCAA catabolism associated with impaired myocardial efficiency during exercise in a porcine model with multiple risk factors Open
Background Diabetes mellitus (DM), chronic kidney disease (CKD) and consumption of a high-fat diet (HFD), are well known risk factors for diastolic heart failure. We recently developed a multiple comorbidity swine model (MCS), with DM (str…
View article: The Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel
The Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel Open
Introduction Vascular smooth muscle cells (VSMCs) play a pivotal role in vascular homeostasis, with dysregulation leading to vascular complications. Human induced pluripotent stem cell (hiPSC)-derived VSMCs offer prospects for personalized…
View article: A complex three-dimensional microfluidic model that mimics the early stage events in the human atherosclerotic artery
A complex three-dimensional microfluidic model that mimics the early stage events in the human atherosclerotic artery Open
Background Atherosclerosis is a complex inflammatory vascular disease characterized by lipid and immune cells accumulation in the vessel wall, leading to lumen narrowing. Although several 3D in vitro microfluidic systems were previously de…
View article: 3D Human iPSC Blood Vessel Organoids as a Source of Flow‐Adaptive Vascular Cells for Creating a Human‐Relevant 3D‐Scaffold Based Macrovessel Model
3D Human iPSC Blood Vessel Organoids as a Source of Flow‐Adaptive Vascular Cells for Creating a Human‐Relevant 3D‐Scaffold Based Macrovessel Model Open
3D‐scaffold based in vitro human tissue models accelerate disease studies and screening of pharmaceutics while improving the clinical translation of findings. Here is reported the use of human induced pluripotent stem cell (hiPSC)‐derived …
View article: End-to-end design framework for compressed on-chip pixel-wise spectro-polarimeters
End-to-end design framework for compressed on-chip pixel-wise spectro-polarimeters Open
Modern detector manufacturing allows spectral and polarimetric filters to be directly integrated on top of separate detector pixels. This enables the creation of CubeSat-sized spectro-polarimetric instruments that are not much larger than …
View article: Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells
Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells Open
Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the granules of cytotoxic c…
View article: Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis Open
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are pivotal regulators of extracellular matrix (ECM) composition and could, due to their dynamic activity, function as prognostic tools for fibrosis and c…
View article: Extracellular Matrix Analysis of Human Renal Arteries in Both Quiescent and Active Vascular State
Extracellular Matrix Analysis of Human Renal Arteries in Both Quiescent and Active Vascular State Open
In vascular tissue engineering strategies, the addition of vascular-specific extracellular matrix (ECM) components may better mimic the in vivo microenvironment and potentially enhance cell–matrix interactions and subsequent tissue growth.…
View article: Additional file 9 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Additional file 9 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts Open
Additional file 9. Supplementary Table 3. a Genes in the vicinity of hyperacetylated regions using a ± 5 kb window. b Genes in the vicinity of hypoacetylated regions using a ± 5 kb window.
View article: Additional file 14 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Additional file 14 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts Open
Additional file 14. Supplementary Table 8. The chromatin acetylation changes and the mRNA expression changes of key regulators and targets in the Hippo pathway.
View article: Additional file 11 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Additional file 11 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts Open
Additional file 11. Supplementary Table 5. Identified transcription binding motifs from differentially acetylated regions.
View article: Additional file 10 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Additional file 10 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts Open
Additional file 10. Supplementary Table 4. Differentially expressed genes between patients and controls.
View article: Additional file 7 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Additional file 7 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts Open
Additional file 7 Supplementary Table 1. Regions with different H3K27ac occupancy in patients compared with the control group (adjusted p value < 0.05).
View article: Additional file 8 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Additional file 8 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts Open
Additional file 8. Supplementary Table 2. a Identified active tandem regulated chromatin domains (TRCDs) in the short range (5Kb–100Kb) in patients when compared with controls. b Identified active TRCDs in the long range (100Kb–1 Mb) in pa…
View article: A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix
A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix Open
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
View article: Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis
Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis Open
Our data demonstrate a functional relevance for Cgnl1 as a defining factor in new vessel formation both in vitro and in vivo.
View article: CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions
CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions Open
Objective— Decrease in VE-cadherin adherens junctions reduces vascular stability, whereas disruption of adherens junctions is a requirement for neovessel sprouting during angiogenesis. Endocytosis plays a key role in regulating junctional …
View article: Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic Syndrome
Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic Syndrome Open
Background— The combination of cardiac and renal disease driven by metabolic risk factors, referred to as cardiorenal metabolic syndrome (CRMS), is increasingly recognized as a critical pathological entity. The contribution of (micro)vascu…
View article: <i>THSD1</i>preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE<sup>−/−</sup>mice
<i>THSD1</i>preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE<sup>−/−</sup>mice Open
THSD1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions.