Christella E. Widjaja
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View article: Therapeutic Blockade of Type 2 Cytokines and PD1 Unleashes Anti-Tumor Immunity Through Coordinated Reprogramming of Innate and Adaptive Immune Surveillance
Therapeutic Blockade of Type 2 Cytokines and PD1 Unleashes Anti-Tumor Immunity Through Coordinated Reprogramming of Innate and Adaptive Immune Surveillance Open
Background Checkpoint inhibitors improve survival in patients with several types of tumors. However, resistance to checkpoint inhibitors creates an opportunity for patients to benefit from novel immunotherapies. The type 2 cytokines IL-4, …
View article: The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression
The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression Open
During an immune response to microbial infection, CD8+ T cells give rise to short-lived effector cells and memory cells that provide sustained protection. Although the transcriptional programs regulating CD8+ T cell differentiation have be…
View article: Ulcerative Colitis Host-Microbiome Response to Hyperbaric Oxygen Therapy
Ulcerative Colitis Host-Microbiome Response to Hyperbaric Oxygen Therapy Open
Objective This study examined the host-microbe changes underpinning treatment response to hyperbaric oxygen therapy (HBOT) in ulcerative colitis. Design Pre- and post-intervention mucosal tissue and fecal samples from two clinical trials, …
View article: The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients
The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients Open
HBOT reduces host neutrophil STAT3 and azurophilic granule activity in UC patients and changes in microbial composition and metabolism in ways that improve colitis activity. Intestinal microbiota, especially strain level variations in A mu…
View article: Early precursors and molecular determinants of tissue-resident memory CD8 <sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing
Early precursors and molecular determinants of tissue-resident memory CD8 <sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing Open
Heterogeneity of small intestine intraepithelial CD8 + T cells suggests functionally distinct subsets of T RM cells and their precursors.
View article: Functional delineation of tissue-resident CD8<sup>+</sup>T cell heterogeneity during infection and cancer
Functional delineation of tissue-resident CD8<sup>+</sup>T cell heterogeneity during infection and cancer Open
Unremitting defense against diverse pathogens and malignancies requires a dynamic and durable immune response. Tissue-resident memory CD8 + T cells (T rm ) afford robust protection against infection and cancer progression through continuou…
View article: Molecular determinants and heterogeneity of tissue-resident memory CD8<sup>+</sup>T lymphocytes revealed by single-cell RNA sequencing
Molecular determinants and heterogeneity of tissue-resident memory CD8<sup>+</sup>T lymphocytes revealed by single-cell RNA sequencing Open
During an immune response to microbial infection, CD8 + T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subs…
View article: Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification Open
During an immune response, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt terminal effector and memory cell fates. Here we show that "pre-effector" and "pre-memor…
View article: OP021 Hyperbaric oxygen therapy is safe and effective for hospitalized ulcerative colitis patients suffering from moderate-severe flares: a multi-center, randomized, double-blind, sham-controlled trial
OP021 Hyperbaric oxygen therapy is safe and effective for hospitalized ulcerative colitis patients suffering from moderate-severe flares: a multi-center, randomized, double-blind, sham-controlled trial Open
Background: A dysregulated tissue hypoxia response is central to ulcerative colitis (UC) pathogenesis. Hyperbaric oxygen therapy (HBOT) markedly increases tissue oxygen delivery and case series suggest a potential therapeutic benefit in UC…
View article: Regulation of CD8+ T Lymphocyte Fate Specification by Proteasome Activity and Cellular Metabolism
Regulation of CD8+ T Lymphocyte Fate Specification by Proteasome Activity and Cellular Metabolism Open
In an immune response, CD8+ T lymphocytes can differentiate into effector cells that acutely clear the infection as well as memory cells that provide lasting immunity against the same pathogen. Previous studies have shown that differentiat…
View article: Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition
Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition Open
The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade. While there is substantial support for th…