Chris Vervaet
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View article: Fading microscopic codes to protect pharmaceuticals from counterfeiting
Fading microscopic codes to protect pharmaceuticals from counterfeiting Open
View article: Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation
Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation Open
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol…
View article: Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters
Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters Open
Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with…
View article: Preclinical Activity of Two Paclitaxel Nanoparticle Formulations After Intraperitoneal Administration in Ovarian Cancer Murine Xenografts
Preclinical Activity of Two Paclitaxel Nanoparticle Formulations After Intraperitoneal Administration in Ovarian Cancer Murine Xenografts Open
Intraperitoneal administration of both nab-PTX and mic-PTX results in a significant anticancer efficacy and survival benefit in a mouse OC xenograft model.
View article: Batch vs. continuous direct compression – a comparison of material processability and final tablet quality
Batch vs. continuous direct compression – a comparison of material processability and final tablet quality Open
View article: CO<sub>2</sub>-Driven Nebulization of pH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis
CO<sub>2</sub>-Driven Nebulization of pH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis Open
Because peritoneal metastasis (PM) from ovarian cancer is characterized by non-specific symptoms, it is often diagnosed at advanced stages. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) can be considered a promising drug deliver…
View article: Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential
Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential Open
View article: Development of Diclofenac Sodium 3D Printed Cylindrical and Tubular-Shaped Tablets through Hot Melt Extrusion and Fused Deposition Modelling Techniques
Development of Diclofenac Sodium 3D Printed Cylindrical and Tubular-Shaped Tablets through Hot Melt Extrusion and Fused Deposition Modelling Techniques Open
The present study aimed to develop 3D printed dosage forms, using custom-made filaments loaded with diclofenac sodium (DS). The printed tablets were developed by implementing a quality by design (QbD) approach. Filaments with adequate FDM …
View article: WITHDRAWN: The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating
WITHDRAWN: The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating Open
The effect of particle size on the sublimation behavior of butylhydroxytoluene (BHT) was investigated when BHT was included as antioxidant in tablets. Sublimation of pure BHT was found to be independent of its particle size, with pore form…
View article: Light‐Based 3D Printing of Gelatin‐Based Biomaterial Inks to Create a Physiologically Relevant In Vitro Fish Intestinal Model
Light‐Based 3D Printing of Gelatin‐Based Biomaterial Inks to Create a Physiologically Relevant In Vitro Fish Intestinal Model Open
To provide prominent accessibility of fishmeal to the European population, the currently available, time‐ and cost‐extensive feeding trials, which evaluate fish feed, should be replaced. The current paper reports on the development of a no…
View article: Impact of material properties and process parameters on tablet quality in a continuous direct compression line
Impact of material properties and process parameters on tablet quality in a continuous direct compression line Open
View article: Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam
Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam Open
Diazepam (DZP) is a long-acting benzodiazepine to treat anxiety or acute alcohol withdrawal. Although this class of drugs should be taken for a short period of time, many patients take them for longer than recommended, which has been linke…
View article: Development of Flow-Through Cell Dissolution Method for In Situ Visualization of Dissolution Processes in Solid Dosage Forms Using X-ray μCT
Development of Flow-Through Cell Dissolution Method for In Situ Visualization of Dissolution Processes in Solid Dosage Forms Using X-ray μCT Open
Visualization of the dynamic behavior of pharmaceutical dosage forms during the dissolution process offers a better understanding of the drug release mechanism, enabling the design of customized dosage forms. In this study, an X-ray tomogr…
View article: Formation of delta-mannitol by co-spray drying: enhancing the tabletability of paracetamol/mannitol formulations
Formation of delta-mannitol by co-spray drying: enhancing the tabletability of paracetamol/mannitol formulations Open
View article: Multi-frame DVC for temporal image sequences
Multi-frame DVC for temporal image sequences Open
Digital volume correlation (DVC) is a 3D image-based technique for displacement and strain computation. Traditionally, both (digital image correlation) DIC and DVC are methods based on two individual time frames; the estimation of the disp…
View article: Stable amorphous solid dispersion of flubendazole with high loading via electrospinning
Stable amorphous solid dispersion of flubendazole with high loading via electrospinning Open
View article: Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading
Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading Open
View article: Impact of alternative lubricants on process and tablet quality for direct compression
Impact of alternative lubricants on process and tablet quality for direct compression Open
View article: 3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice
3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice Open
Bacterial infections are a serious healthcare complication in orthopedic and trauma surgery worldwide. Compared to systemic, local antibiotic prophylaxis has been shown to provide a higher antibiotic dose and bioavailability at the bone si…
View article: The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling
The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling Open
View article: Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press
Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press Open
View article: In-depth analysis of the long-term processability of materials during continuous feeding
In-depth analysis of the long-term processability of materials during continuous feeding Open
View article: The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation
The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation Open
View article: Formation of Delta-Mannitol by Co-Spray Drying: Enhancing the Tabletability of Paracetamol/Mannitol Formulations
Formation of Delta-Mannitol by Co-Spray Drying: Enhancing the Tabletability of Paracetamol/Mannitol Formulations Open
View article: Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation Open
View article: Impact of blend properties and process variables on the blending performance
Impact of blend properties and process variables on the blending performance Open
View article: A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying
A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying Open
The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the im…
View article: Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State
Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State Open
Spin freeze-drying, as a part of a continuous freeze-drying technology, is associated with a much higher drying rate and a higher level of process control in comparison with batch freeze-drying. However, the impact of the spin freezing rat…
View article: Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying
Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying Open
During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a…
View article: Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed Caplets: A Quality-by-Design Approach
Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed Caplets: A Quality-by-Design Approach Open
Extrusion-based 3D-printing is an easy-to-use, cheap manufacturing technique that could be used to produce tailored precision medicines. The technique has an almost unlimited versatility since a multitude of print parameters can easily be …